up-to-date with a click!
Update September, 2018
 
Curated by Peter Lansberg,
a Dutch lipidologist and educator, and
reviewed by prof. Philip Barter, Past President of the
International Atherosclerosis Society.

The IAS Statin Newsletter will keep you up-to-date with all recent statin publications, using a curated approach to select relevant articles.

Statin publications September 2018

Add on treatments

  1. Mickiewicz A, Borowiec-Wolna J, Bachorski W et al. Long-term lipoprotein apheresis in the treatment of severe familial hypercholesterolemia refractory to high intensity statin therapy: Three year experience at a lipoprotein apheresis centre. Cardiology journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30234904
  2. Mintzer S, Trinka E, Kraemer G et al. Impact of carbamazepine, lamotrigine, and levetiracetam on vascular risk markers and lipid-lowering agents in the elderly. Epilepsia 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30178473
  3. Cicero AFG, Fogacci F, Bove M et al. Optimizing Lipid Pattern by Adding a Combined Nutraceutical or Pravastatin to Fenofibrate Treatment in Hypertriglyceridemic Subjects: Single Site, Randomized, Open-Label, Post-Market Clinical Investigation. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30229462
  4. Leite GAA, de Barros JWF, Martins ADC, Jr. et al. Ascorbic acid supplementation ameliorates testicular hormonal signaling, sperm production and oxidative stress in male rats exposed to rosuvastatin during pre-puberty. Journal of applied toxicology : JAT 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30240002
  5. Roopmani P, Krishnan UM. Harnessing the pleiotropic effects of atorvastatin-fenofibrate combination for cardiovascular stents. Materials science & engineering. C, Materials for biological applications 2018; 92:875-891. http://www.ncbi.nlm.nih.gov/pubmed/?term=30184817
  6. Sun B, Rui R, Pan H et al. Effect of Combined Use of Astragaloside IV (AsIV) and Atorvastatin (AV) on Expression of PPAR-gamma and Inflammation-Associated Cytokines in Atherosclerosis Rats. Medical science monitor : international medical journal of experimental and clinical research 2018; 24:6229-6236. http://www.ncbi.nlm.nih.gov/pubmed/?term=30190450
  7. Turk Veselic M, Erzen B, Hanzel J et al. Improving Arterial Wall Characteristics in Patients After Myocardial Infarction with a Very Low Dose of Fluvastatin and Valsartan: A Proof-of-Concept Study. Medical science monitor : international medical journal of experimental and clinical research 2018; 24:6892-6899. http://www.ncbi.nlm.nih.gov/pubmed/?term=30266894
  8. Song L, Zou G, Wang X. Effect of doxycycline and atorvastatin on improving exercise tolerance in patients with angina pectoris. Pak J Pharm Sci 2018; 31:1731-1735. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203771
  9. Lee J, Lee S. Comparative Effectiveness of Combination Therapy with Statins and Angiotensin-Converting Enzyme Inhibitors versus Angiotensin II Receptor Blockers in Patients with Coronary Heart Disease: A Nationwide Population-Based Cohort Study in Korea. Pharmacotherapy 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30225928 
 Adherence
  1. Range JT, LaFontaine PR, Ryder PT, Polston M. Factors Associated With Adherence to Statin Medications of Patients Enrolled in a Self-insured University Health Plan. Clinical therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30231972

Atherosclerosis & Imaging

  1. Alkhalil M, Biasiolli L, Akbar N et al. T2 mapping MRI technique quantifies carotid plaque lipid, and its depletion after statin initiation, following acute myocardial infarction. Atherosclerosis 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30227984
  2. Osawa K, Trejo MEP, Nakanishi R et al. Coronary artery calcium and carotid artery intima-media thickness for the prediction of stroke and benefit from statins. Eur J Prev Cardiol 2018:2047487318798058. http://www.ncbi.nlm.nih.gov/pubmed/?term=30183342
  3. Sakata K, Gamou T, Tada H et al. Low Baseline High-Sensitive C-Reactive Protein is Associated with Coronary Atherosclerosis Regression: Insights from the MILLION Study. J Atheroscler Thromb 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30249940
  4. Roopmani P, Krishnan UM. Harnessing the pleiotropic effects of atorvastatin-fenofibrate combination for cardiovascular stents. Materials science & engineering. C, Materials for biological applications 2018; 92:875-891. http://www.ncbi.nlm.nih.gov/pubmed/?term=30184817
  5. Sun B, Rui R, Pan H et al. Effect of Combined Use of Astragaloside IV (AsIV) and Atorvastatin (AV) on Expression of PPAR-gamma and Inflammation-Associated Cytokines in Atherosclerosis Rats. Medical science monitor : international medical journal of experimental and clinical research 2018; 24:6229-6236. http://www.ncbi.nlm.nih.gov/pubmed/?term=30190450
  6. Lee D, Joo HJ, Jung HW, Lim DS. Investigating potential mediator between statin and coronary artery calcification. PLoS One 2018; 13:e0203702. http://www.ncbi.nlm.nih.gov/pubmed/?term=30226851
  7. Tahta A, Izgi N, Bagci-Onder T et al. Assessment of the MRI and Behavioral Test Results in a Focal Cerebral Ischemia-Reperfusion Model in the Rat after Separate and Combined Use of Mouse-Derived Neural Progenitor Cells, Human-Derived Neural Progenitor Cells and Atorvastatin. Turkish neurosurgery 2018; 28:571-581. http://www.ncbi.nlm.nih.gov/pubmed/?term=30192361

Atorvastatin/Rosuvastatin

  1. Choi JY, Choi CU, Hwang SY et al. Effect of Pitavastatin Compared with Atorvastatin and Rosuvastatin on New-Onset Diabetes Mellitus in Patients With Acute Myocardial Infarction. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30217375
  2. Munoz-Hernandez L, Ortiz-Bautista RJ, Brito-Cordova G et al. Cholesterol efflux capacity of large, small and total HDL particles is unaltered by atorvastatin in patients with type 2 diabetes. Atherosclerosis 2018; 277:72-79. http://www.ncbi.nlm.nih.gov/pubmed/?term=30176567
  3. Shahbaz A, Mahendhar R, Fransawy Alkomos M et al. Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin. Cureus 2018; 10:e2965. http://www.ncbi.nlm.nih.gov/pubmed/?term=30210953
  4. Krysiak R, Drosdzol-Cop AB, Skrzypulec-Plinta V, Okopien B. The effect of atorvastatin on sexual function and depressive symptoms in young women with elevated cholesterol levels: a pilot study. Endokrynol Pol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30259501
  5. Wang H, Li J, Fu X et al. Effect of simvastatin on expression of VEGF and TGF-beta1 in atherosclerotic animal model of type 2 diabetes mellitus. Experimental and therapeutic medicine 2018; 16:2889-2894. http://www.ncbi.nlm.nih.gov/pubmed/?term=30233664
  6. Lu D, Mai HC, Liang YB et al. Beneficial Role of Rosuvastatin in Blood-Brain Barrier Damage Following Experimental Ischemic Stroke. Frontiers in pharmacology 2018; 9:926. http://www.ncbi.nlm.nih.gov/pubmed/?term=30186167
  7. Hu YB, Hu ED, Fu RQ. Statin Use and Cancer Incidence in Patients with Type 2 Diabetes Mellitus: A Network Meta-Analysis. Gastroenterology research and practice 2018; 2018:8620682. http://www.ncbi.nlm.nih.gov/pubmed/?term=30254671
  8. Ozdogan AI, Ilarslan YD, Kosemehmetoglu K et al. In Vivo Evaluation of Chitosan Based Local Delivery Systems for Atorvastatin in Treatment of Periodontitis. Int J Pharm 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30194012
  9. Bezek S, Brnoliakova Z, Sotnikova R et al. Monotherapy of experimental metabolic syndrome: I. Efficacy and safety. Interdisciplinary toxicology 2017; 10:81-85. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174530
  10. Knezl V, Sotnikova R, Brnoliakova Z et al. Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects. Interdisciplinary toxicology 2017; 10:86-92. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174531
  11. Liu Q, Wang Y, Cheng X. The functional effect of atorvastatin dose-dependent via inflammation factors on acute ST segment elevation myocardial infarction after emergency percutaneous coronary intervention. Journal of cardiovascular medicine (Hagerstown, Md.) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30222665
  12. Shakour N, Bianconi V, Pirro M et al. In silico evidence of direct interaction between statins and beta-amyloid. Journal of cellular biochemistry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30260016
  13. Arian A, Mortazavi Moghadam SG, Kazemi T et al. Trial of Atorvastatin on Serum Interleukin-6, Total Antioxidant Capacity, C-Reactive Protein, and Alpha-1 Antitrypsin in Patients with Chronic Obstructive Pulmonary Disease. Journal of research in pharmacy practice 2018; 7:141-146. http://www.ncbi.nlm.nih.gov/pubmed/?term=30211239
  14. Lopes RD, de Barros ESPGM, de Andrade Jesuino I et al. Timing of Loading Dose of Atorvastatin in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes: Insights From the SECURE-PCI Randomized Clinical Trial. JAMA cardiology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30264159
  15. Sun B, Rui R, Pan H et al. Effect of Combined Use of Astragaloside IV (AsIV) and Atorvastatin (AV) on Expression of PPAR-gamma and Inflammation-Associated Cytokines in Atherosclerosis Rats. Medical science monitor : international medical journal of experimental and clinical research 2018; 24:6229-6236. http://www.ncbi.nlm.nih.gov/pubmed/?term=30190450
  16. Mirzapour H, Panahi HA, Moniri E, Feizbakhsh A. Magnetic nanoparticles modified with organic dendrimers containing methyl methacrylate and ethylene diamine for the microextraction of rosuvastatin. Mikrochimica acta 2018; 185:440. http://www.ncbi.nlm.nih.gov/pubmed/?term=30173349
  17. Nabih ES, El-Kharashi OA. Targeting HMGB1/TLR4 axis and miR-21 by rosuvastatin: role in alleviating cholestatic liver injury in a rat model of bile duct ligation. Naunyn-Schmiedeberg's archives of pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203151
  18. Zhou F, Rao F, Deng YQ et al. Atorvastatin ameliorates the contractile dysfunction of the aorta induced by organ culture. Naunyn-Schmiedeberg's archives of pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30182188
  19. Idzerda NMA, Pena MJ, Parving HH et al. Proteinuria and cholesterol reduction are independently associated with less renal function decline in statin-treated patients; apost hoc analysis of the PLANET trials. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30184238
  20. Li Y, Liu H, Wu Y, Zhu M. Effect of atorvastatin on the apoptosis of human umbilical vein endothelial cells and its drug mechanism. Pak J Pharm Sci 2018; 31:1761-1766. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203776
  21. Liu M, Liu G, Wang M. Comparison and analysis of the therapeutic effect of different statins in the treatment of atherosclerosis. Pak J Pharm Sci 2018; 31:1737-1742. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203772
  22. Zhang QS, Deater M, Phan N et al. Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model. Pediatric blood & cancer 2018:e27460. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255556
  23. Yao GT, Song LP, Xue WH et al. Nano-particle engineered atorvastatin delivery to support mesenchymal stem cell survival in infarcted myocardium. Saudi journal of biological sciences 2018; 25:1016-1021. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174496
  24. Woodcock J, Khan MA. FDA Analysis of Atorvastatin Products Refutes Report of Methyl Ester Impurities. Therapeutic innovation & regulatory science 2014; 48:554-556. http://www.ncbi.nlm.nih.gov/pubmed/?term=30231449
  25. Bolat MS, Bakirtas M, Firat F et al. The effect of atorvastatin on penile intracavernosal pressure and cavernosal morphology in normocholesterolemic rats. Turkish journal of urology 2018:1-6. http://www.ncbi.nlm.nih.gov/pubmed/?term=30183612
  26. Tahta A, Izgi N, Bagci-Onder T et al. Assessment of the MRI and Behavioral Test Results in a Focal Cerebral Ischemia-Reperfusion Model in the Rat after Separate and Combined Use of Mouse-Derived Neural Progenitor Cells, Human-Derived Neural Progenitor Cells and Atorvastatin. Turkish neurosurgery 2018; 28:571-581. http://www.ncbi.nlm.nih.gov/pubmed/?term=30192361
  27. Tang R, Shi J, Li X et al. Corrigendum to "Effects of Atorvastatin on Surgical Treatments of Chronic Subdural Hematoma" [World Neurosurgery 117 (2018) e425-e429]. World neurosurgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30213465
 Basic science
  1. Bayat N, Izadpanah R, Ebrahimi-Barough S et al. The Anti-Angiogenic Effect of Atorvastatin in Glioblastoma Spheroids Tumor Cultured in Fibrin Gel: in 3D in Vitro Model. Asian Pacific journal of cancer prevention : APJCP 2018; 19:2553-2560. http://www.ncbi.nlm.nih.gov/pubmed/?term=30256055
  2. Afrouzian M, Al-Lahham R, Patrikeeva S et al. Role of the Efflux Transporters BCRP and MRP1 in Human Placental Bio-disposition of Pravastatin. Biochem Pharmacol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30217571
  3. Arefieva TI, Filatova AY, Potekhina AV, Shchinova AM. Immunotropic Effects and Proposed Mechanism of Action for 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors (Statins). Biochemistry. Biokhimiia 2018; 83:874-889. http://www.ncbi.nlm.nih.gov/pubmed/?term=30208827
  4. Tirawanchai N, Supapornhemin S, Somkasetrin A et al. Regulatory effect of Phikud Navakot extract on HMG-CoA reductase and LDL-R: potential and alternate agents for lowering blood cholesterol. BMC complementary and alternative medicine 2018; 18:258. http://www.ncbi.nlm.nih.gov/pubmed/?term=30249222
  5. Raafat SN, Amin RM, Elmazar MM et al. The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats. Bone 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30208342
  6. Yao D, Jing T, Niu L et al. Amyloidogenesis Induced by Diet Cholesterol and Copper in a Model Mouse for Alzheimer's Disease and Protection Effects of Zinc and Fluvastatin. Brain research bulletin 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30227236
  7. Luthje P, Walker S, Kamolvit W et al. Statins influence epithelial expression of the antimicrobial peptide LL-37/hCAP-18 independently of the mevalonate pathway. Clinical and experimental immunology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30216432
  8. Ji RC, Eshita Y, Kobayashi T et al. Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis. Clin Exp Metastasis 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255290
  9. Yoshikado T, Toshimoto K, Maeda K et al. PBPK modeling of coproporphyrin I as an endogenous biomarker for drug interactions involving inhibition of hepatic OATP1B1 and OATP1B3. CPT Pharmacometrics Syst Pharmacol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30175555
  10. Toribio M, Fitch KV, Stone L et al. Assessing statin effects on cardiovascular pathways in HIV using a novel proteomics approach: Analysis of data from INTREPID, a randomized controlled trial. EBioMedicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174281
  11. Wang H, Li J, Fu X et al. Effect of simvastatin on expression of VEGF and TGF-beta1 in atherosclerotic animal model of type 2 diabetes mellitus. Experimental and therapeutic medicine 2018; 16:2889-2894. http://www.ncbi.nlm.nih.gov/pubmed/?term=30233664
  12. Pelizzo G, Bussani R, Mazzon E et al. Effects of Simvastatin on Fetal Cardiac Impairment in the Diaphragmatic Experimental Hernia Model. Fetal diagnosis and therapy 2018:1-10. http://www.ncbi.nlm.nih.gov/pubmed/?term=30199868
  13. Lu D, Mai HC, Liang YB et al. Beneficial Role of Rosuvastatin in Blood-Brain Barrier Damage Following Experimental Ischemic Stroke. Frontiers in pharmacology 2018; 9:926. http://www.ncbi.nlm.nih.gov/pubmed/?term=30186167
  14. Cheng L, Wang X, Liu T et al. Modulation of Ion Channels in the Superior Cervical Ganglion Neurons by Myocardial Ischemia and Fluvastatin Treatment. Front Physiol 2018; 9:1157. http://www.ncbi.nlm.nih.gov/pubmed/?term=30246810
  15. Zhang L, Kang W, Lu X et al. Weighted gene co-expression network analysis and connectivity map identifies lovastatin as a treatment option of gastric cancer by inhibiting HDAC2. Gene 2018; 681:15-25. http://www.ncbi.nlm.nih.gov/pubmed/?term=30266498
  16. Agarwal D, Schmader KE, Kossenkov AV et al. Immune response to influenza vaccination in the elderly is altered by chronic medication use. Immunity & ageing : I & A 2018; 15:19. http://www.ncbi.nlm.nih.gov/pubmed/?term=30186359
  17. Mao Z, Wang P, Pan Q et al. Pravastatin alleviates interleukin 1beta-induced cartilage degradation by restoring impaired autophagy associated with MAPK pathway inhibition. Int Immunopharmacol 2018; 64:308-318. http://www.ncbi.nlm.nih.gov/pubmed/?term=30243066
  18. Hadzieva Gigovska M, Petkovska A, Acevska J et al. Comprehensive Assessment of Degradation Behavior of Simvastatin by UHPLC/MS Method, Employing Experimental Design Methodology. International journal of analytical chemistry 2018; 2018:7170539. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174695
  19. Rizvi F, Siddiqui R, DeFranco A et al. Simvastatin reduces TGF-beta1-induced SMAD2/3-dependent human ventricular fibroblasts differentiation: Role of protein phosphatase activation. Int J Cardiol 2018; 270:228-236. http://www.ncbi.nlm.nih.gov/pubmed/?term=30220377
  20. Bezek S, Brnoliakova Z, Sotnikova R et al. Monotherapy of experimental metabolic syndrome: I. Efficacy and safety. Interdisciplinary toxicology 2017; 10:81-85. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174530
  21. Knezl V, Sotnikova R, Brnoliakova Z et al. Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects. Interdisciplinary toxicology 2017; 10:86-92. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174531
  22. Adeli S, Zahmatkesh M, Ansari Dezfouli M. Simvastatin Attenuates Hippocampal MMP-9 Expression in the Streptozotocin-Induced Cognitive Impairment. Iranian biomedical journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30218997
  23. Wu H, Lv W, Pan Q et al. Simvastatin therapy in adolescent mice attenuates HFD-induced depression-like behavior by reducing hippocampal neuroinflammation. Journal of affective disorders 2018; 243:83-95. http://www.ncbi.nlm.nih.gov/pubmed/?term=30236762
  24. Leite GAA, de Barros JWF, Martins ADC, Jr. et al. Ascorbic acid supplementation ameliorates testicular hormonal signaling, sperm production and oxidative stress in male rats exposed to rosuvastatin during pre-puberty. Journal of applied toxicology : JAT 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30240002
  25. Koohestanimobarhan S, Salami S, Imeni V et al. Lipophilic statins antagonistically alter the major epithelial-to-mesenchymal transition signaling pathways in breast cancer stem-like cells via inhibition of the mevalonate pathway. Journal of cellular biochemistry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30191610
  26. Shakour N, Bianconi V, Pirro M et al. In silico evidence of direct interaction between statins and beta-amyloid. Journal of cellular biochemistry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30260016
  27. Pentz R, Kaun C, Thaler B et al. Cardioprotective cytokine interleukin-33 is up-regulated by statins in human cardiac tissue. Journal of cellular and molecular medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30216659
  28. Askarizadeh A, Butler AE, Badiee A, Sahebkar A. Liposomal nanocarriers for statins: A pharmacokinetic and pharmacodynamics appraisal. Journal of cellular physiology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203471
  29. Bahammam MA, Attia MS. Effects of Systemic Simvastatin on the Concentrations of Visfatin, Tumor Necrosis Factor-alpha, and Interleukin-6 in Gingival Crevicular Fluid in Patients with Type 2 Diabetes and Chronic Periodontitis. Journal of immunology research 2018; 2018:8481735. http://www.ncbi.nlm.nih.gov/pubmed/?term=30186882
  30. Bond CM, Tang Y. Engineering Saccharomyces cerevisiae for production of simvastatin. Metabolic engineering 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30213650
  31. Mirzapour H, Panahi HA, Moniri E, Feizbakhsh A. Magnetic nanoparticles modified with organic dendrimers containing methyl methacrylate and ethylene diamine for the microextraction of rosuvastatin. Mikrochimica acta 2018; 185:440. http://www.ncbi.nlm.nih.gov/pubmed/?term=30173349
  32. Minas da Piedade ME, Simoes RG, Bernardes CES et al. Polymorphism in Simvastatin: Twinning, Disorder and Enantiotropic Phase Transitions. Molecular pharmaceutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30230340
  33. Jiang S, Li S, Hu J et al. Combined delivery of angiopoietin-1 gene and simvastatin mediated by anti-intercellular adhesion molecule-1 antibody-conjugated ternary nanoparticles for acute lung injury therapy. Nanomedicine : nanotechnology, biology, and medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30193816
  34. Nabih ES, El-Kharashi OA. Targeting HMGB1/TLR4 axis and miR-21 by rosuvastatin: role in alleviating cholestatic liver injury in a rat model of bile duct ligation. Naunyn-Schmiedeberg's archives of pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203151
  35. Zhang QS, Deater M, Phan N et al. Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model. Pediatric blood & cancer 2018:e27460. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255556
  36. Ferreira Junior DB, Pizziolo VR, Oliveira TT et al. Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis. Revista brasileira de ortopedia 2018; 53:607-613. http://www.ncbi.nlm.nih.gov/pubmed/?term=30245999
  37. Yao GT, Song LP, Xue WH et al. Nano-particle engineered atorvastatin delivery to support mesenchymal stem cell survival in infarcted myocardium. Saudi journal of biological sciences 2018; 25:1016-1021. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174496
  38. Wang C, Ku P, Nie X et al. Effects of simvastatin on the PXR signaling pathway and the liver histology in Mugilogobius abei. The Science of the total environment 2018; 651:399-409. http://www.ncbi.nlm.nih.gov/pubmed/?term=30240922
  39. Bolat MS, Bakirtas M, Firat F et al. The effect of atorvastatin on penile intracavernosal pressure and cavernosal morphology in normocholesterolemic rats. Turkish journal of urology 2018:1-6. http://www.ncbi.nlm.nih.gov/pubmed/?term=30183612
  40. Tahta A, Izgi N, Bagci-Onder T et al. Assessment of the MRI and Behavioral Test Results in a Focal Cerebral Ischemia-Reperfusion Model in the Rat after Separate and Combined Use of Mouse-Derived Neural Progenitor Cells, Human-Derived Neural Progenitor Cells and Atorvastatin. Turkish neurosurgery 2018; 28:571-581. http://www.ncbi.nlm.nih.gov/pubmed/?term=30192361 

Cancer

  1. Bayat N, Izadpanah R, Ebrahimi-Barough S et al. The Anti-Angiogenic Effect of Atorvastatin in Glioblastoma Spheroids Tumor Cultured in Fibrin Gel: in 3D in Vitro Model. Asian Pacific journal of cancer prevention : APJCP 2018; 19:2553-2560. http://www.ncbi.nlm.nih.gov/pubmed/?term=30256055
  2. Ji RC, Eshita Y, Kobayashi T et al. Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis. Clin Exp Metastasis 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255290
  3. Allott EH, Freeman MR, Freedland SJ. Statin Therapy to Improve Prostate Cancer Outcomes: Who, When, and for How Long? European urology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30177293
  4. Hu YB, Hu ED, Fu RQ. Statin Use and Cancer Incidence in Patients with Type 2 Diabetes Mellitus: A Network Meta-Analysis. Gastroenterology research and practice 2018; 2018:8620682. http://www.ncbi.nlm.nih.gov/pubmed/?term=30254671
  5. Zhang L, Kang W, Lu X et al. Weighted gene co-expression network analysis and connectivity map identifies lovastatin as a treatment option of gastric cancer by inhibiting HDAC2. Gene 2018; 681:15-25. http://www.ncbi.nlm.nih.gov/pubmed/?term=30266498
  6. Seliger C, Hau P. Drug Repurposing of Metabolic Agents in Malignant Glioma. Int J Mol Sci 2018; 19. http://www.ncbi.nlm.nih.gov/pubmed/?term=30223473
  7. Koohestanimobarhan S, Salami S, Imeni V et al. Lipophilic statins antagonistically alter the major epithelial-to-mesenchymal transition signaling pathways in breast cancer stem-like cells via inhibition of the mevalonate pathway. Journal of cellular biochemistry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30191610
  8. Nowak C, Arnlov J. A Mendelian randomization study of the effects of blood lipids on breast cancer risk. Nature communications 2018; 9:3957. http://www.ncbi.nlm.nih.gov/pubmed/?term=30262900
  9. Zhang QS, Deater M, Phan N et al. Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model. Pediatric blood & cancer 2018:e27460. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255556

CVD

  1. Ambrosy AP, Cerbin LP, Fudim M et al. Natural History of Patients Postacute Coronary Syndrome Based on Heart Failure Status. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30180960
  2. Lee MS, Duan L, Clare R et al. Comparison of Effects of Statin Use on Mortality in Patients With Heart Failure and Preserved Versus Reduced Left Ventricular Ejection Fraction. Am J Cardiol 2018; 122:405-412. http://www.ncbi.nlm.nih.gov/pubmed/?term=30201108
  3. Olmastroni E, Shlyakhto EV, Konradi AO et al. Epidemiology of cardiovascular risk factors in two population-based studies. Atherosclerosis. Supplements 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30177370
  4. Alkhalil M, Biasiolli L, Akbar N et al. T2 mapping MRI technique quantifies carotid plaque lipid, and its depletion after statin initiation, following acute myocardial infarction. Atherosclerosis 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30227984
  5. Jubran A, Zetser A, Zafrir B. Lipoprotein(a) screening in young and middle-aged patients presenting with acute coronary syndrome. Cardiology journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30234895
  6. Hernandez-Mijares A, Ascaso JF, Blasco M et al. Residual cardiovascular risk of lipid origin. Components and pathophysiological aspects. Clin Investig Arterioscler 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30262442
  7. McGurnaghan S, Blackbourn LAK, Mocevic E et al. Cardiovascular disease prevalence and risk factor prevalence in Type 2 diabetes: a contemporary analysis. Diabetic medicine : a journal of the British Diabetic Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30246473
  8. Nichols GA, Philip S, Reynolds K et al. Increased Residual Cardiovascular Risk in Patients with Diabetes and High vs. Normal Triglycerides Despite Statin-Controlled LDL Cholesterol. Diabetes Obes Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30225881
  9. Sobhy M, El Etriby A, El Nashar A et al. Prevalence of lipid abnormalities and cholesterol target value attainment in Egyptian patients presenting with an acute coronary syndrome. The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology 2018; 70:129-134. http://www.ncbi.nlm.nih.gov/pubmed/?term=30190636
  10. Lopes RD, de Barros ESPGM, de Andrade Jesuino I et al. Timing of Loading Dose of Atorvastatin in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes: Insights From the SECURE-PCI Randomized Clinical Trial. JAMA cardiology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30264159
  11. Peng H, Yang Y, Zhao Y, Xiao H. The effect of statins on the recurrence rate of atrial fibrillation after catheter ablation: A meta-analysis. Pacing and clinical electrophysiology : PACE 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30191566
  12. Lee J, Lee S. Comparative Effectiveness of Combination Therapy with Statins and Angiotensin-Converting Enzyme Inhibitors versus Angiotensin II Receptor Blockers in Patients with Coronary Heart Disease: A Nationwide Population-Based Cohort Study in Korea. Pharmacotherapy 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30225928
  13. Gitt AK, Rieber J, Hambrecht R et al. Do acute coronary events affect lipid management and cholesterol goal attainment in Germany? : Results from the Dyslipidemia International study II. Wien Klin Wochenschr 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30178071

Endothelium/inflammation

  1. Arefieva TI, Filatova AY, Potekhina AV, Shchinova AM. Immunotropic Effects and Proposed Mechanism of Action for 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors (Statins). Biochemistry. Biokhimiia 2018; 83:874-889. http://www.ncbi.nlm.nih.gov/pubmed/?term=30208827
  2. Luthje P, Walker S, Kamolvit W et al. Statins influence epithelial expression of the antimicrobial peptide LL-37/hCAP-18 independently of the mevalonate pathway. Clinical and experimental immunology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30216432
  3. Mao Z, Wang P, Pan Q et al. Pravastatin alleviates interleukin 1beta-induced cartilage degradation by restoring impaired autophagy associated with MAPK pathway inhibition. Int Immunopharmacol 2018; 64:308-318. http://www.ncbi.nlm.nih.gov/pubmed/?term=30243066
  4. Sakata K, Gamou T, Tada H et al. Low Baseline High-Sensitive C-Reactive Protein is Associated with Coronary Atherosclerosis Regression: Insights from the MILLION Study. J Atheroscler Thromb 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30249940
  5. Arian A, Mortazavi Moghadam SG, Kazemi T et al. Trial of Atorvastatin on Serum Interleukin-6, Total Antioxidant Capacity, C-Reactive Protein, and Alpha-1 Antitrypsin in Patients with Chronic Obstructive Pulmonary Disease. Journal of research in pharmacy practice 2018; 7:141-146. http://www.ncbi.nlm.nih.gov/pubmed/?term=30211239
  6. Turk Veselic M, Erzen B, Hanzel J et al. Improving Arterial Wall Characteristics in Patients After Myocardial Infarction with a Very Low Dose of Fluvastatin and Valsartan: A Proof-of-Concept Study. Medical science monitor : international medical journal of experimental and clinical research 2018; 24:6892-6899. http://www.ncbi.nlm.nih.gov/pubmed/?term=30266894

Ethnicity

  1. Sobhy M, El Etriby A, El Nashar A et al. Prevalence of lipid abnormalities and cholesterol target value attainment in Egyptian patients presenting with an acute coronary syndrome. The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology 2018; 70:129-134. http://www.ncbi.nlm.nih.gov/pubmed/?term=30190636
  2. Poh KK, Ambegaonkar B, Baxter CA et al. Low-density lipoprotein cholesterol target attainment in patients with stable or acute coronary heart disease in the Asia-Pacific region: results from the Dyslipidemia International Study II. Eur J Prev Cardiol 2018:2047487318798927. http://www.ncbi.nlm.nih.gov/pubmed/?term=30198749
  3. Wang H, Wang S, Tao Y, Sun Y. Further insight into 10-year CVD risk evaluation and recommended eligibility for statin therapy in Chinese population: Comparison of cardiovascular risk prediction models and their guidelines. Int J Cardiol 2018; 271:343. http://www.ncbi.nlm.nih.gov/pubmed/?term=30223366
  4. Jiao Y, Cai S, Lin J et al. Statin-naive anti-HMGCR antibody-mediated necrotizing myopathy in China. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30205933
  5. Aburuz S, Al-Bekairy A, Alqahtani AA et al. Comparison of the application of treatment Panel III and American College of Cardiology/American heart Association guidelines for blood cholesterol treatment in Saudi Arabia. J Saudi Heart Assoc 2018; 30:349-355. http://www.ncbi.nlm.nih.gov/pubmed/?term=30228788
  6. Nam CW, Kim DS, Li J et al. Efficacy and safety of alirocumab in Korean patients with hypercholesterolemia and high cardiovascular risk: subanalysis of the ODYSSEY-KT study. The Korean journal of internal medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30257549
  7. Chiu HT, Shen LJ, Chen YC et al. Effect of statin use on the risk of medically attended acute respiratory illness among influenza vaccinated elderly. Vaccine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174239

Genetics

  1. Hui SK, Lindale E, Sun L, Ruel M. Genetics of coronary artery disease: should they impact the choice of revascularization? Current opinion in cardiology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30188420
  2. Mitchell D, Guertin JR, LeLorier J. Value of a Hypothetical Pharmacogenomic Test for the Diagnosis of Statin-Induced Myopathy in Patients at High Cardiovascular Risk. Molecular diagnosis & therapy 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30218425
  3. Nowak C, Arnlov J. A Mendelian randomization study of the effects of blood lipids on breast cancer risk. Nature communications 2018; 9:3957. http://www.ncbi.nlm.nih.gov/pubmed/?term=30262900
  4. Xiang Q, Chen SQ, Ma LY et al. Association between SLCO1B1 T521C polymorphism and risk of statin-induced myopathy: a meta-analysis. Pharmacogenomics J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30250148
  5. Mohajeri M, Banach M, Atkin SL et al. MicroRNAs: Novel Molecular Targets and Response Modulators of Statin Therapy. Trends in pharmacological sciences 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30249403

Guidelines

  1. Sobhy M, El Etriby A, El Nashar A et al. Prevalence of lipid abnormalities and cholesterol target value attainment in Egyptian patients presenting with an acute coronary syndrome. The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology 2018; 70:129-134. http://www.ncbi.nlm.nih.gov/pubmed/?term=30190636
  2. Wang H, Wang S, Tao Y, Sun Y. Further insight into 10-year CVD risk evaluation and recommended eligibility for statin therapy in Chinese population: Comparison of cardiovascular risk prediction models and their guidelines. Int J Cardiol 2018; 271:343. http://www.ncbi.nlm.nih.gov/pubmed/?term=30223366
  3. Aburuz S, Al-Bekairy A, Alqahtani AA et al. Comparison of the application of treatment Panel III and American College of Cardiology/American heart Association guidelines for blood cholesterol treatment in Saudi Arabia. J Saudi Heart Assoc 2018; 30:349-355. http://www.ncbi.nlm.nih.gov/pubmed/?term=30228788
  4. Lin JS, Evans CV, Johnson E et al. U.S. Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews. In: Nontraditional Risk Factors in Cardiovascular Disease Risk Assessment: A Systematic Evidence Report for the U.S. Preventive Services Task Force. Rockville, MD: Agency for Healthcare Research and Quality (US); 2018. https://www.ncbi.nlm.nih.gov/pubmed/29998301 

LDL- related parameters

  1. Jubran A, Zetser A, Zafrir B. Lipoprotein(a) screening in young and middle-aged patients presenting with acute coronary syndrome. Cardiology journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30234895
  2. Hernandez-Mijares A, Ascaso JF, Blasco M et al. Residual cardiovascular risk of lipid origin. Components and pathophysiological aspects. Clin Investig Arterioscler 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30262442
  3. Sobhy M, El Etriby A, El Nashar A et al. Prevalence of lipid abnormalities and cholesterol target value attainment in Egyptian patients presenting with an acute coronary syndrome. The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology 2018; 70:129-134. http://www.ncbi.nlm.nih.gov/pubmed/?term=30190636
  4. Poh KK, Ambegaonkar B, Baxter CA et al. Low-density lipoprotein cholesterol target attainment in patients with stable or acute coronary heart disease in the Asia-Pacific region: results from the Dyslipidemia International Study II. Eur J Prev Cardiol 2018:2047487318798927. http://www.ncbi.nlm.nih.gov/pubmed/?term=30198749 

Meta-analyses

  1. Zhou X, Dai J, Xu X et al. Comparative Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease: A Network Meta-Analysis. Angiology 2018:3319718801246. http://www.ncbi.nlm.nih.gov/pubmed/?term=30261736
  2. Li X, Sun S, Xu X et al. The Association between Genetic Polymorphisms and Simvastatin-Induced Myopathy: A Narrative Synthesis of Evidence. Drug research 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30193394
  3. Hu YB, Hu ED, Fu RQ. Statin Use and Cancer Incidence in Patients with Type 2 Diabetes Mellitus: A Network Meta-Analysis. Gastroenterology research and practice 2018; 2018:8620682. http://www.ncbi.nlm.nih.gov/pubmed/?term=30254671
  4. Peng H, Yang Y, Zhao Y, Xiao H. The effect of statins on the recurrence rate of atrial fibrillation after catheter ablation: A meta-analysis. Pacing and clinical electrophysiology : PACE 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30191566
  5. Xiang Q, Chen SQ, Ma LY et al. Association between SLCO1B1 T521C polymorphism and risk of statin-induced myopathy: a meta-analysis. Pharmacogenomics J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30250148

Metabolic Syndrome - Diabetes

  1. Ramos R, Comas-Cufi M, Marti-Lluch R et al. Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study. Bmj 2018; 362:k3359. http://www.ncbi.nlm.nih.gov/pubmed/?term=30185425
  2. McGurnaghan S, Blackbourn LAK, Mocevic E et al. Cardiovascular disease prevalence and risk factor prevalence in Type 2 diabetes: a contemporary analysis. Diabetic medicine : a journal of the British Diabetic Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30246473
  3. Wang H, Li J, Fu X et al. Effect of simvastatin on expression of VEGF and TGF-beta1 in atherosclerotic animal model of type 2 diabetes mellitus. Experimental and therapeutic medicine 2018; 16:2889-2894. http://www.ncbi.nlm.nih.gov/pubmed/?term=30233664
  4. Bezek S, Brnoliakova Z, Sotnikova R et al. Monotherapy of experimental metabolic syndrome: I. Efficacy and safety. Interdisciplinary toxicology 2017; 10:81-85. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174530
  5. Bahammam MA, Attia MS. Effects of Systemic Simvastatin on the Concentrations of Visfatin, Tumor Necrosis Factor-alpha, and Interleukin-6 in Gingival Crevicular Fluid in Patients with Type 2 Diabetes and Chronic Periodontitis. Journal of immunology research 2018; 2018:8481735. http://www.ncbi.nlm.nih.gov/pubmed/?term=30186882

New Treatments

  1. Davidson ER, Snider MJ, Bartsch K et al. Tolerance of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) Inhibitors in Patients With Self-Reported Statin Intolerance. Journal of pharmacy practice 2018:897190018799218. http://www.ncbi.nlm.nih.gov/pubmed/?term=30222031
  2. Nam CW, Kim DS, Li J et al. Efficacy and safety of alirocumab in Korean patients with hypercholesterolemia and high cardiovascular risk: subanalysis of the ODYSSEY-KT study. The Korean journal of internal medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30257549
  3. Robinson JG, Watson KE. Identifying Patients for Nonstatin Therapy. Rev Cardiovasc Med 2018; 19:S1-s8. http://www.ncbi.nlm.nih.gov/pubmed/?term=30207552 

Other

  1. Majka DS, Lee JY, Peprah YA et al. Changes in Care After Implementing a Multifaceted Intervention to Improve Preventive Cardiology Practice in Rheumatoid Arthritis. American journal of medical quality : the official journal of the American College of Medical Quality 2018:1062860618798719. http://www.ncbi.nlm.nih.gov/pubmed/?term=30196708
  2. Jeemon P, Gupta R, Onen C et al. Management of Hypertension and Dyslipidemia for Primary Prevention of Cardiovascular Disease. In: Cardiovascular, Respiratory, and Related Disorders. Edited by: rd, Prabhakaran D, Anand S et al. Washington (DC): The International Bank for Reconstruction and Development / The World Bank.
  3. Baldassari LE, Fox RJ. Therapeutic Advances and Challenges in the Treatment of Progressive Multiple Sclerosis. Drugs 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255442
  4. Krysiak R, Drosdzol-Cop AB, Skrzypulec-Plinta V, Okopien B. The effect of atorvastatin on sexual function and depressive symptoms in young women with elevated cholesterol levels: a pilot study. Endokrynol Pol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30259501
  5. Ravnskov U, de Lorgeril M, Diamond DM et al. LDL-C Does Not Cause Cardiovascular Disease: a comprehensive review of current literature. Expert Rev Clin Pharmacol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30198808
  6. Beltowski J. Epicardial adipose tissue: The new target for statin therapy. Int J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30196996
  7. Andrade C. The Use of Statins for Antipsychotic Augmentation in Schizophrenia: Examination of Meta-Analyses With Flawed Methods and Conclusions. The Journal of clinical psychiatry 2018; 79. http://www.ncbi.nlm.nih.gov/pubmed/?term=30256553
  8. Pawar AM, LaPlante KL, Timbrook TT, Caffrey AR. Optimal duration for continuation of statin therapy in bacteremic patients. Therapeutic advances in infectious disease 2018; 5:83-90. http://www.ncbi.nlm.nih.gov/pubmed/?term=30224951

Pleiotropic effects of statins

  1. Patyk I, Rybacki C, Kalicka A et al. Simvastatin Therapy and Bronchoalveolar Lavage Fluid Biomarkers in Chronic Obstructive Pulmonary Disease. Advances in experimental medicine and biology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255302
  2. Zhou X, Dai J, Xu X et al. Comparative Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease: A Network Meta-Analysis. Angiology 2018:3319718801246. http://www.ncbi.nlm.nih.gov/pubmed/?term=30261736
  3. Arefieva TI, Filatova AY, Potekhina AV, Shchinova AM. Immunotropic Effects and Proposed Mechanism of Action for 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors (Statins). Biochemistry. Biokhimiia 2018; 83:874-889. http://www.ncbi.nlm.nih.gov/pubmed/?term=30208827
  4. Raafat SN, Amin RM, Elmazar MM et al. The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats. Bone 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30208342
  5. Lee MS, Tadwalkar RV, Fearon WF et al. Cardiac allograft vasculopathy: A review. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30265435
  6. Korpela T, Cardenas-Jaen K, Archibugi L et al. Chronic use of statins and risk of post-ERCP acute pancreatitis (STARK): Study protocol for an international multicenter prospective cohort study. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30224317
  7. Baldassari LE, Fox RJ. Therapeutic Advances and Challenges in the Treatment of Progressive Multiple Sclerosis. Drugs 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255442
  8. Wang H, Li J, Fu X et al. Effect of simvastatin on expression of VEGF and TGF-beta1 in atherosclerotic animal model of type 2 diabetes mellitus. Experimental and therapeutic medicine 2018; 16:2889-2894. http://www.ncbi.nlm.nih.gov/pubmed/?term=30233664
  9. Pelizzo G, Bussani R, Mazzon E et al. Effects of Simvastatin on Fetal Cardiac Impairment in the Diaphragmatic Experimental Hernia Model. Fetal diagnosis and therapy 2018:1-10. http://www.ncbi.nlm.nih.gov/pubmed/?term=30199868
  10. Cheng L, Wang X, Liu T et al. Modulation of Ion Channels in the Superior Cervical Ganglion Neurons by Myocardial Ischemia and Fluvastatin Treatment. Front Physiol 2018; 9:1157. http://www.ncbi.nlm.nih.gov/pubmed/?term=30246810
  11. Mao Z, Wang P, Pan Q et al. Pravastatin alleviates interleukin 1beta-induced cartilage degradation by restoring impaired autophagy associated with MAPK pathway inhibition. Int Immunopharmacol 2018; 64:308-318. http://www.ncbi.nlm.nih.gov/pubmed/?term=30243066
  12. Rizvi F, Siddiqui R, DeFranco A et al. Simvastatin reduces TGF-beta1-induced SMAD2/3-dependent human ventricular fibroblasts differentiation: Role of protein phosphatase activation. Int J Cardiol 2018; 270:228-236. http://www.ncbi.nlm.nih.gov/pubmed/?term=30220377
  13. Ozdogan AI, Ilarslan YD, Kosemehmetoglu K et al. In Vivo Evaluation of Chitosan Based Local Delivery Systems for Atorvastatin in Treatment of Periodontitis. Int J Pharm 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30194012
  14. Adeli S, Zahmatkesh M, Ansari Dezfouli M. Simvastatin Attenuates Hippocampal MMP-9 Expression in the Streptozotocin-Induced Cognitive Impairment. Iranian biomedical journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30218997
  15. Wu H, Lv W, Pan Q et al. Simvastatin therapy in adolescent mice attenuates HFD-induced depression-like behavior by reducing hippocampal neuroinflammation. Journal of affective disorders 2018; 243:83-95. http://www.ncbi.nlm.nih.gov/pubmed/?term=30236762
  16. Leite GAA, de Barros JWF, Martins ADC, Jr. et al. Ascorbic acid supplementation ameliorates testicular hormonal signaling, sperm production and oxidative stress in male rats exposed to rosuvastatin during pre-puberty. Journal of applied toxicology : JAT 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30240002
  17. Oh TK, Park HY, Shin HJ et al. The Role of Perioperative Statin Use in the Prevention of Delirium After Total Knee Replacement Under Spinal Anesthesia. The Journal of arthroplasty 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30236494
  18. Pentz R, Kaun C, Thaler B et al. Cardioprotective cytokine interleukin-33 is up-regulated by statins in human cardiac tissue. Journal of cellular and molecular medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30216659
  19. Bahammam MA, Attia MS. Effects of Systemic Simvastatin on the Concentrations of Visfatin, Tumor Necrosis Factor-alpha, and Interleukin-6 in Gingival Crevicular Fluid in Patients with Type 2 Diabetes and Chronic Periodontitis. Journal of immunology research 2018; 2018:8481735. http://www.ncbi.nlm.nih.gov/pubmed/?term=30186882
  20. Arian A, Mortazavi Moghadam SG, Kazemi T et al. Trial of Atorvastatin on Serum Interleukin-6, Total Antioxidant Capacity, C-Reactive Protein, and Alpha-1 Antitrypsin in Patients with Chronic Obstructive Pulmonary Disease. Journal of research in pharmacy practice 2018; 7:141-146. http://www.ncbi.nlm.nih.gov/pubmed/?term=30211239
  21. Jorge AM, Lu N, Keller SF et al. The Effect of Statin Use on Mortality in Systemic Autoimmune Rheumatic Diseases. The Journal of rheumatology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30173155
  22. Khalil S, Bardawil T, Saade S et al. Use of Topical Glycolic Acid Plus a Lovastatin-Cholesterol Combination Cream for the Treatment of Autosomal Recessive Congenital Ichthyoses. JAMA dermatology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30208477
  23. Roopmani P, Krishnan UM. Harnessing the pleiotropic effects of atorvastatin-fenofibrate combination for cardiovascular stents. Materials science & engineering. C, Materials for biological applications 2018; 92:875-891. http://www.ncbi.nlm.nih.gov/pubmed/?term=30184817
  24. Sun B, Rui R, Pan H et al. Effect of Combined Use of Astragaloside IV (AsIV) and Atorvastatin (AV) on Expression of PPAR-gamma and Inflammation-Associated Cytokines in Atherosclerosis Rats. Medical science monitor : international medical journal of experimental and clinical research 2018; 24:6229-6236. http://www.ncbi.nlm.nih.gov/pubmed/?term=30190450
  25. Peng H, Yang Y, Zhao Y, Xiao H. The effect of statins on the recurrence rate of atrial fibrillation after catheter ablation: A meta-analysis. Pacing and clinical electrophysiology : PACE 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30191566
  26. Song L, Zou G, Wang X. Effect of doxycycline and atorvastatin on improving exercise tolerance in patients with angina pectoris. Pak J Pharm Sci 2018; 31:1731-1735. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203771
  27. Zou G, Song L, Chang L, Wang H. Comparison and analysis of statins drug use in the treatment of diastolic dysfunction in patients. Pak J Pharm Sci 2018; 31:1725-1730. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203770
  28. Ferreira Junior DB, Pizziolo VR, Oliveira TT et al. Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis. Revista brasileira de ortopedia 2018; 53:607-613. http://www.ncbi.nlm.nih.gov/pubmed/?term=30245999
  29. Mohajeri M, Banach M, Atkin SL et al. MicroRNAs: Novel Molecular Targets and Response Modulators of Statin Therapy. Trends in pharmacological sciences 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30249403 

Primary Prevention

  1. Ramos R, Comas-Cufi M, Marti-Lluch R et al. Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study. Bmj 2018; 362:k3359. http://www.ncbi.nlm.nih.gov/pubmed/?term=30185425
  2. Orkaby AR, Rich MW, Sun R et al. Pravastatin for Primary Prevention in Older Adults: Restricted Mean Survival Time Analysis. J Am Geriatr Soc 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30251369
  3. Firnhaber JM. CV risk prediction tools: Imperfect, Yes, but are they serviceable? The Journal of family practice 2018; 67:E3-e8. http://www.ncbi.nlm.nih.gov/pubmed/?term=30216402

Registry data

  1. Lee MS, Duan L, Clare R et al. Comparison of Effects of Statin Use on Mortality in Patients With Heart Failure and Preserved Versus Reduced Left Ventricular Ejection Fraction. Am J Cardiol 2018; 122:405-412. http://www.ncbi.nlm.nih.gov/pubmed/?term=30201108
  2. Martinez AI, Freeman PR, Moga DC. Statin Use and Gastrointestinal Hemorrhage: A Large Retrospective Cohort Study. Am J Cardiovasc Drugs 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255477
  3. Zhou X, Dai J, Xu X et al. Comparative Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease: A Network Meta-Analysis. Angiology 2018:3319718801246. http://www.ncbi.nlm.nih.gov/pubmed/?term=30261736
  4. Olmastroni E, Shlyakhto EV, Konradi AO et al. Epidemiology of cardiovascular risk factors in two population-based studies. Atherosclerosis. Supplements 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30177370
  5. Chung CM, Lin MS, Liu CH et al. Discontinuing or continuing statin following intracerebral hemorrhage from the view of a national cohort study. Atherosclerosis 2018; 278:15-22. http://www.ncbi.nlm.nih.gov/pubmed/?term=30236866
  6. Shameer K, Perez-Rodriguez MM, Bachar R et al. Pharmacological risk factors associated with hospital readmission rates in a psychiatric cohort identified using prescriptome data mining. BMC medical informatics and decision making 2018; 18:79. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255805
  7. Ramos R, Comas-Cufi M, Marti-Lluch R et al. Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study. Bmj 2018; 362:k3359. http://www.ncbi.nlm.nih.gov/pubmed/?term=30185425
  8. Mickiewicz A, Borowiec-Wolna J, Bachorski W et al. Long-term lipoprotein apheresis in the treatment of severe familial hypercholesterolemia refractory to high intensity statin therapy: Three year experience at a lipoprotein apheresis centre. Cardiology journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30234904
  9. Ooi KG, Lee MH, Burlutsky G et al. Association of dyslipidemia and oral statin use, and dry eye disease symptoms in the Blue Mountains Eye Study. Clinical & experimental ophthalmology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203595
  10. Range JT, LaFontaine PR, Ryder PT, Polston M. Factors Associated With Adherence to Statin Medications of Patients Enrolled in a Self-insured University Health Plan. Clinical therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30231972
  11. McGurnaghan S, Blackbourn LAK, Mocevic E et al. Cardiovascular disease prevalence and risk factor prevalence in Type 2 diabetes: a contemporary analysis. Diabetic medicine : a journal of the British Diabetic Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30246473
  12. Nichols GA, Philip S, Reynolds K et al. Increased Residual Cardiovascular Risk in Patients with Diabetes and High vs. Normal Triglycerides Despite Statin-Controlled LDL Cholesterol. Diabetes Obes Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30225881
  13. Konig M, Gollasch M, Rosada A et al. Antihypertensive Treatment Patterns and Blood Pressure Control in Older Adults: Results from the Berlin Aging Study II. Drugs Aging 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30187292
  14. Osawa K, Trejo MEP, Nakanishi R et al. Coronary artery calcium and carotid artery intima-media thickness for the prediction of stroke and benefit from statins. Eur J Prev Cardiol 2018:2047487318798058. http://www.ncbi.nlm.nih.gov/pubmed/?term=30183342
  15. Huang TM, Wu VC, Lin YF et al. Effects of Statin Use in Advanced Chronic Kidney Disease Patients. Journal of clinical medicine 2018; 7. http://www.ncbi.nlm.nih.gov/pubmed/?term=30227675
  16. Zhao FL, Mi DH, Zhang CQ et al. A cohort study of isolated brainstem infarction based on head MR imaging and clinical findings. J Int Med Res 2018:300060518788253. http://www.ncbi.nlm.nih.gov/pubmed/?term=30246581
  17. Davidson ER, Snider MJ, Bartsch K et al. Tolerance of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) Inhibitors in Patients With Self-Reported Statin Intolerance. Journal of pharmacy practice 2018:897190018799218. http://www.ncbi.nlm.nih.gov/pubmed/?term=30222031
  18. Jorge AM, Lu N, Keller SF et al. The Effect of Statin Use on Mortality in Systemic Autoimmune Rheumatic Diseases. The Journal of rheumatology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30173155
  19. Wall HK, Ritchey MD, Gillespie C et al. Vital Signs: Prevalence of Key Cardiovascular Disease Risk Factors for Million Hearts 2022 - United States, 2011-2016. MMWR. Morbidity and mortality weekly report 2018; 67:983-991. http://www.ncbi.nlm.nih.gov/pubmed/?term=30188885
  20. Lee J, Lee S. Comparative Effectiveness of Combination Therapy with Statins and Angiotensin-Converting Enzyme Inhibitors versus Angiotensin II Receptor Blockers in Patients with Coronary Heart Disease: A Nationwide Population-Based Cohort Study in Korea. Pharmacotherapy 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30225928
  21. Pawar AM, LaPlante KL, Timbrook TT, Caffrey AR. Optimal duration for continuation of statin therapy in bacteremic patients. Therapeutic advances in infectious disease 2018; 5:83-90. http://www.ncbi.nlm.nih.gov/pubmed/?term=30224951
  22. Chiu HT, Shen LJ, Chen YC et al. Effect of statin use on the risk of medically attended acute respiratory illness among influenza vaccinated elderly. Vaccine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174239

Renal Disease

  1. Huang TM, Wu VC, Lin YF et al. Effects of Statin Use in Advanced Chronic Kidney Disease Patients. Journal of clinical medicine 2018; 7. http://www.ncbi.nlm.nih.gov/pubmed/?term=30227675
  2. Idzerda NMA, Pena MJ, Parving HH et al. Proteinuria and cholesterol reduction are independently associated with less renal function decline in statin-treated patients; apost hoc analysis of the PLANET trials. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30184238

Safety and side effects

  1. Balestrino M, Adriano E. Statin-induced myopathy prevented by creatine administration. BMJ case reports 2018; 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30150340
  2. Feng P, Zhao L, Guo F et al. The enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins. Chemico-biological interactions 2018; 293:115-123. http://www.ncbi.nlm.nih.gov/pubmed/?term=30086269
  3. Eljaaly K, Alshehri S, Bhattacharjee S et al. Contraindicated drug-drug interactions associated with oral antimicrobial agents prescribed in the ambulatory care setting in the United States. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30107284
  4. Vassy JL, Chun S, Advani S et al. Impact of SLCO1B1 pharmacogenetic testing on patient and healthcare outcomes: A systematic review. Clinical pharmacology and therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30137643
  5. Dein E, Manno R, Syed A et al. Ranolazine-induced Elevation of Creatinine Kinase in the Absence of Statin Usage. Cureus 2018; 10:e2832. http://www.ncbi.nlm.nih.gov/pubmed/?term=30131925
  6. Pasnoor M, Barohn RJ, Dimachkie MM. Toxic myopathies. Current opinion in neurology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30080718
  7. Choi Y, Lee S, Jang IJ, Yu KS. Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers. Drug design, development and therapy 2018; 12:2301-2309. http://www.ncbi.nlm.nih.gov/pubmed/?term=30087555
  8. Mast N, Bederman IR, Pikuleva IA. Retinal Cholesterol Content is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol. Drug metabolism and disposition: the biological fate of chemicals 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30115644
  9. Bostanitis I, Tsalidou M. Atorvastatin induced gynecomastia in a dyslipidemic patient. A case report. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30145234
  10. McPheeters CM, Wiedmar JA, Pinkston CM, Weant KA. Implications of Statin Use on Vasopressor Therapy in the Setting of Septic Shock. Hospital pharmacy 2018; 53:152-156. http://www.ncbi.nlm.nih.gov/pubmed/?term=30147135
  11. Riaz R, Merchant AZ, Ul Haq MS et al. Statins everyday versus alternate days: Is there a difference in myalgia rates? Indian Heart J 2018; 70:492-496. http://www.ncbi.nlm.nih.gov/pubmed/?term=30170642
  12. Verdoia M, Nardin M, Negro F et al. Impact of statin therapy on the immature platelet count in patients with coronary artery disease: A single centre cohort study. Int J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30150123
  13. Yagi S, Kondo D, Ise T et al. Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome. J Atheroscler Thromb 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30135329
  14. Leite GAA, Figueiredo TM, Pacheco TL et al. Reproductive outcomes in rat female offspring from male rats co-exposed to rosuvastatin and ascorbic acid during pre-puberty. Journal of toxicology and environmental health. Part A 2018:1-20. http://www.ncbi.nlm.nih.gov/pubmed/?term=30081759
  15. Zhang X, Hong S, Yen R et al. A system to monitor statin-induced myopathy in individual engineered skeletal muscle myobundles. Lab on a chip 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30112530
  16. Wang Y, Jin Y, Yun X et al. Co-administration with simvastatin or lovastatin alters the pharmacokinetic profile of sinomenine in rats through cytochrome P450-mediated pathways. Life sciences 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30096386
  17. Carvalho AAS, Silva VGD, Vieira TF et al. Proposed cut-off for reactivity of anti-HMGCR and anti-SRP antibodies in patients statin-exposed and statin-unexposed. Medicine (Baltimore) 2018; 97:e11858. http://www.ncbi.nlm.nih.gov/pubmed/?term=30170376
  18. Ciric D, Martinovic T, Petricevic S et al. Metformin exacerbates and simvastatin attenuates myelin damage in high fat diet-fed C57BL/6 J mice. Neuropathology : official journal of the Japanese Society of Neuropathology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30123961
  19. Soko ND, Chimusa E, Masimirembwa C, Dandara C. An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C. Pharmacogenomics J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30100615
  20. Choi JY, Choi CU, Hwang SY et al. Effect of Pitavastatin Compared with Atorvastatin and Rosuvastatin on New-Onset Diabetes Mellitus in Patients With Acute Myocardial Infarction. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30217375
  21. Martinez AI, Freeman PR, Moga DC. Statin Use and Gastrointestinal Hemorrhage: A Large Retrospective Cohort Study. Am J Cardiovasc Drugs 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255477
  22. Shameer K, Perez-Rodriguez MM, Bachar R et al. Pharmacological risk factors associated with hospital readmission rates in a psychiatric cohort identified using prescriptome data mining. BMC medical informatics and decision making 2018; 18:79. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255805
  23. Ooi KG, Lee MH, Burlutsky G et al. Association of dyslipidemia and oral statin use, and dry eye disease symptoms in the Blue Mountains Eye Study. Clinical & experimental ophthalmology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203595
  24. Shahbaz A, Mahendhar R, Fransawy Alkomos M et al. Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin. Cureus 2018; 10:e2965. http://www.ncbi.nlm.nih.gov/pubmed/?term=30210953
  25. Li X, Sun S, Xu X et al. The Association between Genetic Polymorphisms and Simvastatin-Induced Myopathy: A Narrative Synthesis of Evidence. Drug research 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30193394
  26. Krysiak R, Drosdzol-Cop AB, Skrzypulec-Plinta V, Okopien B. The effect of atorvastatin on sexual function and depressive symptoms in young women with elevated cholesterol levels: a pilot study. Endokrynol Pol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30259501
  27. Cheng KH, Lin JR, Anderson CS et al. Lipid Paradox in Statin-Naive Acute Ischemic Stroke But Not Hemorrhagic Stroke. Frontiers in neurology 2018; 9:541. http://www.ncbi.nlm.nih.gov/pubmed/?term=30210423
  28. Agarwal D, Schmader KE, Kossenkov AV et al. Immune response to influenza vaccination in the elderly is altered by chronic medication use. Immunity & ageing : I & A 2018; 15:19. http://www.ncbi.nlm.nih.gov/pubmed/?term=30186359
  29. Leite GAA, de Barros JWF, Martins ADC, Jr. et al. Ascorbic acid supplementation ameliorates testicular hormonal signaling, sperm production and oxidative stress in male rats exposed to rosuvastatin during pre-puberty. Journal of applied toxicology : JAT 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30240002
  30. Braun LR, Feldpausch MN, Czerwonka N et al. Effects of Pitavastatin on Insulin Sensitivity and Liver Fat: A Randomized Clinical Trial. J Clin Endocrinol Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30239757
  31. Colussi G, Zuttion F, Bais B et al. Pre-Procedural Statin Use Is Associated with Improved Long-Term Survival and Reduced Major Cardiovascular Events in Patients Undergoing Carotid Artery Stenting: A Retrospective Study. Journal of clinical medicine 2018; 7. http://www.ncbi.nlm.nih.gov/pubmed/?term=30227674
  32. Huang TM, Wu VC, Lin YF et al. Effects of Statin Use in Advanced Chronic Kidney Disease Patients. Journal of clinical medicine 2018; 7. http://www.ncbi.nlm.nih.gov/pubmed/?term=30227675
  33. Jiao Y, Cai S, Lin J et al. Statin-naive anti-HMGCR antibody-mediated necrotizing myopathy in China. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30205933
  34. Davidson ER, Snider MJ, Bartsch K et al. Tolerance of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) Inhibitors in Patients With Self-Reported Statin Intolerance. Journal of pharmacy practice 2018:897190018799218. http://www.ncbi.nlm.nih.gov/pubmed/?term=30222031
  35. Mitchell D, Guertin JR, LeLorier J. Value of a Hypothetical Pharmacogenomic Test for the Diagnosis of Statin-Induced Myopathy in Patients at High Cardiovascular Risk. Molecular diagnosis & therapy 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30218425
  36. Nabih ES, El-Kharashi OA. Targeting HMGB1/TLR4 axis and miR-21 by rosuvastatin: role in alleviating cholestatic liver injury in a rat model of bile duct ligation. Naunyn-Schmiedeberg's archives of pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203151
  37. Taylor BA, Thompson PD. Statin-Associated Muscle Disease: Advances in Diagnosis and Management. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30251222
  38. Fathy S, Shahin MH, Langaee T et al. Pharmacogenetic and clinical predictors of response to clopidogrel plus aspirin after acute coronary syndrome in Egyptians. Pharmacogenetics and genomics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30188374
  39. Xiang Q, Chen SQ, Ma LY et al. Association between SLCO1B1 T521C polymorphism and risk of statin-induced myopathy: a meta-analysis. Pharmacogenomics J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30250148
  40. Brown AS, Watson KE. Statin Intolerance. Rev Cardiovasc Med 2018; 19:S9-s19. http://www.ncbi.nlm.nih.gov/pubmed/?term=30207553
  41. Woodcock J, Khan MA. FDA Analysis of Atorvastatin Products Refutes Report of Methyl Ester Impurities. Therapeutic innovation & regulatory science 2014; 48:554-556. http://www.ncbi.nlm.nih.gov/pubmed/?term=30231449
  42. Bolat MS, Bakirtas M, Firat F et al. The effect of atorvastatin on penile intracavernosal pressure and cavernosal morphology in normocholesterolemic rats. Turkish journal of urology 2018:1-6. http://www.ncbi.nlm.nih.gov/pubmed/?term=30183612
  43. Chiu HT, Shen LJ, Chen YC et al. Effect of statin use on the risk of medically attended acute respiratory illness among influenza vaccinated elderly. Vaccine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174239
  44. Texakalidis P, Giannopoulos S, Kokkinidis DG et al. In Reply to "Statin Use in Patients Undergoing Carotid Artery Endarterectomy May Significantly Reduce the Occurrence of 30-day Stroke and Myocardial Infarction". World neurosurgery 2018; 118:396. http://www.ncbi.nlm.nih.gov/pubmed/?term=30248820

Stroke and CNS

  1. Chung CM, Lin MS, Liu CH et al. Discontinuing or continuing statin following intracerebral hemorrhage from the view of a national cohort study. Atherosclerosis 2018; 278:15-22. http://www.ncbi.nlm.nih.gov/pubmed/?term=30236866
  2. Ziff OJ, Werring DJ. Statins after intracranial haemorrhage: seizing a new opportunity? Br J Clin Pharmacol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30192019
  3. Yao D, Jing T, Niu L et al. Amyloidogenesis Induced by Diet Cholesterol and Copper in a Model Mouse for Alzheimer's Disease and Protection Effects of Zinc and Fluvastatin. Brain research bulletin 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30227236
  4. Osawa K, Trejo MEP, Nakanishi R et al. Coronary artery calcium and carotid artery intima-media thickness for the prediction of stroke and benefit from statins. Eur J Prev Cardiol 2018:2047487318798058. http://www.ncbi.nlm.nih.gov/pubmed/?term=30183342
  5. Cheng KH, Lin JR, Anderson CS et al. Lipid Paradox in Statin-Naive Acute Ischemic Stroke But Not Hemorrhagic Stroke. Frontiers in neurology 2018; 9:541. http://www.ncbi.nlm.nih.gov/pubmed/?term=30210423
  6. Adeli S, Zahmatkesh M, Ansari Dezfouli M. Simvastatin Attenuates Hippocampal MMP-9 Expression in the Streptozotocin-Induced Cognitive Impairment. Iranian biomedical journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30218997
  7. Wu H, Lv W, Pan Q et al. Simvastatin therapy in adolescent mice attenuates HFD-induced depression-like behavior by reducing hippocampal neuroinflammation. Journal of affective disorders 2018; 243:83-95. http://www.ncbi.nlm.nih.gov/pubmed/?term=30236762
  8. Oh TK, Park HY, Shin HJ et al. The Role of Perioperative Statin Use in the Prevention of Delirium After Total Knee Replacement Under Spinal Anesthesia. The Journal of arthroplasty 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30236494
  9. Shakour N, Bianconi V, Pirro M et al. In silico evidence of direct interaction between statins and beta-amyloid. Journal of cellular biochemistry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30260016
  10. Zhao FL, Mi DH, Zhang CQ et al. A cohort study of isolated brainstem infarction based on head MR imaging and clinical findings. J Int Med Res 2018:300060518788253. http://www.ncbi.nlm.nih.gov/pubmed/?term=30246581
  11. Tang R, Shi J, Li X et al. Corrigendum to "Effects of Atorvastatin on Surgical Treatments of Chronic Subdural Hematoma" [World Neurosurgery 117 (2018) e425-e429]. World neurosurgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30213465
  12. Zheng F, Qiu C, Yang S, Krischek B. Statin Use in Patients Undergoing Carotid Artery Endarterectomy May Significantly Reduce the Occurrence of 30-Day Stroke and Myocardial Infarction. World neurosurgery 2018; 118:395. http://www.ncbi.nlm.nih.gov/pubmed/?term=30248819

Triglycerides/HDL

  1. Hernandez-Mijares A, Ascaso JF, Blasco M et al. Residual cardiovascular risk of lipid origin. Components and pathophysiological aspects. Clin Investig Arterioscler 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30262442
  2. Nichols GA, Philip S, Reynolds K et al. Increased Residual Cardiovascular Risk in Patients with Diabetes and High vs. Normal Triglycerides Despite Statin-Controlled LDL Cholesterol. Diabetes Obes Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30225881
  3. Cicero AFG, Fogacci F, Bove M et al. Optimizing Lipid Pattern by Adding a Combined Nutraceutical or Pravastatin to Fenofibrate Treatment in Hypertriglyceridemic Subjects: Single Site, Randomized, Open-Label, Post-Market Clinical Investigation. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30229462
  4. Lee D, Joo HJ, Jung HW, Lim DS. Investigating potential mediator between statin and coronary artery calcification. PLoS One 2018; 13:e0203702. http://www.ncbi.nlm.nih.gov/pubmed/?term=30226851

Trials

  1. Patyk I, Rybacki C, Kalicka A et al. Simvastatin Therapy and Bronchoalveolar Lavage Fluid Biomarkers in Chronic Obstructive Pulmonary Disease. Advances in experimental medicine and biology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30255302
  2. Ambrosy AP, Cerbin LP, Fudim M et al. Natural History of Patients Postacute Coronary Syndrome Based on Heart Failure Status. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30180960
  3. Choi JY, Choi CU, Hwang SY et al. Effect of Pitavastatin Compared with Atorvastatin and Rosuvastatin on New-Onset Diabetes Mellitus in Patients With Acute Myocardial Infarction. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30217375
  4. Jubran A, Zetser A, Zafrir B. Lipoprotein(a) screening in young and middle-aged patients presenting with acute coronary syndrome. Cardiology journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30234895
  5. Korpela T, Cardenas-Jaen K, Archibugi L et al. Chronic use of statins and risk of post-ERCP acute pancreatitis (STARK): Study protocol for an international multicenter prospective cohort study. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30224317
  6. Toribio M, Fitch KV, Stone L et al. Assessing statin effects on cardiovascular pathways in HIV using a novel proteomics approach: Analysis of data from INTREPID, a randomized controlled trial. EBioMedicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30174281
  7. Poh KK, Ambegaonkar B, Baxter CA et al. Low-density lipoprotein cholesterol target attainment in patients with stable or acute coronary heart disease in the Asia-Pacific region: results from the Dyslipidemia International Study II. Eur J Prev Cardiol 2018:2047487318798927. http://www.ncbi.nlm.nih.gov/pubmed/?term=30198749
  8. He W, Huang Y, Zhang Y et al. Cardiac rehabilitation therapy for coronary slow flow phenomenon. Herz 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30191265
  9. Orkaby AR, Rich MW, Sun R et al. Pravastatin for Primary Prevention in Older Adults: Restricted Mean Survival Time Analysis. J Am Geriatr Soc 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30251369
  10. Oh TK, Park HY, Shin HJ et al. The Role of Perioperative Statin Use in the Prevention of Delirium After Total Knee Replacement Under Spinal Anesthesia. The Journal of arthroplasty 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30236494
  11. Sakata K, Gamou T, Tada H et al. Low Baseline High-Sensitive C-Reactive Protein is Associated with Coronary Atherosclerosis Regression: Insights from the MILLION Study. J Atheroscler Thromb 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30249940
  12. Liu Q, Wang Y, Cheng X. The functional effect of atorvastatin dose-dependent via inflammation factors on acute ST segment elevation myocardial infarction after emergency percutaneous coronary intervention. Journal of cardiovascular medicine (Hagerstown, Md.) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30222665
  13. Braun LR, Feldpausch MN, Czerwonka N et al. Effects of Pitavastatin on Insulin Sensitivity and Liver Fat: A Randomized Clinical Trial. J Clin Endocrinol Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30239757
  14. Arian A, Mortazavi Moghadam SG, Kazemi T et al. Trial of Atorvastatin on Serum Interleukin-6, Total Antioxidant Capacity, C-Reactive Protein, and Alpha-1 Antitrypsin in Patients with Chronic Obstructive Pulmonary Disease. Journal of research in pharmacy practice 2018; 7:141-146. http://www.ncbi.nlm.nih.gov/pubmed/?term=30211239
  15. Lopes RD, de Barros ESPGM, de Andrade Jesuino I et al. Timing of Loading Dose of Atorvastatin in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes: Insights From the SECURE-PCI Randomized Clinical Trial. JAMA cardiology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30264159
  16. Khalil S, Bardawil T, Saade S et al. Use of Topical Glycolic Acid Plus a Lovastatin-Cholesterol Combination Cream for the Treatment of Autosomal Recessive Congenital Ichthyoses. JAMA dermatology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30208477
  17. Nam CW, Kim DS, Li J et al. Efficacy and safety of alirocumab in Korean patients with hypercholesterolemia and high cardiovascular risk: subanalysis of the ODYSSEY-KT study. The Korean journal of internal medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30257549
  18. Turk Veselic M, Erzen B, Hanzel J et al. Improving Arterial Wall Characteristics in Patients After Myocardial Infarction with a Very Low Dose of Fluvastatin and Valsartan: A Proof-of-Concept Study. Medical science monitor : international medical journal of experimental and clinical research 2018; 24:6892-6899. http://www.ncbi.nlm.nih.gov/pubmed/?term=30266894
  19. Idzerda NMA, Pena MJ, Parving HH et al. Proteinuria and cholesterol reduction are independently associated with less renal function decline in statin-treated patients; apost hoc analysis of the PLANET trials. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30184238
  20. Liu M, Liu G, Wang M. Comparison and analysis of the therapeutic effect of different statins in the treatment of atherosclerosis. Pak J Pharm Sci 2018; 31:1737-1742. http://www.ncbi.nlm.nih.gov/pubmed/?term=30203772
  21. Fathy S, Shahin MH, Langaee T et al. Pharmacogenetic and clinical predictors of response to clopidogrel plus aspirin after acute coronary syndrome in Egyptians. Pharmacogenetics and genomics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30188374
  22. Gitt AK, Rieber J, Hambrecht R et al. Do acute coronary events affect lipid management and cholesterol goal attainment in Germany? : Results from the Dyslipidemia International study II. Wien Klin Wochenschr 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30178071

Women and elderly

  1. Afrouzian M, Al-Lahham R, Patrikeeva S et al. Role of the Efflux Transporters BCRP and MRP1 in Human Placental Bio-disposition of Pravastatin. Biochem Pharmacol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30217571
  2. Ramos R, Comas-Cufi M, Marti-Lluch R et al. Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study. Bmj 2018; 362:k3359. http://www.ncbi.nlm.nih.gov/pubmed/?term=30185425
  3. Mintzer S, Trinka E, Kraemer G et al. Impact of carbamazepine, lamotrigine, and levetiracetam on vascular risk markers and lipid-lowering agents in the elderly. Epilepsia 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30178473
  4. Pelizzo G, Bussani R, Mazzon E et al. Effects of Simvastatin on Fetal Cardiac Impairment in the Diaphragmatic Experimental Hernia Model. Fetal diagnosis and therapy 2018:1-10. http://www.ncbi.nlm.nih.gov/pubmed/?term=30199868
  5. Agarwal D, Schmader KE, Kossenkov AV et al. Immune response to influenza vaccination in the elderly is altered by chronic medication use. Immunity & ageing : I & A 2018; 15:19. http://www.ncbi.nlm.nih.gov/pubmed/?term=30186359
  6. Orkaby AR, Rich MW, Sun R et al. Pravastatin for Primary Prevention in Older Adults: Restricted Mean Survival Time Analysis. J Am Geriatr Soc 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30251369

 
 
 


Twitter
IAS Website
For information
You are now on the editors mailing list of the IAS Statin Newsletter.
The IAS Statin Newsletter is part of the IAS News and Literature update service.
 
This activity is supported by an educational grant from Pfizer.