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in these Commentaries are those of the authors and are not
necessarily those of IAS.
Effects
of
Statins
on
the
Atherogenic
Lipid
Subclasses
Commonly
Associated
With
Hypertriglyceridemia
Author:
D.G.
Karalis
Recent
studies
have
shown
that
elevated
levels
of
serum
triglycerides
(TG)
are
an
independent
risk
factor
for
coronary
heart
disease
(CHD)
[1].
The
atherogenicity
associated
with
high
levels
of
TG
is
thought
to
be
due
to
the
atherogenic
lipoprotein
subclasses
commonly
associated
with
hypertriglyceridemia
[2,3]
Statins
have
been
shown
to
reduce
cardiovascular
events
in
both
individuals
with
or
at
risk
for
CHD
[4-6].
These
benefits
are
thought
to
be
due
to
the
statin’s
effects
in
lowering
low
density
lipoprotein
(LDL)
cholesterol.
However,
statins
have
effects
on
other
lipoproteins
as
well.
This
discussion
will
review
the
effects
of
statins
on
the
lipid
subclasses
commonly
associated
with
hypertriglyceridemia.
> Read
entire
commentary
Does
Impaired
Adipose
Tissue
Lipid
Storage
Contribute
to
Metabolic
Diseases?
Authors:
V.
Saraswathi,
A.H.
Hasty
Obesity
is
a
key
feature
of
metabolic
syndrome,
which
greatly
predisposes
individuals
to
cardiovascular
disease,
type
2
diabetes,
and
numerous
cancers,
and
is
associated
with
markedly
diminished
life
expectancy
[1].
Nevertheless,
not
all
obese
individuals
develop
metabolic
syndrome
or
insulin
resistance.
Published
evidence
suggests
that
about
20%
of
obese
individuals
have
a
normal
metabolic
profile
and
insulin
sensitivity
[2].
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entire
commentary
Atherosclerosis
and
Cognitive
Function
Author:
A.P.
Haley
Atherosclerosis
has
long
been
recognized
in
clinical
lore
as
an
important
factor
in
the
development
of
dementia
later
in
life.
Patients
of
older
generations
were
often
told
that
their
cognitive
difficulties
were
due
to “hardening
of
the
arteries.” Consistent
with
clinical
wisdom,
large
epidemiological
studies
have
shown
a
significant
relationship
between
surrogate
markers
of
peripheral
atherosclerosis
and
risk
for
dementia
[1].
> Read
entire
commentary
An
Intriguing
Genetic
Association
between
a
Tumor
Suppressor
Locus,
Coronary
Artery
Disease
and
Diabetes
Author:
M.
Farrall
Cases
of
coronary
artery
disease
(CAD)
often
cluster
in
families
which,
backed
up
by
concordance
studies
of
monozygous
and
dizygous
twins,
supports
the
hypothesis
that
CAD
is
a
multifactorial
condition
with
an
important
heritable
component.
Researchers
have
subsequently
expended
much
effort
in
attempts
to
map
specific
variants
that
influence
susceptibility
to
CAD,
mostly
through
the
application
of
the “candidate
gene” paradigm.
Recent
advances
in
genotyping
technology
that
facilitate
the
study
of
hundreds
of
thousands
of
genetic
markers
allow
geneticists
to
greatly
expand
the
scope
of
their
searches
for
susceptibility
genes.
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entire
commentary
Apolipoprotien(a)
Isoforms
and
Lipoprotein(a)
as
Risk
Factors
for
Atherosclerosis
Authors:
K.
Tosheska, D.
Labudovic, S.
Alabakovska, M.
Spiroski, B.
Todorova
A
detailed
study
of
specific
lipoprotein
parameters
is
necessary
in
individuals
at
high
risk
of
coronary
heart
disease
(CHD).
During
the
last
two
decades,
attention
has
been
focused
on
identification
of
new
risk
factors
(such
as
genetic
risk
factors)
in
these
individuals.
One
potential
risk
factor
that
has
been
extensively
studied
is
lipoprotein(a)
[Lp(a)].
It
is
well
documented,
that
Lp(a)
accumulates
in
the
arterial
wall
at
the
sites
of
atherosclerotic
lesions
[1].
> Read
entire
commentary
