up-to-date with a click!
Update March, 2018
 
Curated by Peter Lansberg,
a Dutch lipidologist and educator, and
reviewed by prof. Philip Barter, Past President of the
International Atherosclerosis Society.

The IAS Statin Newsletter will keep you up-to-date with all recent statin publications, using a curated approach to select relevant articles.

Statin publications March 2018

Other

  1. Hodges GW, Bang CN, Forman JL et al. Effect of simvastatin and ezetimibe on suPAR levels and outcomes. Atherosclerosis 2018; 272:129-136. http://www.ncbi.nlm.nih.gov/pubmed/?term=29602140
  2. Khan S, Khan I, Novak M et al. The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis. Cureus 2018; 10:e2020. http://www.ncbi.nlm.nih.gov/pubmed/?term=29531873
  3. Elnaem MH, Nik Mohamed MH, Zaman Huri H, Azarisman SM. Impact of educational outreach intervention on enhancing health care providers' knowledge about statin therapy prescribing in Malaysian patients with type 2 diabetes mellitus. J Eval Clin Pract 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29508492
  4. Bruckert E, Gallo A. [Statin treatment must be personalized]. La Revue de medecine interne / fondee ... par la Societe nationale francaise de medecine interne 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29510859
  5. Bin Abdulhak AA, Vaughan-Sarrzin M, Kaboli P et al. Temporal Trends of High-Intensity Statin Therapy Among Veterans Treated With Percutaneous Coronary Intervention. J Am Heart Assoc 2018; 7. http://www.ncbi.nlm.nih.gov/pubmed/?term=29503265

Add on treatments

  1. Tacconelli S, Dovizio M, Di Francesco L et al. Reduced variability to aspirin antiplatelet effect by the coadministration of statins in high-risk patients for cardiovascular disease. Clinical pharmacology and therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574792
  2. Sundstrom J, Gulliksson G, Wiren M. Synergistic effects of blood pressure-lowering drugs and statins: systematic review and meta-analysis. BMJ evidence-based medicine 2018; 23:64-69. http://www.ncbi.nlm.nih.gov/pubmed/?term=29595132
  3. Hodges GW, Bang CN, Forman JL et al. Effect of simvastatin and ezetimibe on suPAR levels and outcomes. Atherosclerosis 2018; 272:129-136. http://www.ncbi.nlm.nih.gov/pubmed/?term=29602140
  4. Carris NW, Tsalatsanis A, Tipparaju SM et al. Metformin's Impact on Statin-Associated Muscle Symptoms: An analysis of ACCORD study data and research materials from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center. Diabetes Obes Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29577553
  5. Brinton EA, Ballantyne CM, Guyton JR et al. Lipid Effects of Icosapent Ethyl in Women with Diabetes Mellitus and Persistent High Triglycerides on Statin Treatment: ANCHOR Trial Subanalysis. Journal of women's health (2002) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29583081
  6. Lee HY, Jun DW, Kim HJ et al. Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis. The Korean journal of internal medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29551054
  7. Khan SU, Talluri S, Riaz H et al. A Bayesian network meta-analysis of PCSK9 inhibitors, statins and ezetimibe with or without statins for cardiovascular outcomes. Eur J Prev Cardiol 2018:2047487318766612. http://www.ncbi.nlm.nih.gov/pubmed/?term=29569492
  8. Dezsi CA. Treatment with triple combination of atorvastatin, perindopril, and amlodipine in patients with stable coronary artery disease: A subgroup analysis from the PAPA-CAD study. J Int Med Res 2018:300060518760158. http://www.ncbi.nlm.nih.gov/pubmed/?term=29557300
  9. Malik M, Tasnim N, Mahmud G. Effect of Metformin Alone Compared with Metformin Plus Simvastatin on Polycystic Ovarian Syndrome in Pakistani Women. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2018; 28:184-187. http://www.ncbi.nlm.nih.gov/pubmed/?term=29544572
  10. Kerr AJ, Turaga M, Grey C et al. Initiation and maintenance of statins and aspirin after acute coronary syndromes (ANZACS-QI 11). Journal of primary health care 2016; 8:238-249. http://www.ncbi.nlm.nih.gov/pubmed/?term=29530207
  11. Caltabiano S, Mahar KM, Lister K et al. The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects. Pharmacol Res Perspect 2018; 6:e00327. http://www.ncbi.nlm.nih.gov/pubmed/?term=29545948
  12. Xu D, Hu J, Wu Q et al. Efficacy and safety of Zhibitai in combination with atorvastatin for lipid lowering in patients with coronary heart disease. Oncotarget 2018; 9:9489-9497. http://www.ncbi.nlm.nih.gov/pubmed/?term=29507705
  13. Russell C, Sheth S, Jacoby D. A Clinical Guide to Combination Lipid-Lowering Therapy. Curr Atheroscler Rep 2018; 20:19. http://www.ncbi.nlm.nih.gov/pubmed/?term=29516190
  14. Demirci D, Ersan Demirci D. Lack of accurate evidence on non-statin medication in patients receiving highintensity statin therapy: Re-evaluation of recommendations is needed. Anatol J Cardiol 2018; 19:230. http://www.ncbi.nlm.nih.gov/pubmed/?term=29521324

Adherence

  1. Zhang H, Plutzky J, Ge W et al. Predictors of a successful statin reattempt after an adverse reaction. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29567104
  2. Navar AM, Peterson ED, Li S et al. Prevalence and Management of Symptoms Associated With Statin Therapy in Community Practice: Insights From the PALM (Patient and Provider Assessment of Lipid Management) Registry. Circ Cardiovasc Qual Outcomes 2018; 11:e004249. http://www.ncbi.nlm.nih.gov/pubmed/?term=29545393
  3. Kessler JB, Troxel AB, Asch DA et al. Partners and Alerts in Medication Adherence: A Randomized Clinical Trial. Journal of general internal medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29546659
  4. Kerr AJ, Turaga M, Grey C et al. Initiation and maintenance of statins and aspirin after acute coronary syndromes (ANZACS-QI 11). Journal of primary health care 2016; 8:238-249. http://www.ncbi.nlm.nih.gov/pubmed/?term=29530207
  5. Guerard B, Omachonu V, Perez B, Sen B. The Effectiveness of a Comprehensive Wellness Assessment on Medication Adherence in a Medicare Advantage Plan Diabetic Population. Journal of healthcare management / American College of Healthcare Executives 2018; 63:132-141. http://www.ncbi.nlm.nih.gov/pubmed/?term=29533324
  6. Nissen SE. Statin Denial: An Internet-Driven Cult With Deadly Consequences. Annals of internal medicine 2018; 168:381-382. http://www.ncbi.nlm.nih.gov/pubmed/?term=29507960
  7. Davis DS. Statin Denial: An Internet-Driven Cult With Deadly Consequences. Annals of internal medicine 2018; 168:382. http://www.ncbi.nlm.nih.gov/pubmed/?term=29507959
  8. Bamji A. Statin Denial: An Internet-Driven Cult With Deadly Consequences. Annals of internal medicine 2018; 168:381-382. http://www.ncbi.nlm.nih.gov/pubmed/?term=29507958

Atherosclerosis & Imaging

  1. Lichtenstein G, Perlman A, Shpitzen S et al. Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients. PLoS One 2018; 13:e0195061. http://www.ncbi.nlm.nih.gov/pubmed/?term=29590197
  2. Harris JR, Teuteberg JJ, Shullo MA. Optimal Low Density Lipoprotein Concentration in Cardiac Allograft Vasculopathy. Clinical transplantation 2018:e13248. http://www.ncbi.nlm.nih.gov/pubmed/?term=29603413
  3. Kowalska K, Habrowska-Gorczynska DE, Neumayer C et al. Lower levels of Caveolin-1 and higher levels of endothelial nitric oxide synthase are observed in abdominal aortic aneurysm patients treated with simvastatin. Acta biochimica Polonica 2018; 65:111-118. http://www.ncbi.nlm.nih.gov/pubmed/?term=29549671
  4. Zhou F, Tan Y, Chen XH et al. Atorvastatin improves plaque stability in diabetic atherosclerosis through the RAGE pathway. Eur Rev Med Pharmacol Sci 2018; 22:1142-1149. http://www.ncbi.nlm.nih.gov/pubmed/?term=29509268
  5. Mujaj B, Bos D, Selwaness M et al. Statin use is associated with carotid plaque composition: The Rotterdam Study. Int J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29519676
  6. Kim CH, Wang S, Park JB et al. Assessing Impact of High-Dose Pitavastatin on Carotid Artery Elasticity with Speckle-Tracking Strain Imaging. J Atheroscler Thromb 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29515050

Atorvastatin/Rosuvastatin

  1. Qi W, Cao D, Li Y et al. Atorvastatin ameliorates early brain injury through inhibition of apoptosis and ER stress in a rat model of subarachnoid hemorrhage. Bioscience reports 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29592873
  2. Peng J, Tian H, Du Q et al. A regenerable sorbent composed of a zeolite imidazolate framework (ZIF-8), Fe3O4 and graphene oxide for enrichment of atorvastatin and simvastatin prior to their determination by HPLC. Mikrochimica acta 2018; 185:141. http://www.ncbi.nlm.nih.gov/pubmed/?term=29594811
  3. Munkboel CH, Baake MLK, Styrishave B. Atorvastatin decreases steroid production in H295R cells and in major endocrine tissues of male rats. Archives of toxicology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574565
  4. Ades S, Douce D, Holmes CE et al. Effect of rosuvastatin on risk markers for venous thromboembolism in cancer. Journal of thrombosis and haemostasis : JTH 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29575637
  5. Yu Y, Jin L, Zhuang Y et al. Cardioprotective effect of rosuvastatin against isoproterenol-induced myocardial infarction injury in rats. International journal of molecular medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29568858
  6. Yang C, Zhao D, Liu G et al. Atorvastatin Attenuates Metabolic Remodeling in Ischemic Myocardium through the Downregulation of UCP2 Expression. International journal of medical sciences 2018; 15:517-527. http://www.ncbi.nlm.nih.gov/pubmed/?term=29559841
  7. Waters DD, Vogt L. Lipids, inflammation, and chronic kidney disease: a SHARP perspective. Kidney international 2018; 93:784-786. http://www.ncbi.nlm.nih.gov/pubmed/?term=29571452
  8. Melo AC, Cattani-Cavalieri I, Barroso MV et al. Atorvastatin dose-dependently promotes mouse lung repair after emphysema induced by elastase. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018; 102:160-168. http://www.ncbi.nlm.nih.gov/pubmed/?term=29554594
  9. Machairas G, Panderi I, Geballa-Koukoula A et al. Development and validation of a hydrophilic interaction liquid chromatography method for the quantitation of impurities in fixed-dose combination tablets containing rosuvastatin and metformin. Talanta 2018; 183:131-141. http://www.ncbi.nlm.nih.gov/pubmed/?term=29567155
  10. Dezsi CA. Treatment with triple combination of atorvastatin, perindopril, and amlodipine in patients with stable coronary artery disease: A subgroup analysis from the PAPA-CAD study. J Int Med Res 2018:300060518760158. http://www.ncbi.nlm.nih.gov/pubmed/?term=29557300
  11. Zahr RS, Chappa P, Yin H et al. Renal protection by atorvastatin in a murine model of sickle cell nephropathy. British journal of haematology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29527679
  12. Yasar M, Erdi I, Kaya B. The preventive effects of atorvastatin and N-acetyl cysteine in experimentally induced ischemia-reperfusion injury in rats. Bratislavske lekarske listy 2018; 119:167-174. http://www.ncbi.nlm.nih.gov/pubmed/?term=29536746
  13. Xiao YH, He XY, Han Q et al. Atorvastatin prevents glomerular extracellular matrix formation by interfering with the PKC signaling pathway. Mol Med Rep 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29532876
  14. Warraich HJ, Salami JA, Khera R et al. Trends in Use and Expenditures of Brand-name Atorvastatin After Introduction of Generic Atorvastatin. JAMA Intern Med 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525818
  15. Sheikh-Hasani V, Babaei M, Azadbakht A et al. Atorvastatin treatment softens human red blood cells: an optical tweezers study. Biomedical optics express 2018; 9:1256-1261. http://www.ncbi.nlm.nih.gov/pubmed/?term=29541518
  16. Oikawa T, Sakata Y, Nochioka K et al. Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study. J Am Heart Assoc 2018; 7. http://www.ncbi.nlm.nih.gov/pubmed/?term=29540427
  17. Nascimento RD, Guerra Jnr AA, Alvares J et al. Statin use in Brazil: findings and implications. Current medical research and opinion 2018:1-21. http://www.ncbi.nlm.nih.gov/pubmed/?term=29528246
  18. Liu Y, Yang H, Jia G et al. The Synergistic Neuroprotective Effects of Combined Rosuvastatin and Resveratrol Pretreatment against Cerebral Ischemia/Reperfusion Injury. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525080
  19. Liu LY, Liu Y, Wu MY et al. Efficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis. Drug design, development and therapy 2018; 12:437-444. http://www.ncbi.nlm.nih.gov/pubmed/?term=29535505
  20. Khan S, Khan I, Novak M et al. The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis. Cureus 2018; 10:e2020. http://www.ncbi.nlm.nih.gov/pubmed/?term=29531873
  21. Demir V, Dogru MT, Ede H et al. The effects of treatment with atorvastatin versus rosuvastatin on endothelial dysfunction in patients with hyperlipidaemia. Cardiovascular journal of Africa 2018; 29:1-5. http://www.ncbi.nlm.nih.gov/pubmed/?term=29528361
  22. Caltabiano S, Mahar KM, Lister K et al. The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects. Pharmacol Res Perspect 2018; 6:e00327. http://www.ncbi.nlm.nih.gov/pubmed/?term=29545948
  23. Berwanger O, Santucci EV, de Barros ESPGM et al. Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial. Jama 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525821
  24. Angelo ML, Moreira FL, Morais Ruela AL et al. Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review. Critical reviews in analytical chemistry 2018:1-13. http://www.ncbi.nlm.nih.gov/pubmed/?term=29533074
  25. Zhou F, Tan Y, Chen XH et al. Atorvastatin improves plaque stability in diabetic atherosclerosis through the RAGE pathway. Eur Rev Med Pharmacol Sci 2018; 22:1142-1149. http://www.ncbi.nlm.nih.gov/pubmed/?term=29509268
  26. Xu D, Hu J, Wu Q et al. Efficacy and safety of Zhibitai in combination with atorvastatin for lipid lowering in patients with coronary heart disease. Oncotarget 2018; 9:9489-9497. http://www.ncbi.nlm.nih.gov/pubmed/?term=29507705
  27. Wang H, Yin J, Guo Y. Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-kappaB signal pathway. Clinical and experimental hypertension (New York, N.Y. : 1993) 2018:1-4. http://www.ncbi.nlm.nih.gov/pubmed/?term=29509049
  28. Shen Z, Li S, Sheng B et al. The role of atorvastatin in suppressing tumor growth of uterine fibroids. Journal of translational medicine 2018; 16:53. http://www.ncbi.nlm.nih.gov/pubmed/?term=29523174

Basic science

  1. Qi W, Cao D, Li Y et al. Atorvastatin ameliorates early brain injury through inhibition of apoptosis and ER stress in a rat model of subarachnoid hemorrhage. Bioscience reports 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29592873
  2. Peng J, Tian H, Du Q et al. A regenerable sorbent composed of a zeolite imidazolate framework (ZIF-8), Fe3O4 and graphene oxide for enrichment of atorvastatin and simvastatin prior to their determination by HPLC. Mikrochimica acta 2018; 185:141. http://www.ncbi.nlm.nih.gov/pubmed/?term=29594811
  3. Munkboel CH, Baake MLK, Styrishave B. Atorvastatin decreases steroid production in H295R cells and in major endocrine tissues of male rats. Archives of toxicology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574565
  4. Ghalwash M, Elmasry A, El-Adeeb N. Effect of L-carnitine on the skeletal muscle contractility in simvastatin-induced myopathy in rats. Journal of basic and clinical physiology and pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29584613
  5. Cosar E, Mamillapalli R, Moridi I et al. Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of EMS. Reproductive sciences (Thousand Oaks, Calif.) 2018:1933719118765971. http://www.ncbi.nlm.nih.gov/pubmed/?term=29587611
  6. Yu Y, Jin L, Zhuang Y et al. Cardioprotective effect of rosuvastatin against isoproterenol-induced myocardial infarction injury in rats. International journal of molecular medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29568858
  7. Yang C, Zhao D, Liu G et al. Atorvastatin Attenuates Metabolic Remodeling in Ischemic Myocardium through the Downregulation of UCP2 Expression. International journal of medical sciences 2018; 15:517-527. http://www.ncbi.nlm.nih.gov/pubmed/?term=29559841
  8. Machairas G, Panderi I, Geballa-Koukoula A et al. Development and validation of a hydrophilic interaction liquid chromatography method for the quantitation of impurities in fixed-dose combination tablets containing rosuvastatin and metformin. Talanta 2018; 183:131-141. http://www.ncbi.nlm.nih.gov/pubmed/?term=29567155
  9. Lai SC, Phelps CA, Short AM et al. Thyroid transcription factor 1 enhances cellular statin sensitivity via perturbing cholesterol metabolism. Oncogene 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29551766
  10. Kowalska K, Habrowska-Gorczynska DE, Neumayer C et al. Lower levels of Caveolin-1 and higher levels of endothelial nitric oxide synthase are observed in abdominal aortic aneurysm patients treated with simvastatin. Acta biochimica Polonica 2018; 65:111-118. http://www.ncbi.nlm.nih.gov/pubmed/?term=29549671
  11. Kotyla PJ. Short course of simvastatin has no effect on markers of endothelial activation in normolipidemic patients with systemic sclerosis. J Int Med Res 2018:300060518762681. http://www.ncbi.nlm.nih.gov/pubmed/?term=29557229
  12. Ko HHT, Lareu RR, Dix BR, Hughes JD. In vitro antibacterial effects of statins against bacterial pathogens causing skin infections. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29569046
  13. Kassner F, Sauer T, Penke M et al. Simvastatin induces apoptosis in PTENhaploinsufficient lipoma cells. International journal of molecular medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29568880
  14. El-Abasawi NM, Attia KAM, Abo-Serie AAM et al. Simultaneous determination of rosuvastatin and propranolol in their binary mixture by synchronous spectrofluorimetry. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2018; 198:322-330. http://www.ncbi.nlm.nih.gov/pubmed/?term=29567601
  15. Yasar M, Erdi I, Kaya B. The preventive effects of atorvastatin and N-acetyl cysteine in experimentally induced ischemia-reperfusion injury in rats. Bratislavske lekarske listy 2018; 119:167-174. http://www.ncbi.nlm.nih.gov/pubmed/?term=29536746
  16. Xia K, Zhang P, Hu J et al. Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells. Oncology letters 2018; 15:4344-4350. http://www.ncbi.nlm.nih.gov/pubmed/?term=29541202
  17. Wang JC, Li XX, Sun X et al. Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF-1alpha-induced pro-angiogenic factor. Cancer science 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29532562
  18. Song H, Moon C, Lee BJ, Oh E. Mesoporous pravastatin solid dispersion granules incorporable into orally disintegrating tablets. Journal of pharmaceutical sciences 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29530714
  19. Sheikh-Hasani V, Babaei M, Azadbakht A et al. Atorvastatin treatment softens human red blood cells: an optical tweezers study. Biomedical optics express 2018; 9:1256-1261. http://www.ncbi.nlm.nih.gov/pubmed/?term=29541518
  20. Kany S, Woschek M, Kneip N et al. Simvastatin exerts anticancer effects in osteosarcoma cell lines via geranylgeranylation and c-Jun activation. International journal of oncology 2018; 52:1285-1294. http://www.ncbi.nlm.nih.gov/pubmed/?term=29532878
  21. Jeong C, Kim SE, Shim KS et al. Exploring the In Vivo Anti-Inflammatory Actions of Simvastatin-Loaded Porous Microspheres on Inflamed Tenocytes in a Collagenase-Induced Animal Model of Achilles Tendinitis. Int J Mol Sci 2018; 19. http://www.ncbi.nlm.nih.gov/pubmed/?term=29534523
  22. Cui X, Fu Z, Wang M et al. Pitavastatin treatment induces neuroprotection through the BDNF-TrkB signalling pathway in cultured cerebral neurons after oxygen-glucose deprivation. Neurol Res 2018:1-7. http://www.ncbi.nlm.nih.gov/pubmed/?term=29544396
  23. Caltabiano S, Mahar KM, Lister K et al. The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects. Pharmacol Res Perspect 2018; 6:e00327. http://www.ncbi.nlm.nih.gov/pubmed/?term=29545948
  24. Angelo ML, Moreira FL, Morais Ruela AL et al. Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review. Critical reviews in analytical chemistry 2018:1-13. http://www.ncbi.nlm.nih.gov/pubmed/?term=29533074
  25. Zhou F, Tan Y, Chen XH et al. Atorvastatin improves plaque stability in diabetic atherosclerosis through the RAGE pathway. Eur Rev Med Pharmacol Sci 2018; 22:1142-1149. http://www.ncbi.nlm.nih.gov/pubmed/?term=29509268
  26. Wang H, Yin J, Guo Y. Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-kappaB signal pathway. Clinical and experimental hypertension (New York, N.Y. : 1993) 2018:1-4. http://www.ncbi.nlm.nih.gov/pubmed/?term=29509049
  27. Wang CY, Shui HA, Chang TC. Dual effects for lovastatin in anaplastic thyroid cancer: the pivotal effect of transketolase (TKT) on lovastatin and tumor proliferation. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29502067
  28. Shen Z, Li S, Sheng B et al. The role of atorvastatin in suppressing tumor growth of uterine fibroids. Journal of translational medicine 2018; 16:53. http://www.ncbi.nlm.nih.gov/pubmed/?term=29523174
  29. Oi M, Donner D, Peart J et al. Pravastatin improves risk factors but not ischaemic tolerance in obese rats. Eur J Pharmacol 2018; 826:148-157. http://www.ncbi.nlm.nih.gov/pubmed/?term=29501869
  30. McFarland AJ, Davey AK, McDermott CM et al. Differences in statin associated neuroprotection corresponds with either decreased production of IL-1beta or TNF-alpha in an in vitro model of neuroinflammation-induced neurodegeneration. Toxicology and applied pharmacology 2018; 344:56-73. http://www.ncbi.nlm.nih.gov/pubmed/?term=29522792
  31. Hwang AR, Nam JO, Kang YJ. Fluvastatin inhibits advanced glycation end products-induced proliferation, migration, and extracellular matrix accumulation in vascular smooth muscle cells by targeting connective tissue growth factor. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2018; 22:193-201. http://www.ncbi.nlm.nih.gov/pubmed/?term=29520172

Cancer

  1. Iarrobino NA, Gill B, Bernard ME et al. Targeting Tumor Metabolism With Statins During Treatment for Advanced-stage Pancreatic Cancer. American journal of clinical oncology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29509593
  2. Wang JC, Li XX, Sun X et al. Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF-1alpha-induced pro-angiogenic factor. Cancer science 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29532562
  3. Ye X, Zhang G, Righolt C et al. Associations between Statin Use and Risk of Non-Hodgkin Lymphomas by Subtype. International journal of cancer. Journal international du cancer 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29524215
  4. Kany S, Woschek M, Kneip N et al. Simvastatin exerts anticancer effects in osteosarcoma cell lines via geranylgeranylation and c-Jun activation. International journal of oncology 2018; 52:1285-1294. http://www.ncbi.nlm.nih.gov/pubmed/?term=29532878
  5. Wang CY, Shui HA, Chang TC. Dual effects for lovastatin in anaplastic thyroid cancer: the pivotal effect of transketolase (TKT) on lovastatin and tumor proliferation. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29502067
  6. Ades S, Douce D, Holmes CE et al. Effect of rosuvastatin on risk markers for venous thromboembolism in cancer. Journal of thrombosis and haemostasis : JTH 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29575637
  7. Shen Z, Li S, Sheng B et al. The role of atorvastatin in suppressing tumor growth of uterine fibroids. Journal of translational medicine 2018; 16:53. http://www.ncbi.nlm.nih.gov/pubmed/?term=29523174
  8. Xia K, Zhang P, Hu J et al. Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells. Oncology letters 2018; 15:4344-4350. http://www.ncbi.nlm.nih.gov/pubmed/?term=29541202

Children

  1. Dai Y, Zhao X. Therapeutic effects of simvastatin combined with kallistatin treatment for pediatric burn patients with sepsis. Experimental and therapeutic medicine 2018; 15:3080-3087. http://www.ncbi.nlm.nih.gov/pubmed/?term=29599842

Cost-effectiveness

  1. Baum SJ, Cannon CP. PCSK9 inhibitor valuation: A science-based review of the two recent models. Clin Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512936

CVD

  1. Park JS, Cha KS, Lee HW et al. Predictive and protective role of high-density lipoprotein cholesterol in acute myocardial infarction. Cardiology journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512093
  2. Harris JR, Teuteberg JJ, Shullo MA. Optimal Low Density Lipoprotein Concentration in Cardiac Allograft Vasculopathy. Clinical transplantation 2018:e13248. http://www.ncbi.nlm.nih.gov/pubmed/?term=29603413
  3. Packer M. Are the effects of drugs to prevent and to treat heart failure always concordant? The statin paradox and its implications for understanding the actions of antidiabetic medications. European journal of heart failure 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29566300
  4. Sakai K, Koba S, Nakamura Y et al. Small dense low-density lipoprotein cholesterol is a promising biomarker for secondary prevention in older men with stable coronary artery disease. Geriatrics & gerontology international 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512264
  5. Oikawa T, Sakata Y, Nochioka K et al. Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study. J Am Heart Assoc 2018; 7. http://www.ncbi.nlm.nih.gov/pubmed/?term=29540427
  6. Han X, Zhang Y, Yin L et al. Statin in the treatment of patients with myocardial infarction: A meta-analysis. Medicine (Baltimore) 2018; 97:e0167. http://www.ncbi.nlm.nih.gov/pubmed/?term=29561426
  7. Lichtenstein G, Perlman A, Shpitzen S et al. Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients. PLoS One 2018; 13:e0195061. http://www.ncbi.nlm.nih.gov/pubmed/?term=29590197

Endothelium/inflammation

  1. Park JS, Cha KS, Lee HW et al. Predictive and protective role of high-density lipoprotein cholesterol in acute myocardial infarction. Cardiology journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512093
  2. Harris JR, Teuteberg JJ, Shullo MA. Optimal Low Density Lipoprotein Concentration in Cardiac Allograft Vasculopathy. Clinical transplantation 2018:e13248. http://www.ncbi.nlm.nih.gov/pubmed/?term=29603413
  3. Packer M. Are the effects of drugs to prevent and to treat heart failure always concordant? The statin paradox and its implications for understanding the actions of antidiabetic medications. European journal of heart failure 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29566300
  4. Sakai K, Koba S, Nakamura Y et al. Small dense low-density lipoprotein cholesterol is a promising biomarker for secondary prevention in older men with stable coronary artery disease. Geriatrics & gerontology international 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512264
  5. Oikawa T, Sakata Y, Nochioka K et al. Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study. J Am Heart Assoc 2018; 7. http://www.ncbi.nlm.nih.gov/pubmed/?term=29540427
  6. Han X, Zhang Y, Yin L et al. Statin in the treatment of patients with myocardial infarction: A meta-analysis. Medicine (Baltimore) 2018; 97:e0167. http://www.ncbi.nlm.nih.gov/pubmed/?term=29561426
  7. Lichtenstein G, Perlman A, Shpitzen S et al. Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients. PLoS One 2018; 13:e0195061. http://www.ncbi.nlm.nih.gov/pubmed/?term=29590197

Ethnicity

  1. Al-Rasadi K, Al-Zakwani I, Alsheikh-Ali AA et al. Prevalence, management, and outcomes of familial hypercholesterolemia in patients with acute coronary syndromes in the Arabian Gulf. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574074
  2. Kaewboonlert N, Thitisopee W, Sirintronsopon W et al. Lack of association between SLCO1B1 polymorphisms and lipid-lowering response to simvastatin therapy in Thai hypercholesterolaemic patients. Journal of clinical pharmacy and therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29575099

FH

  1. Al-Rasadi K, Al-Zakwani I, Alsheikh-Ali AA et al. Prevalence, management, and outcomes of familial hypercholesterolemia in patients with acute coronary syndromes in the Arabian Gulf. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574074
  2. Kaewboonlert N, Thitisopee W, Sirintronsopon W et al. Lack of association between SLCO1B1 polymorphisms and lipid-lowering response to simvastatin therapy in Thai hypercholesterolaemic patients. Journal of clinical pharmacy and therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29575099

Generics

  1. Warraich HJ, Salami JA, Khera R et al. Trends in Use and Expenditures of Brand-name Atorvastatin After Introduction of Generic Atorvastatin. JAMA Intern Med 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525818

Genetics

  1. Hindy G, Engstrom G, Larsson SC et al. Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study. Stroke 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29535274

Guidelines

  1. Levy ME, Greenberg AE, Magnus M et al. Evaluation of Statin Eligibility, Prescribing Practices, and Therapeutic Responses Using ATP III, ACC/AHA, and NLA Dyslipidemia Treatment Guidelines in a Large Urban Cohort of HIV-Infected Outpatients. AIDS patient care and STDs 2018; 32:58-69. http://www.ncbi.nlm.nih.gov/pubmed/?term=29561173
  2. Cesena FHY, Laurinavicius AG, Valente VA et al. Low-density lipoprotein-cholesterol lowering in individuals at intermediate cardiovascular risk: Percent reduction or target level? Clin Cardiol 2018; 41:333-338. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574925
  3. Schonmann Y, Bleich O, Matalon A, Yeshua H. Validation of the 2016 USPSTF recommendations for primary cardiovascular prevention in a large contemporary cohort. Eur J Prev Cardiol 2018:2047487318763825. http://www.ncbi.nlm.nih.gov/pubmed/?term=29517367
  4. Dopheide JF, Papac L, Schindewolf M et al. Poor attainment of lipid targets in patients with symptomatic peripheral artery disease. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574071
  5. Ueda P, Lung TW, Lu Y et al. Treatment gaps and potential cardiovascular risk reduction from expanded statin use in the US and England. PLoS One 2018; 13:e0190688. http://www.ncbi.nlm.nih.gov/pubmed/?term=29561843
  6. Asgari S, Abdi H, Hezaveh AM et al. The Burden of Statin Therapy based on ACC/AHA and NCEP ATP-III Guidelines: An Iranian Survey of Non-Communicable Diseases Risk Factors. Scientific reports 2018; 8:4928. http://www.ncbi.nlm.nih.gov/pubmed/?term=29563602
  7. Armstrong EJ, Waldo SW. Under-utilization of statin medications in patients with peripheral artery disease or cerebrovascular disease. Vascular medicine (London, England) 2018:1358863x18758915. http://www.ncbi.nlm.nih.gov/pubmed/?term=29600738

LDL- related parameters

  1. Breza J, Jr., Durackova Z, Payer J et al. Lipoprotein particle sizes in patients undergoing kidney transplantation. Bratislavske lekarske listy 2018; 119:130-132. http://www.ncbi.nlm.nih.gov/pubmed/?term=29536739
  2. Watts GF, Chan DC, Somaratne R et al. Controlled study of the effect of proprotein convertase subtilisin-kexin type 9 inhibition with evolocumab on lipoprotein(a) particle kinetics. Eur Heart J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29566128
  3. Sakai K, Koba S, Nakamura Y et al. Small dense low-density lipoprotein cholesterol is a promising biomarker for secondary prevention in older men with stable coronary artery disease. Geriatrics & gerontology international 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512264
  4. Chapman MJ, Orsoni A, Robillard P et al. Duality of statin action on lipoprotein subpopulations in the mixed dyslipidemia of metabolic syndrome: Quantity vs quality over time and implication of CETP. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574070
  5. Hindy G, Engstrom G, Larsson SC et al. Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study. Stroke 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29535274

Lifestyle

  1. Song KH, Kim YH, Im AR, Kim YH. Black Raspberry Extract Enhances LDL Uptake in HepG2 Cells by Suppressing PCSK9 Expression to Upregulate LDLR Expression. Journal of medicinal food 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29569973
  2. Scolaro B, Nogueira MS, Paiva A et al. Statin dose reduction with complementary diet therapy: A pilot study of personalized medicine. Molecular metabolism 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29503145

Meta-analyses

  1. Zaccardi F, Kunutsor SK, Seidu S et al. Is the lower risk of venous thromboembolism with statins related to low-density-lipoprotein reduction? A network meta-analysis and meta-regression of randomised controlled trials. Atherosclerosis 2018; 271:223-231. http://www.ncbi.nlm.nih.gov/pubmed/?term=29524865
  2. Sundstrom J, Gulliksson G, Wiren M. Synergistic effects of blood pressure-lowering drugs and statins: systematic review and meta-analysis. BMJ evidence-based medicine 2018; 23:64-69. http://www.ncbi.nlm.nih.gov/pubmed/?term=29595132
  3. Tariq R, Mukhija D, Gupta A et al. Statin use and the risk of Clostridium difficile infection: a systematic review with meta-analysis. Infection and drug resistance 2018; 11:405-416. http://www.ncbi.nlm.nih.gov/pubmed/?term=29559802
  4. Han X, Zhang Y, Yin L et al. Statin in the treatment of patients with myocardial infarction: A meta-analysis. Medicine (Baltimore) 2018; 97:e0167. http://www.ncbi.nlm.nih.gov/pubmed/?term=29561426
  5. Perng CH, Chang YC, Tzang RF. The treatment of cognitive dysfunction in dementia: a multiple treatments meta-analysis. Psychopharmacology (Berl) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29502274
  6. He SJ, Liu Q, Li HQ et al. Role of statins in preventing cardiac surgery-associated acute kidney injury: an updated meta-analysis of randomized controlled trials. Therapeutics and clinical risk management 2018; 14:475-482. http://www.ncbi.nlm.nih.gov/pubmed/?term=29551897
  7. Huang Q, Yang H, Lin Q et al. Effect of Statin Therapy on Survival After Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-analysis. World journal of surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29564515
  8. Wang ST, Sun XF. Role of Statins in Treatment and Prevention of Community-acquired Pneumonia:A Meta-analysis. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2018; 40:30-40. http://www.ncbi.nlm.nih.gov/pubmed/?term=29532779

Metabolic Syndrome - Diabetes

  1. Zaccardi F, Kunutsor SK, Seidu S et al. Is the lower risk of venous thromboembolism with statins related to low-density-lipoprotein reduction? A network meta-analysis and meta-regression of randomised controlled trials. Atherosclerosis 2018; 271:223-231. http://www.ncbi.nlm.nih.gov/pubmed/?term=29524865
  2. Sundstrom J, Gulliksson G, Wiren M. Synergistic effects of blood pressure-lowering drugs and statins: systematic review and meta-analysis. BMJ evidence-based medicine 2018; 23:64-69. http://www.ncbi.nlm.nih.gov/pubmed/?term=29595132
  3. Tariq R, Mukhija D, Gupta A et al. Statin use and the risk of Clostridium difficile infection: a systematic review with meta-analysis. Infection and drug resistance 2018; 11:405-416. http://www.ncbi.nlm.nih.gov/pubmed/?term=29559802
  4. Han X, Zhang Y, Yin L et al. Statin in the treatment of patients with myocardial infarction: A meta-analysis. Medicine (Baltimore) 2018; 97:e0167. http://www.ncbi.nlm.nih.gov/pubmed/?term=29561426
  5. Perng CH, Chang YC, Tzang RF. The treatment of cognitive dysfunction in dementia: a multiple treatments meta-analysis. Psychopharmacology (Berl) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29502274
  6. He SJ, Liu Q, Li HQ et al. Role of statins in preventing cardiac surgery-associated acute kidney injury: an updated meta-analysis of randomized controlled trials. Therapeutics and clinical risk management 2018; 14:475-482. http://www.ncbi.nlm.nih.gov/pubmed/?term=29551897
  7. Huang Q, Yang H, Lin Q et al. Effect of Statin Therapy on Survival After Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-analysis. World journal of surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29564515
  8. Wang ST, Sun XF. Role of Statins in Treatment and Prevention of Community-acquired Pneumonia:A Meta-analysis. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2018; 40:30-40. http://www.ncbi.nlm.nih.gov/pubmed/?term=29532779

New Treatments

  1. Karalis DG, Mallya UG, Ghannam AF et al. Prescribing Patterns of Proprotein Convertase Subtilisin-Kexin Type 9 Inhibitors in Eligible Patients With Clinical Atherosclerotic Cardiovascular Disease or Heterozygous Familial Hypercholesterolemia. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29548678
  2. Olkkonen VM, Sinisalo J, Jauhiainen M. New medications targeting triglyceride-rich lipoproteins: Can inhibition of ANGPTL3 or apoC-III reduce the residual cardiovascular risk? Atherosclerosis 2018; 272:27-32. http://www.ncbi.nlm.nih.gov/pubmed/?term=29544086
  3. Bohula EA, Giugliano RP, Leiter LA et al. Inflammatory and Cholesterol Risk in the FOURIER Trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Patients With Elevated Risk). Circulation 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29530884
  4. Baum SJ, Cannon CP. PCSK9 inhibitor valuation: A science-based review of the two recent models. Clin Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512936
  5. Wiggins BS, Senfield J, Kassahun H et al. Evolocumab: Considerations for the Management of Hyperlipidemia. Curr Atheroscler Rep 2018; 20:17. http://www.ncbi.nlm.nih.gov/pubmed/?term=29511875
  6. Ciccarelli G, D'Elia S, De Paulis M et al. Lipid Target in Very High-Risk Cardiovascular Patients: Lesson from PCSK9 Monoclonal Antibodies. Diseases (Basel, Switzerland) 2018; 6. http://www.ncbi.nlm.nih.gov/pubmed/?term=29562587
  7. Watts GF, Chan DC, Somaratne R et al. Controlled study of the effect of proprotein convertase subtilisin-kexin type 9 inhibition with evolocumab on lipoprotein(a) particle kinetics. Eur Heart J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29566128
  8. Khan SU, Talluri S, Riaz H et al. A Bayesian network meta-analysis of PCSK9 inhibitors, statins and ezetimibe with or without statins for cardiovascular outcomes. Eur J Prev Cardiol 2018:2047487318766612. http://www.ncbi.nlm.nih.gov/pubmed/?term=29569492
  9. Glueck CJ, Brown A, Goldberg AC et al. Alirocumab in high-risk patients: Observations from the open-label expanded use program. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525445
  10. Song KH, Kim YH, Im AR, Kim YH. Black Raspberry Extract Enhances LDL Uptake in HepG2 Cells by Suppressing PCSK9 Expression to Upregulate LDLR Expression. Journal of medicinal food 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29569973
  11. Willey J, Mentias A, Vaughan-Sarrazin M et al. Epidemiology of lower extremity peripheral artery disease in veterans. Journal of vascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29588132
  12. Toth PP, Dwyer JP, Cannon CP et al. Efficacy and safety of lipid lowering by alirocumab in chronic kidney disease. Kidney international 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29526502

PAD and statins

  1. Dopheide JF, Papac L, Schindewolf M et al. Poor attainment of lipid targets in patients with symptomatic peripheral artery disease. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574071
  2. Armstrong EJ, Waldo SW. Under-utilization of statin medications in patients with peripheral artery disease or cerebrovascular disease. Vascular medicine (London, England) 2018:1358863x18758915. http://www.ncbi.nlm.nih.gov/pubmed/?term=29600738
  3. McBride CL, Akeroyd JM, Ramsey DJ et al. Statin prescription rates and their facility-level variation in patients with peripheral artery disease and ischemic cerebrovascular disease: Insights from the Department of Veterans Affairs. Vascular medicine (London, England) 2018:1358863x18758914. http://www.ncbi.nlm.nih.gov/pubmed/?term=29600737

Pleiotropic effects of statins

  1. Chaffey P, Thompson M, Pai AD et al. Usefulness of Statins for Prevention of Venous Thromboembolism. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29576234
  2. Iarrobino NA, Gill B, Bernard ME et al. Targeting Tumor Metabolism With Statins During Treatment for Advanced-stage Pancreatic Cancer. American journal of clinical oncology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29509593
  3. Zaccardi F, Kunutsor SK, Seidu S et al. Is the lower risk of venous thromboembolism with statins related to low-density-lipoprotein reduction? A network meta-analysis and meta-regression of randomised controlled trials. Atherosclerosis 2018; 271:223-231. http://www.ncbi.nlm.nih.gov/pubmed/?term=29524865
  4. Melo AC, Cattani-Cavalieri I, Barroso MV et al. Atorvastatin dose-dependently promotes mouse lung repair after emphysema induced by elastase. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018; 102:160-168. http://www.ncbi.nlm.nih.gov/pubmed/?term=29554594
  5. Ryu JH, Park JW, Hwang JY et al. The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats. BMC anesthesiology 2018; 18:31. http://www.ncbi.nlm.nih.gov/pubmed/?term=29587636
  6. Sundstrom J, Gulliksson G, Wiren M. Synergistic effects of blood pressure-lowering drugs and statins: systematic review and meta-analysis. BMJ evidence-based medicine 2018; 23:64-69. http://www.ncbi.nlm.nih.gov/pubmed/?term=29595132
  7. Yasar M, Erdi I, Kaya B. The preventive effects of atorvastatin and N-acetyl cysteine in experimentally induced ischemia-reperfusion injury in rats. Bratislavske lekarske listy 2018; 119:167-174. http://www.ncbi.nlm.nih.gov/pubmed/?term=29536746
  8. Wang H, Yin J, Guo Y. Atorvastatin might resist tobacco smoking-induced endothelial inflammation through the inhibition of NF-kappaB signal pathway. Clinical and experimental hypertension (New York, N.Y. : 1993) 2018:1-4. http://www.ncbi.nlm.nih.gov/pubmed/?term=29509049
  9. Kotyla P. Low dose of simvastatin reduces disease activity and improves endothelial function in patients with SLE. Clinical and experimental rheumatology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29600937
  10. Sezavar M, Bohlouli B, Farhadi S et al. Simvastatin Effects on Dental Socket Quality: A Comparative Study. Contemporary clinical dentistry 2018; 9:55-59. http://www.ncbi.nlm.nih.gov/pubmed/?term=29599585
  11. Katsiki N, Triposkiadis F, Giannoukas AD, Mikhailidis DP. Statin loading in cardiovascular surgery: never too early to treat. Current opinion in cardiology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29601328
  12. Moctezuma-Velazquez C, Abraldes JG, Montano-Loza AJ. The Use of Statins in Patients With Chronic Liver Disease and Cirrhosis. Current treatment options in gastroenterology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29572618
  13. Ko HHT, Lareu RR, Dix BR, Hughes JD. In vitro antibacterial effects of statins against bacterial pathogens causing skin infections. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29569046
  14. Dai Y, Zhao X. Therapeutic effects of simvastatin combined with kallistatin treatment for pediatric burn patients with sepsis. Experimental and therapeutic medicine 2018; 15:3080-3087. http://www.ncbi.nlm.nih.gov/pubmed/?term=29599842
  15. Zeki AA, Elbadawi-Sidhu M. Innovations in asthma therapy: is there a role for inhaled statins? Expert review of respiratory medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29575963
  16. Tariq R, Mukhija D, Gupta A et al. Statin use and the risk of Clostridium difficile infection: a systematic review with meta-analysis. Infection and drug resistance 2018; 11:405-416. http://www.ncbi.nlm.nih.gov/pubmed/?term=29559802
  17. Antoniellis Silveira AA, Dominical VM, Morelli Vital D et al. Attenuation of TNF-induced neutrophil adhesion by simvastatin is associated with the inhibition of Rho-GTPase activity, p50 activity and morphological changes. Int Immunopharmacol 2018; 58:160-165. http://www.ncbi.nlm.nih.gov/pubmed/?term=29604489
  18. Ye X, Zhang G, Righolt C et al. Associations between Statin Use and Risk of Non-Hodgkin Lymphomas by Subtype. International journal of cancer. Journal international du cancer 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29524215
  19. Chapman MJ, Orsoni A, Robillard P et al. Duality of statin action on lipoprotein subpopulations in the mixed dyslipidemia of metabolic syndrome: Quantity vs quality over time and implication of CETP. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574070
  20. Gajzlerska-Majewska W, Bomba-Opon DA, Wielgos M. Is pravastatin a milestone in the prevention and treatment of preeclampsia? Journal of perinatal medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29570452
  21. Liu Y, Yang H, Jia G et al. The Synergistic Neuroprotective Effects of Combined Rosuvastatin and Resveratrol Pretreatment against Cerebral Ischemia/Reperfusion Injury. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525080
  22. Ades S, Douce D, Holmes CE et al. Effect of rosuvastatin on risk markers for venous thromboembolism in cancer. Journal of thrombosis and haemostasis : JTH 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29575637
  23. O'Donnell TFX, Deery SE, Shean KE et al. Statin therapy is associated with higher long-term but not perioperative survival after abdominal aortic aneurysm repair. Journal of vascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29580855
  24. Berwanger O, Santucci EV, de Barros ESPGM et al. Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial. Jama 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525821
  25. Lee HY, Jun DW, Kim HJ et al. Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis. The Korean journal of internal medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29551054
  26. Agus A, Phair G, Page VJ, McAuley DF. Simvastatin for the prevention and treatment of delirium in critically ill, mechanically ventilated patients (MoDUS): a cost-effectiveness analysis. The lancet. Respiratory medicine 2018; 6:e9-e10. http://www.ncbi.nlm.nih.gov/pubmed/?term=29508709
  27. Xiao YH, He XY, Han Q et al. Atorvastatin prevents glomerular extracellular matrix formation by interfering with the PKC signaling pathway. Mol Med Rep 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29532876
  28. Cui X, Fu Z, Wang M et al. Pitavastatin treatment induces neuroprotection through the BDNF-TrkB signalling pathway in cultured cerebral neurons after oxygen-glucose deprivation. Neurol Res 2018:1-7. http://www.ncbi.nlm.nih.gov/pubmed/?term=29544396
  29. Lee DS, Lee MY, Park CM et al. Preoperative statins are associated with a reduced risk of postoperative delirium following vascular surgery. PLoS One 2018; 13:e0192841. http://www.ncbi.nlm.nih.gov/pubmed/?term=29570715
  30. Kim DD, Barr AM, Thornton AE et al. Statin add-on therapy for schizophrenia: Is the effect the same for clozapine? Psychiatry research 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29566972
  31. He SJ, Liu Q, Li HQ et al. Role of statins in preventing cardiac surgery-associated acute kidney injury: an updated meta-analysis of randomized controlled trials. Therapeutics and clinical risk management 2018; 14:475-482. http://www.ncbi.nlm.nih.gov/pubmed/?term=29551897
  32. McFarland AJ, Davey AK, McDermott CM et al. Differences in statin associated neuroprotection corresponds with either decreased production of IL-1beta or TNF-alpha in an in vitro model of neuroinflammation-induced neurodegeneration. Toxicology and applied pharmacology 2018; 344:56-73. http://www.ncbi.nlm.nih.gov/pubmed/?term=29522792
  33. Huang Q, Yang H, Lin Q et al. Effect of Statin Therapy on Survival After Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-analysis. World journal of surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29564515
  34. Wang ST, Sun XF. Role of Statins in Treatment and Prevention of Community-acquired Pneumonia:A Meta-analysis. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2018; 40:30-40. http://www.ncbi.nlm.nih.gov/pubmed/?term=29532779

Primary Prevention

  1. Cesena FHY, Laurinavicius AG, Valente VA et al. Low-density lipoprotein-cholesterol lowering in individuals at intermediate cardiovascular risk: Percent reduction or target level? Clin Cardiol 2018; 41:333-338. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574925
  2. Schonmann Y, Bleich O, Matalon A, Yeshua H. Validation of the 2016 USPSTF recommendations for primary cardiovascular prevention in a large contemporary cohort. Eur J Prev Cardiol 2018:2047487318763825. http://www.ncbi.nlm.nih.gov/pubmed/?term=29517367

Registry data

  1. Silverman JM, Schmeidler J. Outcome age-based prediction of successful cognitive aging by total cholesterol. Alzheimer's & dementia : the journal of the Alzheimer's Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29514768
  2. Park JS, Cha KS, Lee HW et al. Predictive and protective role of high-density lipoprotein cholesterol in acute myocardial infarction. Cardiology journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512093
  3. Navar AM, Peterson ED, Li S et al. Prevalence and Management of Symptoms Associated With Statin Therapy in Community Practice: Insights From the PALM (Patient and Provider Assessment of Lipid Management) Registry. Circ Cardiovasc Qual Outcomes 2018; 11:e004249. http://www.ncbi.nlm.nih.gov/pubmed/?term=29545393
  4. Bucholz EM, Rodday AM, Kolor K et al. Prevalence and Predictors of Cholesterol Screening, Awareness, and Statin Treatment Among US Adults With Familial Hypercholesterolemia or Other Forms of Severe Dyslipidemia (1999-2014). Circulation 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29581125
  5. Harris JR, Teuteberg JJ, Shullo MA. Optimal Low Density Lipoprotein Concentration in Cardiac Allograft Vasculopathy. Clinical transplantation 2018:e13248. http://www.ncbi.nlm.nih.gov/pubmed/?term=29603413
  6. Nascimento RD, Guerra Jnr AA, Alvares J et al. Statin use in Brazil: findings and implications. Current medical research and opinion 2018:1-21. http://www.ncbi.nlm.nih.gov/pubmed/?term=29528246
  7. Saber-Ayad M, Manzoor S, El-Serafy A et al. Statin-induced myopathy SLCO1B1 521T>C is associated with Prediabetes, high Body mass index and normal lipid profile in Emirati Population. Diabetes Res Clin Pract 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29534995
  8. Ponziani MC, Karamouzis I, Mele C et al. Baseline glucose homeostasis predicts the new onset of diabetes during statin therapy: A retrospective study in real life. Hormones (Athens, Greece) 2017; 16:396-404. http://www.ncbi.nlm.nih.gov/pubmed/?term=29518760
  9. Ye X, Zhang G, Righolt C et al. Associations between Statin Use and Risk of Non-Hodgkin Lymphomas by Subtype. International journal of cancer. Journal international du cancer 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29524215
  10. Mujaj B, Bos D, Selwaness M et al. Statin use is associated with carotid plaque composition: The Rotterdam Study. Int J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29519676
  11. Oikawa T, Sakata Y, Nochioka K et al. Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study. J Am Heart Assoc 2018; 7. http://www.ncbi.nlm.nih.gov/pubmed/?term=29540427
  12. Kerr AJ, Turaga M, Grey C et al. Initiation and maintenance of statins and aspirin after acute coronary syndromes (ANZACS-QI 11). Journal of primary health care 2016; 8:238-249. http://www.ncbi.nlm.nih.gov/pubmed/?term=29530207
  13. Ruan XC, Low LL, Kwan YH. Association of aspartate aminotransferase in statin-induced rhabdomyolysis. Journal of primary health care 2017; 9:316-320. http://www.ncbi.nlm.nih.gov/pubmed/?term=29530144
  14. O'Donnell TFX, Deery SE, Shean KE et al. Statin therapy is associated with higher long-term but not perioperative survival after abdominal aortic aneurysm repair. Journal of vascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29580855
  15. Mark L, Nagy M, Dani G et al. [Lipid-lowering therapy of patients suffering from acute coronary syndrome in a Hungarian county hospital in 2015]. Orvosi hetilap 2018; 159:478-484. http://www.ncbi.nlm.nih.gov/pubmed/?term=29552926
  16. Lee DS, Lee MY, Park CM et al. Preoperative statins are associated with a reduced risk of postoperative delirium following vascular surgery. PLoS One 2018; 13:e0192841. http://www.ncbi.nlm.nih.gov/pubmed/?term=29570715
  17. Hindy G, Engstrom G, Larsson SC et al. Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study. Stroke 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29535274
  18. Sarfo FS, Sarfo-Kantanka O, Adamu S et al. Stroke Minimization through Additive Anti-atherosclerotic Agents in Routine Treatment (SMAART): study protocol for a randomized controlled trial. Trials 2018; 19:181. http://www.ncbi.nlm.nih.gov/pubmed/?term=29540234
  19. McBride CL, Akeroyd JM, Ramsey DJ et al. Statin prescription rates and their facility-level variation in patients with peripheral artery disease and ischemic cerebrovascular disease: Insights from the Department of Veterans Affairs. Vascular medicine (London, England) 2018:1358863x18758914. http://www.ncbi.nlm.nih.gov/pubmed/?term=29600737

Renal Disease

  1. Zahr RS, Chappa P, Yin H et al. Renal protection by atorvastatin in a murine model of sickle cell nephropathy. British journal of haematology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29527679
  2. Breza J, Jr., Durackova Z, Payer J et al. Lipoprotein particle sizes in patients undergoing kidney transplantation. Bratislavske lekarske listy 2018; 119:130-132. http://www.ncbi.nlm.nih.gov/pubmed/?term=29536739
  3. Licata A, Giammanco A, Minissale MG et al. Liver and statins: a critical appraisal of the evidence. Curr Med Chem 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29589533
  4. Liu LY, Liu Y, Wu MY et al. Efficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis. Drug design, development and therapy 2018; 12:437-444. http://www.ncbi.nlm.nih.gov/pubmed/?term=29535505
  5. Toth PP, Dwyer JP, Cannon CP et al. Efficacy and safety of lipid lowering by alirocumab in chronic kidney disease. Kidney international 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29526502
  6. Waters DD, Vogt L. Lipids, inflammation, and chronic kidney disease: a SHARP perspective. Kidney international 2018; 93:784-786. http://www.ncbi.nlm.nih.gov/pubmed/?term=29571452
  7. Xiao YH, He XY, Han Q et al. Atorvastatin prevents glomerular extracellular matrix formation by interfering with the PKC signaling pathway. Mol Med Rep 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29532876

Reviews

  1. Chaffey P, Thompson M, Pai AD et al. Usefulness of Statins for Prevention of Venous Thromboembolism. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29576234
  2. Demirci D, Ersan Demirci D. Lack of accurate evidence on non-statin medication in patients receiving highintensity statin therapy: Re-evaluation of recommendations is needed. Anatol J Cardiol 2018; 19:230. http://www.ncbi.nlm.nih.gov/pubmed/?term=29521324
  3. Zahr RS, Chappa P, Yin H et al. Renal protection by atorvastatin in a murine model of sickle cell nephropathy. British journal of haematology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29527679
  4. Cho KI, Sakuma I, Sohn IS et al. Best Treatment Strategies With Statins to Maximize the Cardiometabolic Benefits. Circulation journal : official journal of the Japanese Circulation Society 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29503409
  5. Baum SJ, Cannon CP. PCSK9 inhibitor valuation: A science-based review of the two recent models. Clin Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512936
  6. Adams SP, Sekhon SS, Tsang M, Wright JM. Fluvastatin for lowering lipids. The Cochrane database of systematic reviews 2018; 3:Cd012282. http://www.ncbi.nlm.nih.gov/pubmed/?term=29508377
  7. Sezavar M, Bohlouli B, Farhadi S et al. Simvastatin Effects on Dental Socket Quality: A Comparative Study. Contemporary clinical dentistry 2018; 9:55-59. http://www.ncbi.nlm.nih.gov/pubmed/?term=29599585
  8. Russell C, Sheth S, Jacoby D. A Clinical Guide to Combination Lipid-Lowering Therapy. Curr Atheroscler Rep 2018; 20:19. http://www.ncbi.nlm.nih.gov/pubmed/?term=29516190
  9. Wiggins BS, Senfield J, Kassahun H et al. Evolocumab: Considerations for the Management of Hyperlipidemia. Curr Atheroscler Rep 2018; 20:17. http://www.ncbi.nlm.nih.gov/pubmed/?term=29511875
  10. Licata A, Giammanco A, Minissale MG et al. Liver and statins: a critical appraisal of the evidence. Curr Med Chem 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29589533
  11. Katsiki N, Triposkiadis F, Giannoukas AD, Mikhailidis DP. Statin loading in cardiovascular surgery: never too early to treat. Current opinion in cardiology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29601328
  12. Pinal-Fernandez I, Casal-Dominguez M, Mammen AL. Immune-Mediated Necrotizing Myopathy. Curr Rheumatol Rep 2018; 20:21. http://www.ncbi.nlm.nih.gov/pubmed/?term=29582188
  13. Moctezuma-Velazquez C, Abraldes JG, Montano-Loza AJ. The Use of Statins in Patients With Chronic Liver Disease and Cirrhosis. Current treatment options in gastroenterology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29572618
  14. Ciccarelli G, D'Elia S, De Paulis M et al. Lipid Target in Very High-Risk Cardiovascular Patients: Lesson from PCSK9 Monoclonal Antibodies. Diseases (Basel, Switzerland) 2018; 6. http://www.ncbi.nlm.nih.gov/pubmed/?term=29562587
  15. Liu LY, Liu Y, Wu MY et al. Efficacy of atorvastatin on the prevention of contrast-induced acute kidney injury: a meta-analysis. Drug design, development and therapy 2018; 12:437-444. http://www.ncbi.nlm.nih.gov/pubmed/?term=29535505
  16. Packer M. Are the effects of drugs to prevent and to treat heart failure always concordant? The statin paradox and its implications for understanding the actions of antidiabetic medications. European journal of heart failure 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29566300
  17. Zeki AA, Elbadawi-Sidhu M. Innovations in asthma therapy: is there a role for inhaled statins? Expert review of respiratory medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29575963
  18. Ahmadi Y, Ghorbanihaghjo A, Naghi-Zadeh M, Yagin NL. Oxidative stress as a possible mechanism of statin-induced myopathy. Inflammopharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574631
  19. Gajzlerska-Majewska W, Bomba-Opon DA, Wielgos M. Is pravastatin a milestone in the prevention and treatment of preeclampsia? Journal of perinatal medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29570452
  20. Willey J, Mentias A, Vaughan-Sarrazin M et al. Epidemiology of lower extremity peripheral artery disease in veterans. Journal of vascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29588132
  21. Li HH, Lin CL, Huang CN. Neuroprotective effects of statins against amyloid beta-induced neurotoxicity. Neural regeneration research 2018; 13:198-206. http://www.ncbi.nlm.nih.gov/pubmed/?term=29557360
  22. Schultz BG, Patten DK, Berlau DJ. The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms. Translational neurodegeneration 2018; 7:5. http://www.ncbi.nlm.nih.gov/pubmed/?term=29507718

Safety and side effects

  1. Park IS, Lee SB, Song SH et al. Ticagrelor-induced acute kidney injury can increase serum concentration of statin and lead to concurrence of rhabdomyolysis. Anatol J Cardiol 2018; 19:225-226. http://www.ncbi.nlm.nih.gov/pubmed/?term=29521318
  2. Keihani S, Martin C, Craig JR et al. Semen parameters are unaffected by statin use in men evaluated for infertility. Andrologia 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512172
  3. Munkboel CH, Baake MLK, Styrishave B. Atorvastatin decreases steroid production in H295R cells and in major endocrine tissues of male rats. Archives of toxicology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574565
  4. Korhonen MJ, Tiittanen P, Kastarinen H et al. Statins do not Increase the Rate of Bleeding among Warfarin Users. Basic & clinical pharmacology & toxicology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29504234
  5. Tacconelli S, Dovizio M, Di Francesco L et al. Reduced variability to aspirin antiplatelet effect by the coadministration of statins in high-risk patients for cardiovascular disease. Clinical pharmacology and therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574792
  6. Khan S, Khan I, Novak M et al. The Concomitant Use of Atorvastatin and Amlodipine Leading to Rhabdomyolysis. Cureus 2018; 10:e2020. http://www.ncbi.nlm.nih.gov/pubmed/?term=29531873
  7. Pinal-Fernandez I, Casal-Dominguez M, Mammen AL. Immune-Mediated Necrotizing Myopathy. Curr Rheumatol Rep 2018; 20:21. http://www.ncbi.nlm.nih.gov/pubmed/?term=29582188
  8. Moctezuma-Velazquez C, Abraldes JG, Montano-Loza AJ. The Use of Statins in Patients With Chronic Liver Disease and Cirrhosis. Current treatment options in gastroenterology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29572618
  9. Carris NW, Tsalatsanis A, Tipparaju SM et al. Metformin's Impact on Statin-Associated Muscle Symptoms: An analysis of ACCORD study data and research materials from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center. Diabetes Obes Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29577553
  10. Saber-Ayad M, Manzoor S, El-Serafy A et al. Statin-induced myopathy SLCO1B1 521T>C is associated with Prediabetes, high Body mass index and normal lipid profile in Emirati Population. Diabetes Res Clin Pract 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29534995
  11. Erdur H, Polymeris A, Grittner U et al. A Score for Risk of Thrombolysis-Associated Hemorrhage Including Pretreatment with Statins. Frontiers in neurology 2018; 9:74. http://www.ncbi.nlm.nih.gov/pubmed/?term=29503629
  12. Ponziani MC, Karamouzis I, Mele C et al. Baseline glucose homeostasis predicts the new onset of diabetes during statin therapy: A retrospective study in real life. Hormones (Athens, Greece) 2017; 16:396-404. http://www.ncbi.nlm.nih.gov/pubmed/?term=29518760
  13. Ahmadi Y, Ghorbanihaghjo A, Naghi-Zadeh M, Yagin NL. Oxidative stress as a possible mechanism of statin-induced myopathy. Inflammopharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574631
  14. Ghalwash M, Elmasry A, El-Adeeb N. Effect of L-carnitine on the skeletal muscle contractility in simvastatin-induced myopathy in rats. Journal of basic and clinical physiology and pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29584613
  15. Kaewboonlert N, Thitisopee W, Sirintronsopon W et al. Lack of association between SLCO1B1 polymorphisms and lipid-lowering response to simvastatin therapy in Thai hypercholesterolaemic patients. Journal of clinical pharmacy and therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29575099
  16. Fralick M, Avorn J, Franklin JM et al. Application and Impact of Run-In Studies for the Evaluation of Statin Efficacy and Safety. Journal of general internal medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29520746
  17. Ruan XC, Low LL, Kwan YH. Association of aspartate aminotransferase in statin-induced rhabdomyolysis. Journal of primary health care 2017; 9:316-320. http://www.ncbi.nlm.nih.gov/pubmed/?term=29530144
  18. Ezad S, Cheema H, Collins N. Statin-induced rhabdomyolysis: a complication of a commonly overlooked drug interaction. Oxford medical case reports 2018; 2018:omx104. http://www.ncbi.nlm.nih.gov/pubmed/?term=29593874
  19. Caltabiano S, Mahar KM, Lister K et al. The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects. Pharmacol Res Perspect 2018; 6:e00327. http://www.ncbi.nlm.nih.gov/pubmed/?term=29545948
  20. He SJ, Liu Q, Li HQ et al. Role of statins in preventing cardiac surgery-associated acute kidney injury: an updated meta-analysis of randomized controlled trials. Therapeutics and clinical risk management 2018; 14:475-482. http://www.ncbi.nlm.nih.gov/pubmed/?term=29551897
  21. Schultz BG, Patten DK, Berlau DJ. The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms. Translational neurodegeneration 2018; 7:5. http://www.ncbi.nlm.nih.gov/pubmed/?term=29507718

Stroke and CNS

  1. Silverman JM, Schmeidler J. Outcome age-based prediction of successful cognitive aging by total cholesterol. Alzheimer's & dementia : the journal of the Alzheimer's Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29514768
  2. Qi W, Cao D, Li Y et al. Atorvastatin ameliorates early brain injury through inhibition of apoptosis and ER stress in a rat model of subarachnoid hemorrhage. Bioscience reports 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29592873
  3. Ryu JH, Park JW, Hwang JY et al. The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats. BMC anesthesiology 2018; 18:31. http://www.ncbi.nlm.nih.gov/pubmed/?term=29587636
  4. Erdur H, Polymeris A, Grittner U et al. A Score for Risk of Thrombolysis-Associated Hemorrhage Including Pretreatment with Statins. Frontiers in neurology 2018; 9:74. http://www.ncbi.nlm.nih.gov/pubmed/?term=29503629
  5. Mujaj B, Bos D, Selwaness M et al. Statin use is associated with carotid plaque composition: The Rotterdam Study. Int J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29519676
  6. Khokhar B, Simoni-Wastila L, Slejko JF et al. Patterns of Statin Use in Older Medicare Beneficiaries With Traumatic Brain Injury. The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians 2017; 33:156-166. http://www.ncbi.nlm.nih.gov/pubmed/?term=29577114
  7. Liu Y, Yang H, Jia G et al. The Synergistic Neuroprotective Effects of Combined Rosuvastatin and Resveratrol Pretreatment against Cerebral Ischemia/Reperfusion Injury. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525080
  8. Li HH, Lin CL, Huang CN. Neuroprotective effects of statins against amyloid beta-induced neurotoxicity. Neural regeneration research 2018; 13:198-206. http://www.ncbi.nlm.nih.gov/pubmed/?term=29557360
  9. Cui X, Fu Z, Wang M et al. Pitavastatin treatment induces neuroprotection through the BDNF-TrkB signalling pathway in cultured cerebral neurons after oxygen-glucose deprivation. Neurol Res 2018:1-7. http://www.ncbi.nlm.nih.gov/pubmed/?term=29544396
  10. Kim DD, Barr AM, Thornton AE et al. Statin add-on therapy for schizophrenia: Is the effect the same for clozapine? Psychiatry research 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29566972
  11. Perng CH, Chang YC, Tzang RF. The treatment of cognitive dysfunction in dementia: a multiple treatments meta-analysis. Psychopharmacology (Berl) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29502274
  12. Hindy G, Engstrom G, Larsson SC et al. Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study. Stroke 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29535274
  13. Hosomi N, Kitagawa K, Nagai Y et al. Desirable Low-Density Lipoprotein Cholesterol Levels for Preventing Stroke Recurrence: A Post Hoc Analysis of J-STARS Study (Japan Statin Treatment Against Recurrent Stroke). Stroke 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29511130
  14. McFarland AJ, Davey AK, McDermott CM et al. Differences in statin associated neuroprotection corresponds with either decreased production of IL-1beta or TNF-alpha in an in vitro model of neuroinflammation-induced neurodegeneration. Toxicology and applied pharmacology 2018; 344:56-73. http://www.ncbi.nlm.nih.gov/pubmed/?term=29522792
  15. Schultz BG, Patten DK, Berlau DJ. The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms. Translational neurodegeneration 2018; 7:5. http://www.ncbi.nlm.nih.gov/pubmed/?term=29507718
  16. Sarfo FS, Sarfo-Kantanka O, Adamu S et al. Stroke Minimization through Additive Anti-atherosclerotic Agents in Routine Treatment (SMAART): study protocol for a randomized controlled trial. Trials 2018; 19:181. http://www.ncbi.nlm.nih.gov/pubmed/?term=29540234
  17. Armstrong EJ, Waldo SW. Under-utilization of statin medications in patients with peripheral artery disease or cerebrovascular disease. Vascular medicine (London, England) 2018:1358863x18758915. http://www.ncbi.nlm.nih.gov/pubmed/?term=29600738
  18. McBride CL, Akeroyd JM, Ramsey DJ et al. Statin prescription rates and their facility-level variation in patients with peripheral artery disease and ischemic cerebrovascular disease: Insights from the Department of Veterans Affairs. Vascular medicine (London, England) 2018:1358863x18758914. http://www.ncbi.nlm.nih.gov/pubmed/?term=29600737

Triglycerides/HDL

  1. Olkkonen VM, Sinisalo J, Jauhiainen M. New medications targeting triglyceride-rich lipoproteins: Can inhibition of ANGPTL3 or apoC-III reduce the residual cardiovascular risk? Atherosclerosis 2018; 272:27-32. http://www.ncbi.nlm.nih.gov/pubmed/?term=29544086
  2. Park JS, Cha KS, Lee HW et al. Predictive and protective role of high-density lipoprotein cholesterol in acute myocardial infarction. Cardiology journal 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512093
  3. Cho KI, Sakuma I, Sohn IS et al. Best Treatment Strategies With Statins to Maximize the Cardiometabolic Benefits. Circulation journal : official journal of the Japanese Circulation Society 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29503409
  4. Chapman MJ, Orsoni A, Robillard P et al. Duality of statin action on lipoprotein subpopulations in the mixed dyslipidemia of metabolic syndrome: Quantity vs quality over time and implication of CETP. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574070
  5. Sahebkar A, Simental-Mendia LE, Mikhailidis DP et al. Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29580713
  6. Brinton EA, Ballantyne CM, Guyton JR et al. Lipid Effects of Icosapent Ethyl in Women with Diabetes Mellitus and Persistent High Triglycerides on Statin Treatment: ANCHOR Trial Subanalysis. Journal of women's health (2002) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29583081

Trials

  1. Kowalska K, Habrowska-Gorczynska DE, Neumayer C et al. Lower levels of Caveolin-1 and higher levels of endothelial nitric oxide synthase are observed in abdominal aortic aneurysm patients treated with simvastatin. Acta biochimica Polonica 2018; 65:111-118. http://www.ncbi.nlm.nih.gov/pubmed/?term=29549671
  2. Hodges GW, Bang CN, Forman JL et al. Effect of simvastatin and ezetimibe on suPAR levels and outcomes. Atherosclerosis 2018; 272:129-136. http://www.ncbi.nlm.nih.gov/pubmed/?term=29602140
  3. Demir V, Dogru MT, Ede H et al. The effects of treatment with atorvastatin versus rosuvastatin on endothelial dysfunction in patients with hyperlipidaemia. Cardiovascular journal of Africa 2018; 29:1-5. http://www.ncbi.nlm.nih.gov/pubmed/?term=29528361
  4. Bohula EA, Giugliano RP, Leiter LA et al. Inflammatory and Cholesterol Risk in the FOURIER Trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Patients With Elevated Risk). Circulation 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29530884
  5. Watts GF, Chan DC, Somaratne R et al. Controlled study of the effect of proprotein convertase subtilisin-kexin type 9 inhibition with evolocumab on lipoprotein(a) particle kinetics. Eur Heart J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29566128
  6. Sakai K, Koba S, Nakamura Y et al. Small dense low-density lipoprotein cholesterol is a promising biomarker for secondary prevention in older men with stable coronary artery disease. Geriatrics & gerontology international 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29512264
  7. Miyauchi K, Kimura T, Shimokawa H et al. Rationale and Design of Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy with Pitavastatin in Coronary Artery Disease (REAL-CAD) Trial. Int Heart J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29503404
  8. Kim CH, Wang S, Park JB et al. Assessing Impact of High-Dose Pitavastatin on Carotid Artery Elasticity with Speckle-Tracking Strain Imaging. J Atheroscler Thromb 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29515050
  9. Chapman MJ, Orsoni A, Robillard P et al. Duality of statin action on lipoprotein subpopulations in the mixed dyslipidemia of metabolic syndrome: Quantity vs quality over time and implication of CETP. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574070
  10. Glueck CJ, Brown A, Goldberg AC et al. Alirocumab in high-risk patients: Observations from the open-label expanded use program. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525445
  11. Kaewboonlert N, Thitisopee W, Sirintronsopon W et al. Lack of association between SLCO1B1 polymorphisms and lipid-lowering response to simvastatin therapy in Thai hypercholesterolaemic patients. Journal of clinical pharmacy and therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29575099
  12. Malik M, Tasnim N, Mahmud G. Effect of Metformin Alone Compared with Metformin Plus Simvastatin on Polycystic Ovarian Syndrome in Pakistani Women. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2018; 28:184-187. http://www.ncbi.nlm.nih.gov/pubmed/?term=29544572
  13. Kessler JB, Troxel AB, Asch DA et al. Partners and Alerts in Medication Adherence: A Randomized Clinical Trial. Journal of general internal medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29546659
  14. Dezsi CA. Treatment with triple combination of atorvastatin, perindopril, and amlodipine in patients with stable coronary artery disease: A subgroup analysis from the PAPA-CAD study. J Int Med Res 2018:300060518760158. http://www.ncbi.nlm.nih.gov/pubmed/?term=29557300
  15. Liu Y, Yang H, Jia G et al. The Synergistic Neuroprotective Effects of Combined Rosuvastatin and Resveratrol Pretreatment against Cerebral Ischemia/Reperfusion Injury. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525080
  16. Ades S, Douce D, Holmes CE et al. Effect of rosuvastatin on risk markers for venous thromboembolism in cancer. Journal of thrombosis and haemostasis : JTH 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29575637
  17. Brinton EA, Ballantyne CM, Guyton JR et al. Lipid Effects of Icosapent Ethyl in Women with Diabetes Mellitus and Persistent High Triglycerides on Statin Treatment: ANCHOR Trial Subanalysis. Journal of women's health (2002) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29583081
  18. Berwanger O, Santucci EV, de Barros ESPGM et al. Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial. Jama 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29525821
  19. Waters DD, Vogt L. Lipids, inflammation, and chronic kidney disease: a SHARP perspective. Kidney international 2018; 93:784-786. http://www.ncbi.nlm.nih.gov/pubmed/?term=29571452
  20. Scolaro B, Nogueira MS, Paiva A et al. Statin dose reduction with complementary diet therapy: A pilot study of personalized medicine. Molecular metabolism 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29503145
  21. Xu D, Hu J, Wu Q et al. Efficacy and safety of Zhibitai in combination with atorvastatin for lipid lowering in patients with coronary heart disease. Oncotarget 2018; 9:9489-9497. http://www.ncbi.nlm.nih.gov/pubmed/?term=29507705
  22. Hosomi N, Kitagawa K, Nagai Y et al. Desirable Low-Density Lipoprotein Cholesterol Levels for Preventing Stroke Recurrence: A Post Hoc Analysis of J-STARS Study (Japan Statin Treatment Against Recurrent Stroke). Stroke 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29511130

Women and elderly

  1. Korhonen MJ, Ilomaki J, Sluggett JK et al. Selective prescribing of statins and the risk of mortality, hospitalizations, and falls in aged care services. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=29574073
  2. Malik M, Tasnim N, Mahmud G. Effect of Metformin Alone Compared with Metformin Plus Simvastatin on Polycystic Ovarian Syndrome in Pakistani Women. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2018; 28:184-187. http://www.ncbi.nlm.nih.gov/pubmed/?term=29544572
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