Recommended Articles - September 2007

Recommended by: Kouji Kajinami, MD, FACP, FAHA, FJSIM

• Genetic analysis of fluvastatin response and dyslipidemia in renal transplant recipients.
  (Singer JB, et al. J Lipid Res 2007;48:2072-2078.)

Recommended by: Sudesh Agrawal, PhD

• Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development.
  (Agarwal, et al. Circulation. 2007 Jun 12;115(23):2939-47. Epub 2007 May 28.)

Recommended by Santiago Redono, MD, PhD

• Reduced numbers of circulating endothelial progenitor cells in patients with
  coronary artery disease associated with long-term statin treatment.
  Hristov M, et al. Atherosclerosis. 2007 Jun;192(2):413-20.

Recommended by J. David Spence MD, FRCPC, FAHA

• Combining multiple approaches for the secondary
  prevention of vascular events after stroke: a quantitative modeling study.
  (Hackam DG, et al. Stroke 2007; April; epub ahead of print.)
• Intensive management of risk factors for accelerated atherosclerosis: the role of multiple interventions.
  (Spence JD. Curr Neurol Neurosci Rep. 2007; 7:42-8. )

Recommended by Reto Asmis, PhD

• Increased expression of cytosolic and mitochondrial glutathione reductase in macrophages inhibits atherosclerotic lesion development in LDL receptor-deficient mice.
  (Qiao, M et al.Arterioscler.Thromb.Vasc.Biol . 27, 1375-82 (2007).)

Recommended by David Arjona, MD

• IDF Worldwide Definition of the Metabolic Syndrome

Recommended by Maurizio Crestani, PhD

• BetaKlotho is required for metabolic activity of fibroblast growth factor 21.
  (Ogawa Y, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7432-7. Epub 2007 Apr 23.)
• Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.
  (Badman MK, et al. Cell Metab. 2007 Jun 6;5(6):426-437.)
• Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
  (Inagaki T , et al. Cell Metab. 2007 Jun;5(6):415-25.)

Recommended by Eder Quintão, MD

• Effects of increasing doses of atorvastatin on the atherogenic lipid subclasses commonly associated with hypertriglyceridemia.
  (Karalis DG ,et al. Am J Cardiol. 2007 Aug 1;100(3):445-9. Epub 2007 Jun 13.)
• Impact of statin dosing intensity on transaminase and creatine kinase.
  (Dale KM, et al. Am J Med. 2007 Aug;120(8):706-12.)
• Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression.
  (van der Hoogt CC, et al. J Lipid Res. 2007 Aug;48(8):1763-71. Epub 2007 May 24.)
• Ezetimibe interferes with cholesterol trafficking from the plasma membrane to the endoplasmic reticulum in CaCo-2 cells.
  (Field FJ, et al. J Lipid Res. 2007 Aug;48(8):1735-45. Epub 2007 May 1)
• Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI.
  (Nieland TJ , et al. J Lipid Res. 2007 Aug;48(8):1832-45. Epub 2007 May 28.)
• Concomitant reduction of low-density lipoprotein-cholesterol and biomarkers of inflammation with low-dose simvastatin therapy in patients with type 1 diabetes. (Jialal I , et al. J Clin Endocrinol Metab. 2007 Aug;92(8):3136-40. Epub 2007 May 22.)
• Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival.
  (Leeper NJ, et al. Circulation. 2007 Aug 7;116(6):613-8. Epub 2007 Jul 30.)
• Wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux.
  (Weibel GL , et al. 2007 Sep;27(9):2022-9. Epub 2007 Jul 5.)
• Associations between two common polymorphisms in the ABCA1 gene and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 193(2):352-360 (2007).
  (Benton JL , et al. Atherosclerosis. 2007 Aug;193(2):352-60. Epub 2006 Aug 1)
• Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study.
  (Am J Cardiol. 2007 Aug 1;100(3):445-9. Epub 2007 Jun 13. J Clin Endocrinol Metab. 92(8):3068-3075. (2007)
• Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidative stress induced by selenium deficiency and free radicals.
  (Saito Y, et al. FEBS Lett. 2007 Sep 4;581(22):4349-54. Epub 2007 Aug 14)
• Statin treatment in children with familial hypercholesterolemia: the younger, the better.
  (Rodenburg J, et al.Circulation. 2007 Aug 7;116(6):664-8. Epub 2007 Jul 30.)