up-to-date with a click!
Update August, 2018
 
Curated by Peter Lansberg,
a Dutch lipidologist and educator, and
reviewed by prof. Philip Barter, Past President of the
International Atherosclerosis Society.
The IAS Statin Newsletter will keep you up-to-date with all recent statin publications, using a curated approach to select relevant articles.

Statin publications August 2018

Add on treatments

  1. Brum J, Ramsey D, McRorie J et al. Meta-Analysis of Usefulness of Psyllium Fiber as Adjuvant Antilipid Therapy to Enhance Cholesterol Lowering Efficacy of Statins. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078477
  2. Khan SZ, Rivero M, Cherr GS et al. Metformin Is Associated with Improved Survival and Decreased Cardiac Events With No Impact on Patency and Limb Salvage After Revascularization for Peripheral Arterial Disease. Annals of vascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30081159
  3. El-Kharashi OA, El-Din Aly El-Waseef DA, Nabih ES, Mohamed DI. Targeting NLRP3 inflammasome via acetylsalicylic acid: Role in suppressing hepatic dysfunction and insulin resistance induced by atorvastatin in naive versus alcoholic liver in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018; 107:665-674. http://www.ncbi.nlm.nih.gov/pubmed/?term=30118883
  4. Nicholls SJ, Lincoff AM, Bash D et al. Assessment of Omega-3 Carboxylic Acids in Statin Treated Patients with High Levels of Triglycerides and Low Levels of High Density Lipoprotein Cholesterol: Rationale and Design of the STRENGTH Trial. Clin Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30125052
  5. Bae JC, Min KW, Kim YH et al. Efficacy and safety of fixed-dose comBination therApy with gemigLiptin (50 mg) and rosuvAstatiN (20 mg) Compared with Each monotherapy in patients with type 2 diabetes and dyslipidaemia (BALANCE): A multicentre, randomized, double-blind, controlled, phase 3 trial. Diabetes Obes Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084112
  6. Tani S, Matsuo R, Hirayama A. Does administration of eicosapentaenoic acid increase soluble thrombomodulin level in statin-treated patients with stable coronary artery disease? Heart Vessels 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30143885
  7. Probstfield JL, Boden WE, Anderson T et al. Cardiovascular outcomes during extended follow-up of the AIM-HIGH trial cohort. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30131256
  8. Wang Y, Jin Y, Yun X et al. Co-administration with simvastatin or lovastatin alters the pharmacokinetic profile of sinomenine in rats through cytochrome P450-mediated pathways. Life sciences 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30096386
  9. Martinez-Jimenez C, Cruz-Angeles J, Videa M, Martinez LM. Co-Amorphous Simvastatin-Nifedipine with Enhanced Solubility for Possible Use in Combination Therapy of Hypertension and Hypercholesterolemia. Molecules (Basel, Switzerland) 2018; 23. http://www.ncbi.nlm.nih.gov/pubmed/?term=30154310
  10. Ciric D, Martinovic T, Petricevic S et al. Metformin exacerbates and simvastatin attenuates myelin damage in high fat diet-fed C57BL/6 J mice. Neuropathology : official journal of the Japanese Society of Neuropathology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30123961
  11. Lee YH, Hong N, Lee CJ et al. Differential association of ezetimibe-simvastatin combination with major adverse cardiovascular events in patients with or without diabetes: a retrospective propensity score-matched cohort study. Scientific reports 2018; 8:11925. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093717

Adherence

  1. Kannan S, Asch DA, Kurtzman GW et al. Patient and physician predictors of hyperlipidemia screening and statin prescription. The American journal of managed care 2018; 24:e241-e248. http://www.ncbi.nlm.nih.gov/pubmed/?term=30130024
  2. Morotti K, Lopez J, Vaupel V et al. Adherence to and Persistence With Statin Therapy in a Veteran Population. The Annals of pharmacotherapy 2018:1060028018792702. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084646
  3. Vonbank A, Drexel H, Agewall S et al. Reasons for Disparity in Statin Adherence Rates between Clinical Trials and Real World Observations. A Review. European heart journal. Cardiovascular pharmacotherapy 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30099530
  4. Riaz R, Merchant AZ, Ul Haq MS et al. Statins everyday versus alternate days: Is there a difference in myalgia rates? Indian Heart J 2018; 70:492-496. http://www.ncbi.nlm.nih.gov/pubmed/?term=30170642

Atherosclerosis & Imaging

  1. Saleh M, Alfaddagh A, Elajami TK et al. Diastolic blood pressure predicts coronary plaque volume in patients with coronary artery disease. Atherosclerosis 2018; 277:34-41. http://www.ncbi.nlm.nih.gov/pubmed/?term=30170222
  2. Yagi S, Kondo D, Ise T et al. Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome. J Atheroscler Thromb 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30135329
  3. Venardos N, Deng XS, Yao Q et al. Simvastatin reduces the TLR4-induced inflammatory response in human aortic valve interstitial cells. J Surg Res 2018; 230:101-109. http://www.ncbi.nlm.nih.gov/pubmed/?term=30100024
  4. Kulik A, Abreu AM, Boronat V, Ruel M. Intensive versus moderate statin therapy and early graft occlusion after coronary bypass surgery: The Aggressive Cholesterol Therapy to Inhibit Vein Graft Events randomized clinical trial. The Journal of thoracic and cardiovascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30122341
  5. Bajnok L. [Newer evidences and recommendations in lipidology]. Orvosi hetilap 2018; 159:1303-1309. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078359
  6. Hari P, Khandelwal P, Satpathy A et al. Effect of atorvastatin on dyslipidemia and carotid intima-media thickness in children with refractory nephrotic syndrome: a randomized controlled trial. Pediatric nephrology (Berlin, Germany) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30091061
  7. DuBrock HM, AbouEzzeddine OF, Redfield MM. High-sensitivity C-reactive protein in heart failure with preserved ejection fraction. PLoS One 2018; 13:e0201836. http://www.ncbi.nlm.nih.gov/pubmed/?term=30114262
  8. Salem MM, Maragkos GA, Enriquez-Marulanda A et al. Statin Therapy and Diabetes Do Not Affect Aneurysm Occlusion or Clinical Outcomes Following Pipeline Embolization Device Treatment: a Preliminary Study. World neurosurgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30149155

Atorvastatin/Rosuvastatin

  1. Shanbhag A, Ananthula A, Reddy Palagiri RD et al. Variation in High-Intensity Statin Use After Hospitalization for Acute Vascular Emergencies. Am J Med Sci 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30082029
  2. Veronese N, Koyanagi A, Stubbs B et al. Statin use and knee osteoarthritis outcomes: A longitudinal cohort study. Arthritis care & research 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30144308
  3. El-Kharashi OA, El-Din Aly El-Waseef DA, Nabih ES, Mohamed DI. Targeting NLRP3 inflammasome via acetylsalicylic acid: Role in suppressing hepatic dysfunction and insulin resistance induced by atorvastatin in naive versus alcoholic liver in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018; 107:665-674. http://www.ncbi.nlm.nih.gov/pubmed/?term=30118883
  4. Yu B, Liu D, Zhang H et al. Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018; 106:1390-1395. http://www.ncbi.nlm.nih.gov/pubmed/?term=30119211
  5. Donald Harvey R, Aransay NR, Isambert N et al. Effect of multiple-dose osimertinib on the pharmacokinetics of simvastatin and rosuvastatin. Br J Clin Pharmacol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30171779
  6. Hsu RK, Truwit JD, Matthay MA et al. Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome. Canadian journal of kidney health and disease 2018; 5:2054358118789158. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116543
  7. Giustino G, Colantonio LD, Brown TM et al. Titration to High-Intensity Statin Therapy Following Acute Myocardial Infarction in Patients With and Without Diabetes Mellitus. Cardiovasc Drugs Ther 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078077
  8. Al-Zakwani I, Zubaid M, Alsheikh-Ali AA et al. Effect of evidence-based cardiac drug therapy on mortality in patients with acute coronary syndrome: Findings from the Gulf COAST registry. Cardiovasc Ther 2018:e12463. http://www.ncbi.nlm.nih.gov/pubmed/?term=30079461
  9. Yang N, Song Y, Dong B et al. Elevated Interleukin-38 Level Associates with Clinical Response to Atorvastatin in Patients with Hyperlipidemia. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018; 49:653-661. http://www.ncbi.nlm.nih.gov/pubmed/?term=30165364
  10. Wang M, Li J, Shi H et al. Photolysis of atorvastatin in aquatic environment: Influencing factors, products, and pathways. Chemosphere 2018; 212:467-475. http://www.ncbi.nlm.nih.gov/pubmed/?term=30153618
  11. Bae JC, Min KW, Kim YH et al. Efficacy and safety of fixed-dose comBination therApy with gemigLiptin (50 mg) and rosuvAstatiN (20 mg) Compared with Each monotherapy in patients with type 2 diabetes and dyslipidaemia (BALANCE): A multicentre, randomized, double-blind, controlled, phase 3 trial. Diabetes Obes Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084112
  12. Choi Y, Lee S, Jang IJ, Yu KS. Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers. Drug design, development and therapy 2018; 12:2301-2309. http://www.ncbi.nlm.nih.gov/pubmed/?term=30087555
  13. Aldalaen S, El-Gogary RI, Nasr M. Fabrication of rosuvastatin-loaded polymeric nanocapsules: A promising modality for treating hepatic cancer delineated by apoptotic and cell cycle arrest assessment. Drug development and industrial pharmacy 2018:1-29. http://www.ncbi.nlm.nih.gov/pubmed/?term=30139281
  14. Isilay Ozdogan A, Akca G, Senel S. Development and in vitro evaluation of chitosan based system for local delivery of atorvastatin for treatment of periodontitis. Eur J Pharm Sci 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30171985
  15. Krysiak R, Szkrobka W, Okopien B. The Relationship Between Statin Action On Thyroid Autoimmunity And Vitamin D Status: A Pilot Study. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30149415
  16. Li M, Liu F, Sang M et al. Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. Experimental and therapeutic medicine 2018; 16:751-757. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116330
  17. Godoy JC, Niesman IR, Busija AR et al. Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018:fj201800876R. http://www.ncbi.nlm.nih.gov/pubmed/?term=30169110
  18. Lu D, Liu Y, Mai H et al. Rosuvastatin Reduces Neuroinflammation in the Hemorrhagic Transformation After rt-PA Treatment in a Mouse Model of Experimental Stroke. Frontiers in cellular neuroscience 2018; 12:225. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116175
  19. Bostanitis I, Tsalidou M. Atorvastatin induced gynecomastia in a dyslipidemic patient. A case report. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30145234
  20. Krysiak R, Szkrobka W, Okopien B. Different Effects of Atorvastatin on Cardiometabolic Risk Factors in Young Women With and Without Hyperprolactinemia. Journal of clinical pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30129670
  21. Al-Kuraishy HM, Al-Gareeb AI, Al-Buhadily AK. Rosuvastatin as forthcoming antibiotic or as adjuvant additive agent: In vitro novel antibacterial study. Journal of laboratory physicians 2018; 10:271-275. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078961
  22. Mirzaei-Kalar Z. In vitro binding interaction of atorvastatin with calf thymus DNA: multispectroscopic, gel electrophoresis and molecular docking studies. Journal of pharmaceutical and biomedical analysis 2018; 161:101-109. http://www.ncbi.nlm.nih.gov/pubmed/?term=30145447
  23. Xia B, Li Y, Zhang Y et al. UHPLC-MS/MS method for determination of atorvastatin calcium in human plasma: Application to a pharmacokinetic study based on healthy volunteers with specific genotype. Journal of pharmaceutical and biomedical analysis 2018; 160:428-435. http://www.ncbi.nlm.nih.gov/pubmed/?term=30130726
  24. Cheng ZJ, Dai TM, Shen YY et al. Atorvastatin Pretreatment Attenuates Ischemic Brain Edema by Suppressing Aquaporin 4. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093197
  25. Kulik A, Abreu AM, Boronat V, Ruel M. Intensive versus moderate statin therapy and early graft occlusion after coronary bypass surgery: The Aggressive Cholesterol Therapy to Inhibit Vein Graft Events randomized clinical trial. The Journal of thoracic and cardiovascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30122341
  26. Kim C, Choi D. Timing of high intensity statin for acute coronary syndrome: how earlier initiation makes better? J Thorac Dis 2018; 10:S2149-s2152. http://www.ncbi.nlm.nih.gov/pubmed/?term=30123546
  27. Leite GAA, Figueiredo TM, Pacheco TL et al. Reproductive outcomes in rat female offspring from male rats co-exposed to rosuvastatin and ascorbic acid during pre-puberty. Journal of toxicology and environmental health. Part A 2018:1-20. http://www.ncbi.nlm.nih.gov/pubmed/?term=30081759
  28. Oleynikov VE, Dushina EV, Barmenkova YA et al. [The Impact of Effective Therapy With Atorvastatin on the Dynamics of Parameters of Electrical Instability in Patients with ST-Elevation Myocardial Infarction]. Kardiologiia 2018:18-24. http://www.ncbi.nlm.nih.gov/pubmed/?term=30131038
  29. Gupta A, Mackay J, Whitehouse A et al. Long-term mortality after blood pressure-lowering and lipid-lowering treatment in patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Legacy study: 16-year follow-up results of a randomised factorial trial. Lancet 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30158072
  30. Mijailovic N, Selakovic D, Joksimovic J et al. The anxiolytic effects of atorvastatin and simvastatin on dietary-induced increase in homocysteine levels in rats. Molecular and cellular biochemistry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30120639
  31. Hari P, Khandelwal P, Satpathy A et al. Effect of atorvastatin on dyslipidemia and carotid intima-media thickness in children with refractory nephrotic syndrome: a randomized controlled trial. Pediatric nephrology (Berlin, Germany) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30091061
  32. Soko ND, Chimusa E, Masimirembwa C, Dandara C. An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C. Pharmacogenomics J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30100615
  33. Li N, Wen C, Huang P et al. Atorvastatin reduces alcohol-induced endoplasmic reticulum stress in AC16 cardiomyocytes. Scandinavian cardiovascular journal : SCJ 2018:1-20. http://www.ncbi.nlm.nih.gov/pubmed/?term=30160187
  34. Streja E, Streja DA, Soohoo M et al. Precision Medicine and Personalized Management of Lipoprotein and Lipid Disorders in Chronic and End-Stage Kidney Disease. Seminars in nephrology 2018; 38:369-382. http://www.ncbi.nlm.nih.gov/pubmed/?term=30082057

Basic science

  1. Balraj J, Jairaman K, Kalieswaran V, Jayaraman A. Bioprospecting lovastatin production from a novel producer Cunninghamella blakesleeana. 3 Biotech 2018; 8:359. http://www.ncbi.nlm.nih.gov/pubmed/?term=30105184
  2. Zhang N, Liang X, Gao C et al. Loading lovastatin into camptothecin-floxuridine conjugate nanocapsules for enhancing anti-metastatic efficacy of cocktail chemotherapy on triple-negative breast cancer. ACS applied materials & interfaces 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30096224
  3. Xue D, Gong Z, Zhu F et al. Simvastatin increases cell viability and suppresses the expression of cytokines and vascular endothelial growth factor in inflamed human dental pulp stem cells in vitro. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30088351
  4. Kim JH, Lee JM, Kim JH, Kim KR. Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells. Biochem Biophys Res Commun 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078674
  5. Yu B, Liu D, Zhang H et al. Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018; 106:1390-1395. http://www.ncbi.nlm.nih.gov/pubmed/?term=30119211
  6. Habibi H, Atashi A, Abroun S, Noruzinia M. Synergistic Effect of Simvastatin and Romidepsin on Gamma-globin Gene Induction. Cell journal 2019; 20:576-583. http://www.ncbi.nlm.nih.gov/pubmed/?term=30124006
  7. Wang M, Li J, Shi H et al. Photolysis of atorvastatin in aquatic environment: Influencing factors, products, and pathways. Chemosphere 2018; 212:467-475. http://www.ncbi.nlm.nih.gov/pubmed/?term=30153618
  8. Aldalaen S, El-Gogary RI, Nasr M. Fabrication of rosuvastatin-loaded polymeric nanocapsules: A promising modality for treating hepatic cancer delineated by apoptotic and cell cycle arrest assessment. Drug development and industrial pharmacy 2018:1-29. http://www.ncbi.nlm.nih.gov/pubmed/?term=30139281
  9. Mast N, Bederman IR, Pikuleva IA. Retinal Cholesterol Content is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol. Drug metabolism and disposition: the biological fate of chemicals 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30115644
  10. Isilay Ozdogan A, Akca G, Senel S. Development and in vitro evaluation of chitosan based system for local delivery of atorvastatin for treatment of periodontitis. Eur J Pharm Sci 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30171985
  11. Jia L, Wang L, Liu W et al. Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway. Experimental and therapeutic medicine 2018; 16:1350-1354. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116385
  12. Li M, Liu F, Sang M et al. Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. Experimental and therapeutic medicine 2018; 16:751-757. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116330
  13. Godoy JC, Niesman IR, Busija AR et al. Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018:fj201800876R. http://www.ncbi.nlm.nih.gov/pubmed/?term=30169110
  14. Lu D, Liu Y, Mai H et al. Rosuvastatin Reduces Neuroinflammation in the Hemorrhagic Transformation After rt-PA Treatment in a Mouse Model of Experimental Stroke. Frontiers in cellular neuroscience 2018; 12:225. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116175
  15. Arany I, Fulop T, Dixit M. Chronic Nicotine Exposure Reduces Antioxidant Function of Simvastatin in Renal Proximal Tubule Cells. In Vivo 2018; 32:1033-1037. http://www.ncbi.nlm.nih.gov/pubmed/?term=30150424
  16. Xiao H, Hwang JE, Wu R. Mass spectrometric analysis of the N-glycoproteome in statin-treated liver cells with two lectin-independent chemical enrichment methods. International journal of mass spectrometry 2018; 429:66-75. http://www.ncbi.nlm.nih.gov/pubmed/?term=30147434
  17. Kong Y, Cheng L, Mao F et al. Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC). The Journal of biological chemistry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30089652
  18. Lai M, Yan X, Jin Z. The response of bone cells to titanium surfaces modified by simvastatin-loaded multilayered films. Journal of biomaterials science. Polymer edition 2018:1-26. http://www.ncbi.nlm.nih.gov/pubmed/?term=30156968
  19. Mo X, Zheng Z, He Y et al. Antiglioma via regulating oxidative stress and remodeling tumor-associated macrophage using lactoferrin-mediated biomimetic codelivery of simvastatin/fenretinide. J Control Release 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30096402
  20. Mirzaei-Kalar Z. In vitro binding interaction of atorvastatin with calf thymus DNA: multispectroscopic, gel electrophoresis and molecular docking studies. Journal of pharmaceutical and biomedical analysis 2018; 161:101-109. http://www.ncbi.nlm.nih.gov/pubmed/?term=30145447
  21. Xia B, Li Y, Zhang Y et al. UHPLC-MS/MS method for determination of atorvastatin calcium in human plasma: Application to a pharmacokinetic study based on healthy volunteers with specific genotype. Journal of pharmaceutical and biomedical analysis 2018; 160:428-435. http://www.ncbi.nlm.nih.gov/pubmed/?term=30130726
  22. Cheng ZJ, Dai TM, Shen YY et al. Atorvastatin Pretreatment Attenuates Ischemic Brain Edema by Suppressing Aquaporin 4. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093197
  23. Venardos N, Deng XS, Yao Q et al. Simvastatin reduces the TLR4-induced inflammatory response in human aortic valve interstitial cells. J Surg Res 2018; 230:101-109. http://www.ncbi.nlm.nih.gov/pubmed/?term=30100024
  24. Leite GAA, Figueiredo TM, Pacheco TL et al. Reproductive outcomes in rat female offspring from male rats co-exposed to rosuvastatin and ascorbic acid during pre-puberty. Journal of toxicology and environmental health. Part A 2018:1-20. http://www.ncbi.nlm.nih.gov/pubmed/?term=30081759
  25. Zhang X, Hong S, Yen R et al. A system to monitor statin-induced myopathy in individual engineered skeletal muscle myobundles. Lab on a chip 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30112530
  26. Wang Y, Jin Y, Yun X et al. Co-administration with simvastatin or lovastatin alters the pharmacokinetic profile of sinomenine in rats through cytochrome P450-mediated pathways. Life sciences 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30096386
  27. Ahmadi M, Madrakian T, Ghavami S. Preparation and Characterization of Simvastatin Nanocapsules: Encapsulation of Hydrophobic Drugs in Calcium Alginate. Methods in molecular biology (Clifton, N.J.) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30159829
  28. Martinez-Jimenez C, Cruz-Angeles J, Videa M, Martinez LM. Co-Amorphous Simvastatin-Nifedipine with Enhanced Solubility for Possible Use in Combination Therapy of Hypertension and Hypercholesterolemia. Molecules (Basel, Switzerland) 2018; 23. http://www.ncbi.nlm.nih.gov/pubmed/?term=30154310
  29. McCarthy C, Lee E, Bridges JP et al. Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nature communications 2018; 9:3127. http://www.ncbi.nlm.nih.gov/pubmed/?term=30087322
  30. Lapczuk-Romanska J, Wajda A, Pius-Sadowska E et al. Effects of simvastatin on nuclear receptors, drug metabolizing enzymes and transporters expression in Human Umbilical Vein Endothelial Cells. Pharmacological reports : PR 2018; 70:875-880. http://www.ncbi.nlm.nih.gov/pubmed/?term=30092417
  31. Bahrami A, Parsamanesh N, Atkin SL et al. Effect of statins on toll-like receptors: a new insight to pleiotropic effects. Pharmacol Res 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30120976
  32. Oda Y, Sasaki H, Miura T et al. Bone marrow stromal cells from low-turnover osteoporotic mouse model are less sensitive to the osteogenic effects of fluvastatin. PLoS One 2018; 13:e0202857. http://www.ncbi.nlm.nih.gov/pubmed/?term=30142209
  33. Rauca VF, Licarete E, Luput L et al. Combination therapy of simvastatin and 5, 6-dimethylxanthenone-4-acetic acid synergistically suppresses the aggressiveness of B16.F10 melanoma cells. PLoS One 2018; 13:e0202827. http://www.ncbi.nlm.nih.gov/pubmed/?term=30138430
  34. Alqudah MAY, Mansour HT, Mhaidat N. Simvastatin enhances irinotecan-induced apoptosis in prostate cancer via inhibition of MCL-1. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 2018; 26:191-197. http://www.ncbi.nlm.nih.gov/pubmed/?term=30166915
  35. Li N, Wen C, Huang P et al. Atorvastatin reduces alcohol-induced endoplasmic reticulum stress in AC16 cardiomyocytes. Scandinavian cardiovascular journal : SCJ 2018:1-20. http://www.ncbi.nlm.nih.gov/pubmed/?term=30160187
  36. Kim K, Theusch E, Kuang YL et al. ZNF542P is a pseudogene associated with LDL response to simvastatin treatment. Scientific reports 2018; 8:12443. http://www.ncbi.nlm.nih.gov/pubmed/?term=30127457

Cancer

  1. Henslee AB, Steele TA. Combination statin and chemotherapy inhibits proliferation and cytotoxicity of an aggressive natural killer cell leukemia. Biomarker research 2018; 6:26. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116531
  2. Donald Harvey R, Aransay NR, Isambert N et al. Effect of multiple-dose osimertinib on the pharmacokinetics of simvastatin and rosuvastatin. Br J Clin Pharmacol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30171779
  3. Aldalaen S, El-Gogary RI, Nasr M. Fabrication of rosuvastatin-loaded polymeric nanocapsules: A promising modality for treating hepatic cancer delineated by apoptotic and cell cycle arrest assessment. Drug development and industrial pharmacy 2018:1-29. http://www.ncbi.nlm.nih.gov/pubmed/?term=30139281
  4. Dobrzycka M, Spychalski P, Lachinski AJ et al. Statins and Colorectal Cancer - A Systematic Review. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30149418
  5. Iarrobino NA, Gill BS, Bernard M et al. The Impact of Serum Glucose, Anti-Diabetic Agents, and Statin Usage in Non-small Cell Lung Cancer Patients Treated With Definitive Chemoradiation. Frontiers in oncology 2018; 8:281. http://www.ncbi.nlm.nih.gov/pubmed/?term=30101126
  6. Kong Y, Cheng L, Mao F et al. Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC). The Journal of biological chemistry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30089652
  7. Rauca VF, Licarete E, Luput L et al. Combination therapy of simvastatin and 5, 6-dimethylxanthenone-4-acetic acid synergistically suppresses the aggressiveness of B16.F10 melanoma cells. PLoS One 2018; 13:e0202827. http://www.ncbi.nlm.nih.gov/pubmed/?term=30138430
  8. Alqudah MAY, Mansour HT, Mhaidat N. Simvastatin enhances irinotecan-induced apoptosis in prostate cancer via inhibition of MCL-1. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 2018; 26:191-197. http://www.ncbi.nlm.nih.gov/pubmed/?term=30166915

Children

  1. Radaelli G, Sausen G, Cesa CC et al. Secondary Dyslipidemia In Obese Children - Is There Evidence For Pharmacological Treatment? Arquivos brasileiros de cardiologia 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30156604
  2. Hari P, Khandelwal P, Satpathy A et al. Effect of atorvastatin on dyslipidemia and carotid intima-media thickness in children with refractory nephrotic syndrome: a randomized controlled trial. Pediatric nephrology (Berlin, Germany) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30091061

Cost-effectiveness

  1. Nichols GA, Philip S, Reynolds K et al. Comparison of Medical Care Utilization and Costs Among Patients With Statin-Controlled Low-Density Lipoprotein Cholesterol With Versus Without Hypertriglyceridemia. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30086877
  2. Roughead EE, Kim DS, Ong B, Kemp-Casey A. Pricing policies for generic medicines in Australia, New Zealand, the Republic of Korea and Singapore: patent expiry and influence on atorvastatin price. WHO South-East Asia journal of public health 2018; 7:99-106. http://www.ncbi.nlm.nih.gov/pubmed/?term=30136668

CVD

  1. Bakhai S, Bhardwaj A, Sandhu P, Reynolds JL. Optimisation of lipids for prevention of cardiovascular disease in a primary care. BMJ open quality 2018; 7:e000071. http://www.ncbi.nlm.nih.gov/pubmed/?term=30167469
  2. Sun Y, Xie G, Patel A et al. Prescription of statins at discharge and one-year risk of major clinical outcomes among ACS patients with extremely low LDL-c in CPACS studies. Clin Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084224
  3. Bauer UMM, Korten MA, Diller GP et al. Cardiovascular risk factors in adults with congenital heart defects - Recognised but not treated? An analysis of the German National Register for Congenital Heart Defects. Int J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30100225
  4. Kulik A, Abreu AM, Boronat V, Ruel M. Intensive versus moderate statin therapy and early graft occlusion after coronary bypass surgery: The Aggressive Cholesterol Therapy to Inhibit Vein Graft Events randomized clinical trial. The Journal of thoracic and cardiovascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30122341
  5. Bergt S, Grub A, Wagner S et al. Pravastatin But Not Simvastatin Improves Survival and Neurofunctional Outcome After Cardiac Arrest and Cardiopulmonary Resuscitation. JACC. Basic to translational science 2017; 2:149-159. http://www.ncbi.nlm.nih.gov/pubmed/?term=30167563
  6. DuBrock HM, AbouEzzeddine OF, Redfield MM. High-sensitivity C-reactive protein in heart failure with preserved ejection fraction. PLoS One 2018; 13:e0201836. http://www.ncbi.nlm.nih.gov/pubmed/?term=30114262
  7. Lee YH, Hong N, Lee CJ et al. Differential association of ezetimibe-simvastatin combination with major adverse cardiovascular events in patients with or without diabetes: a retrospective propensity score-matched cohort study. Scientific reports 2018; 8:11925. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093717
  8. Tyerman Z, Hawkins RB, Mehaffey JH et al. Preoperative Statin Use Not Associated with Improved Outcomes After Ascending Aortic Repair (91 / 100). Seminars in thoracic and cardiovascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30102969

Endothelium/inflammation

  1. El-Kharashi OA, El-Din Aly El-Waseef DA, Nabih ES, Mohamed DI. Targeting NLRP3 inflammasome via acetylsalicylic acid: Role in suppressing hepatic dysfunction and insulin resistance induced by atorvastatin in naive versus alcoholic liver in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018; 107:665-674. http://www.ncbi.nlm.nih.gov/pubmed/?term=30118883
  2. Lu D, Liu Y, Mai H et al. Rosuvastatin Reduces Neuroinflammation in the Hemorrhagic Transformation After rt-PA Treatment in a Mouse Model of Experimental Stroke. Frontiers in cellular neuroscience 2018; 12:225. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116175

Ethnicity

  1. Ha KH, Lee YH, Song SO et al. Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study. Diabetes Metab J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30113144
  2. Bae JC, Min KW, Kim YH et al. Efficacy and safety of fixed-dose comBination therApy with gemigLiptin (50 mg) and rosuvAstatiN (20 mg) Compared with Each monotherapy in patients with type 2 diabetes and dyslipidaemia (BALANCE): A multicentre, randomized, double-blind, controlled, phase 3 trial. Diabetes Obes Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084112

Generics

  1. Roughead EE, Kim DS, Ong B, Kemp-Casey A. Pricing policies for generic medicines in Australia, New Zealand, the Republic of Korea and Singapore: patent expiry and influence on atorvastatin price. WHO South-East Asia journal of public health 2018; 7:99-106. http://www.ncbi.nlm.nih.gov/pubmed/?term=30136668

Genetics

  1. Vassy JL, Chun S, Advani S et al. Impact of SLCO1B1 pharmacogenetic testing on patient and healthcare outcomes: A systematic review. Clinical pharmacology and therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30137643
  2. Soko ND, Chimusa E, Masimirembwa C, Dandara C. An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C. Pharmacogenomics J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30100615
  3. Chen YC, Xu C, Zhang JG et al. Multivariate analysis of genomics data to identify potential pleiotropic genes for type 2 diabetes, obesity and dyslipidemia using Meta-CCA and gene-based approach. PLoS One 2018; 13:e0201173. http://www.ncbi.nlm.nih.gov/pubmed/?term=30110382
  4. Kim K, Theusch E, Kuang YL et al. ZNF542P is a pseudogene associated with LDL response to simvastatin treatment. Scientific reports 2018; 8:12443. http://www.ncbi.nlm.nih.gov/pubmed/?term=30127457

Guidelines

  1. Kannan S, Asch DA, Kurtzman GW et al. Patient and physician predictors of hyperlipidemia screening and statin prescription. The American journal of managed care 2018; 24:e241-e248. http://www.ncbi.nlm.nih.gov/pubmed/?term=30130024
  2. Ferrieres J, Gorcyca K, Iorga SR et al. Lipid-lowering Therapy and Goal Achievement in High-risk Patients From French General Practice. Clinical therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30126705
  3. Mantsiou C, Tziomalos K. Strategies to achieve low-density lipoprotein cholesterol targets in high-risk patients. Current medical research and opinion 2018:1-5. http://www.ncbi.nlm.nih.gov/pubmed/?term=30086667
  4. Ha KH, Lee YH, Song SO et al. Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study. Diabetes Metab J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30113144
  5. Bauer UMM, Korten MA, Diller GP et al. Cardiovascular risk factors in adults with congenital heart defects - Recognised but not treated? An analysis of the German National Register for Congenital Heart Defects. Int J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30100225
  6. Howard G, Schwamm LH, Donnelly JP et al. Participation in Get With the Guidelines-Stroke and Its Association With Quality of Care for Stroke. JAMA neurology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30083763
  7. Streja E, Streja DA, Soohoo M et al. Precision Medicine and Personalized Management of Lipoprotein and Lipid Disorders in Chronic and End-Stage Kidney Disease. Seminars in nephrology 2018; 38:369-382. http://www.ncbi.nlm.nih.gov/pubmed/?term=30082057

LDL- related parameters

  1. Saleh M, Alfaddagh A, Elajami TK et al. Diastolic blood pressure predicts coronary plaque volume in patients with coronary artery disease. Atherosclerosis 2018; 277:34-41. http://www.ncbi.nlm.nih.gov/pubmed/?term=30170222
  2. Sun Y, Xie G, Patel A et al. Prescription of statins at discharge and one-year risk of major clinical outcomes among ACS patients with extremely low LDL-c in CPACS studies. Clin Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084224
  3. Ferrieres J, Gorcyca K, Iorga SR et al. Lipid-lowering Therapy and Goal Achievement in High-risk Patients From French General Practice. Clinical therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30126705
  4. Langlois MR, Nordestgaard BG. Which Lipids Should Be Analyzed for Diagnostic Workup and Follow-up of Patients with Hyperlipidemias? Current cardiology reports 2018; 20:88. http://www.ncbi.nlm.nih.gov/pubmed/?term=30120626
  5. Bajnok L. [Newer evidences and recommendations in lipidology]. Orvosi hetilap 2018; 159:1303-1309. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078359

Lifestyle

  1. Baptista LC, Verissimo MT, Martins RA. Statin combined with exercise training is more effective to improve functional status in dyslipidemic older adults. Scandinavian journal of medicine & science in sports 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30137683

Meta-analyses

  1. Brum J, Ramsey D, McRorie J et al. Meta-Analysis of Usefulness of Psyllium Fiber as Adjuvant Antilipid Therapy to Enhance Cholesterol Lowering Efficacy of Statins. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078477
  2. Dobrzycka M, Spychalski P, Lachinski AJ et al. Statins and Colorectal Cancer - A Systematic Review. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30149418
  3. Texakalidis P, Giannopoulos S, Jonnalagadda AK et al. Preoperative Use of Statins in Carotid Artery Stenting: A Systematic Review and Meta-analysis. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 2018:1526602818794030. http://www.ncbi.nlm.nih.gov/pubmed/?term=30101624
  4. Ziff OJ, Banerjee G, Ambler G, Werring DJ. Statins and the risk of intracerebral haemorrhage inpatients withstroke:systematic review and meta-analysis. Journal of neurology, neurosurgery, and psychiatry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30150320
  5. Li Z, Li Y, Li X et al. Statins on hepatocellular carcinoma risk in hepatitis B or C patients protocol for a systematic review and meta-analysis. Medicine (Baltimore) 2018; 97:e11950. http://www.ncbi.nlm.nih.gov/pubmed/?term=30142817

Metabolic Syndrome - Diabetes

  1. Khan SZ, Rivero M, Cherr GS et al. Metformin Is Associated with Improved Survival and Decreased Cardiac Events With No Impact on Patency and Limb Salvage After Revascularization for Peripheral Arterial Disease. Annals of vascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30081159
  2. Giustino G, Colantonio LD, Brown TM et al. Titration to High-Intensity Statin Therapy Following Acute Myocardial Infarction in Patients With and Without Diabetes Mellitus. Cardiovasc Drugs Ther 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078077
  3. Ha KH, Lee YH, Song SO et al. Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study. Diabetes Metab J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30113144
  4. Bae JC, Min KW, Kim YH et al. Efficacy and safety of fixed-dose comBination therApy with gemigLiptin (50 mg) and rosuvAstatiN (20 mg) Compared with Each monotherapy in patients with type 2 diabetes and dyslipidaemia (BALANCE): A multicentre, randomized, double-blind, controlled, phase 3 trial. Diabetes Obes Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084112
  5. Baubeta Fridh E, Andersson M, Thuresson M et al. Impact of Comorbidity, Medication, and Gender on Amputation Rate Following Revascularisation for Chronic Limb Threatening Ischaemia. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093176
  6. Porath A, Arbelle JE, Fund N et al. Statin Therapy: Diabetes Mellitus Risk and Cardiovascular Benefit in Primary Prevention. The Israel Medical Association journal : IMAJ 2018; 20:480-485. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084572
  7. Lee YH, Hong N, Lee CJ et al. Differential association of ezetimibe-simvastatin combination with major adverse cardiovascular events in patients with or without diabetes: a retrospective propensity score-matched cohort study. Scientific reports 2018; 8:11925. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093717
  8. Salem MM, Maragkos GA, Enriquez-Marulanda A et al. Statin Therapy and Diabetes Do Not Affect Aneurysm Occlusion or Clinical Outcomes Following Pipeline Embolization Device Treatment: a Preliminary Study. World neurosurgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30149155 

New Treatments

  1. Vincent J. Lipid Lowering Therapy for Atherosclerotic Cardiovascular Disease: It Is Not So Simple. Clinical pharmacology and therapeutics 2018; 104:220-224. http://www.ncbi.nlm.nih.gov/pubmed/?term=30117592
  2. Alkhalil M. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, reality or dream in managing patients with cardiovascular disease. Current drug metabolism 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30112987
  3. Mantsiou C, Tziomalos K. Strategies to achieve low-density lipoprotein cholesterol targets in high-risk patients. Current medical research and opinion 2018:1-5. http://www.ncbi.nlm.nih.gov/pubmed/?term=30086667

Other

  1. Correction: Statin wars: have we been misled about the evidence? A narrative review. British journal of sports medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30131331

PAD and statins

  1. Baubeta Fridh E, Andersson M, Thuresson M et al. Impact of Comorbidity, Medication, and Gender on Amputation Rate Following Revascularisation for Chronic Limb Threatening Ischaemia. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093176
  2. Williams CR, Jellison A, Martin L et al. Optimal medical management before lower extremity bypass for claudication in the veteran population. Journal of vascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30108008

Pleiotropic effects of statins

  1. Yu B, Liu D, Zhang H et al. Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018; 106:1390-1395. http://www.ncbi.nlm.nih.gov/pubmed/?term=30119211
  2. Hsu RK, Truwit JD, Matthay MA et al. Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome. Canadian journal of kidney health and disease 2018; 5:2054358118789158. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116543
  3. Habibi H, Atashi A, Abroun S, Noruzinia M. Synergistic Effect of Simvastatin and Romidepsin on Gamma-globin Gene Induction. Cell journal 2019; 20:576-583. http://www.ncbi.nlm.nih.gov/pubmed/?term=30124006
  4. Putra RA, Effendi JS, Permadi W et al. Role of statin as inducer of Hmox-1 system in treatment of preeclampsia. Cell Mol Biol (Noisy-le-grand) 2018; 64:1-4. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084810
  5. Vincent J. Lipid Lowering Therapy for Atherosclerotic Cardiovascular Disease: It Is Not So Simple. Clinical pharmacology and therapeutics 2018; 104:220-224. http://www.ncbi.nlm.nih.gov/pubmed/?term=30117592
  6. Ahmadvand A, Yazdanfar A, Yasrebifar F et al. Evaluation the effects of oral and topical simvastatin as adjunct therapy in the treatment of acne vulgaris. Current clinical pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30129417
  7. Liao JK, Oesterle A. The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia. Current vascular pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30124154
  8. Isilay Ozdogan A, Akca G, Senel S. Development and in vitro evaluation of chitosan based system for local delivery of atorvastatin for treatment of periodontitis. Eur J Pharm Sci 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30171985
  9. Krysiak R, Szkrobka W, Okopien B. The Relationship Between Statin Action On Thyroid Autoimmunity And Vitamin D Status: A Pilot Study. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30149415
  10. Jia L, Wang L, Liu W et al. Fluvastatin inhibits cardiomyocyte apoptosis after myocardial infarction through Toll pathway. Experimental and therapeutic medicine 2018; 16:1350-1354. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116385
  11. Li M, Liu F, Sang M et al. Effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. Experimental and therapeutic medicine 2018; 16:751-757. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116330
  12. Rajeshuni N, Ludwig CA, Moshfeghi DM. The effect of statin exposure on choroidal neovascularization in nonexudative age-related macular degeneration patients. Eye (London, England) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30120400
  13. Rana R, Sharma R, Kumar A. Repurposing of Existing Statin drugs for treatment of Microbial Infections: How much Promising? Infectious disorders drug targets 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30081793
  14. Lai M, Yan X, Jin Z. The response of bone cells to titanium surfaces modified by simvastatin-loaded multilayered films. Journal of biomaterials science. Polymer edition 2018:1-26. http://www.ncbi.nlm.nih.gov/pubmed/?term=30156968
  15. Alghofaily M, Tordik P, Romberg E et al. Healing of Apical Periodontitis after Nonsurgical Root Canal Treatment: The Role of Statin Intake. Journal of endodontics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078575
  16. Al-Kuraishy HM, Al-Gareeb AI, Al-Buhadily AK. Rosuvastatin as forthcoming antibiotic or as adjuvant additive agent: In vitro novel antibacterial study. Journal of laboratory physicians 2018; 10:271-275. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078961
  17. Cheng ZJ, Dai TM, Shen YY et al. Atorvastatin Pretreatment Attenuates Ischemic Brain Edema by Suppressing Aquaporin 4. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093197
  18. Kim C, Choi D. Timing of high intensity statin for acute coronary syndrome: how earlier initiation makes better? J Thorac Dis 2018; 10:S2149-s2152. http://www.ncbi.nlm.nih.gov/pubmed/?term=30123546
  19. Oleynikov VE, Dushina EV, Barmenkova YA et al. [The Impact of Effective Therapy With Atorvastatin on the Dynamics of Parameters of Electrical Instability in Patients with ST-Elevation Myocardial Infarction]. Kardiologiia 2018:18-24. http://www.ncbi.nlm.nih.gov/pubmed/?term=30131038
  20. Calfee CS, Delucchi KL, Sinha P et al. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. The lancet. Respiratory medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078618
  21. Li Z, Li Y, Li X et al. Statins on hepatocellular carcinoma risk in hepatitis B or C patients protocol for a systematic review and meta-analysis. Medicine (Baltimore) 2018; 97:e11950. http://www.ncbi.nlm.nih.gov/pubmed/?term=30142817
  22. Mijailovic N, Selakovic D, Joksimovic J et al. The anxiolytic effects of atorvastatin and simvastatin on dietary-induced increase in homocysteine levels in rats. Molecular and cellular biochemistry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30120639
  23. McCarthy C, Lee E, Bridges JP et al. Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nature communications 2018; 9:3127. http://www.ncbi.nlm.nih.gov/pubmed/?term=30087322
  24. Ciric D, Martinovic T, Petricevic S et al. Metformin exacerbates and simvastatin attenuates myelin damage in high fat diet-fed C57BL/6 J mice. Neuropathology : official journal of the Japanese Society of Neuropathology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30123961
  25. Lapczuk-Romanska J, Wajda A, Pius-Sadowska E et al. Effects of simvastatin on nuclear receptors, drug metabolizing enzymes and transporters expression in Human Umbilical Vein Endothelial Cells. Pharmacological reports : PR 2018; 70:875-880. http://www.ncbi.nlm.nih.gov/pubmed/?term=30092417
  26. Oda Y, Sasaki H, Miura T et al. Bone marrow stromal cells from low-turnover osteoporotic mouse model are less sensitive to the osteogenic effects of fluvastatin. PLoS One 2018; 13:e0202857. http://www.ncbi.nlm.nih.gov/pubmed/?term=30142209

Primary Prevention

  1. Bakhai S, Bhardwaj A, Sandhu P, Reynolds JL. Optimisation of lipids for prevention of cardiovascular disease in a primary care. BMJ open quality 2018; 7:e000071. http://www.ncbi.nlm.nih.gov/pubmed/?term=30167469

Registry data

  1. Nichols GA, Philip S, Reynolds K et al. Comparison of Medical Care Utilization and Costs Among Patients With Statin-Controlled Low-Density Lipoprotein Cholesterol With Versus Without Hypertriglyceridemia. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30086877
  2. Kannan S, Asch DA, Kurtzman GW et al. Patient and physician predictors of hyperlipidemia screening and statin prescription. The American journal of managed care 2018; 24:e241-e248. http://www.ncbi.nlm.nih.gov/pubmed/?term=30130024
  3. Shanbhag A, Ananthula A, Reddy Palagiri RD et al. Variation in High-Intensity Statin Use After Hospitalization for Acute Vascular Emergencies. Am J Med Sci 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30082029
  4. Morotti K, Lopez J, Vaupel V et al. Adherence to and Persistence With Statin Therapy in a Veteran Population. The Annals of pharmacotherapy 2018:1060028018792702. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084646
  5. Khan SZ, Rivero M, Cherr GS et al. Metformin Is Associated with Improved Survival and Decreased Cardiac Events With No Impact on Patency and Limb Salvage After Revascularization for Peripheral Arterial Disease. Annals of vascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30081159
  6. Veronese N, Koyanagi A, Stubbs B et al. Statin use and knee osteoarthritis outcomes: A longitudinal cohort study. Arthritis care & research 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30144308
  7. Giustino G, Colantonio LD, Brown TM et al. Titration to High-Intensity Statin Therapy Following Acute Myocardial Infarction in Patients With and Without Diabetes Mellitus. Cardiovasc Drugs Ther 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078077
  8. Al-Zakwani I, Zubaid M, Alsheikh-Ali AA et al. Effect of evidence-based cardiac drug therapy on mortality in patients with acute coronary syndrome: Findings from the Gulf COAST registry. Cardiovasc Ther 2018:e12463. http://www.ncbi.nlm.nih.gov/pubmed/?term=30079461
  9. Sun Y, Xie G, Patel A et al. Prescription of statins at discharge and one-year risk of major clinical outcomes among ACS patients with extremely low LDL-c in CPACS studies. Clin Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084224
  10. Tada H, Kawashiri MA, Nomura A et al. Serum triglycerides predict first cardiovascular events in diabetic patients with hypercholesterolemia and retinopathy. Eur J Prev Cardiol 2018:2047487318796989. http://www.ncbi.nlm.nih.gov/pubmed/?term=30160521
  11. Baubeta Fridh E, Andersson M, Thuresson M et al. Impact of Comorbidity, Medication, and Gender on Amputation Rate Following Revascularisation for Chronic Limb Threatening Ischaemia. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093176
  12. Bauer UMM, Korten MA, Diller GP et al. Cardiovascular risk factors in adults with congenital heart defects - Recognised but not treated? An analysis of the German National Register for Congenital Heart Defects. Int J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30100225
  13. Porath A, Arbelle JE, Fund N et al. Statin Therapy: Diabetes Mellitus Risk and Cardiovascular Benefit in Primary Prevention. The Israel Medical Association journal : IMAJ 2018; 20:480-485. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084572
  14. Ramanan VK, Przybelski SA, Graff-Radford J et al. Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults. Journal of Alzheimer's disease : JAD 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30149450
  15. Pan ML, Hsu CC, Chen YM et al. Statin Use and the Risk of Dementia in Patients with Stroke: A Nationwide Population-Based Cohort Study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30087076
  16. Williams CR, Jellison A, Martin L et al. Optimal medical management before lower extremity bypass for claudication in the veteran population. Journal of vascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30108008
  17. Howard G, Schwamm LH, Donnelly JP et al. Participation in Get With the Guidelines-Stroke and Its Association With Quality of Care for Stroke. JAMA neurology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30083763
  18. Carvalho AAS, Silva VGD, Vieira TF et al. Proposed cut-off for reactivity of anti-HMGCR and anti-SRP antibodies in patients statin-exposed and statin-unexposed. Medicine (Baltimore) 2018; 97:e11858. http://www.ncbi.nlm.nih.gov/pubmed/?term=30170376
  19. Rozani V, Gurevich T, Giladi N et al. Higher serum cholesterol and decreased Parkinson's disease risk: A statin-free cohort study. Movement disorders : official journal of the Movement Disorder Society 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30145829
  20. Lee YH, Hong N, Lee CJ et al. Differential association of ezetimibe-simvastatin combination with major adverse cardiovascular events in patients with or without diabetes: a retrospective propensity score-matched cohort study. Scientific reports 2018; 8:11925. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093717
  21. Tyerman Z, Hawkins RB, Mehaffey JH et al. Preoperative Statin Use Not Associated with Improved Outcomes After Ascending Aortic Repair (91 / 100). Seminars in thoracic and cardiovascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30102969 

Renal Disease

  1. Hsu RK, Truwit JD, Matthay MA et al. Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome. Canadian journal of kidney health and disease 2018; 5:2054358118789158. http://www.ncbi.nlm.nih.gov/pubmed/?term=30116543
  2. Hari P, Khandelwal P, Satpathy A et al. Effect of atorvastatin on dyslipidemia and carotid intima-media thickness in children with refractory nephrotic syndrome: a randomized controlled trial. Pediatric nephrology (Berlin, Germany) 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30091061
  3. Streja E, Streja DA, Soohoo M et al. Precision Medicine and Personalized Management of Lipoprotein and Lipid Disorders in Chronic and End-Stage Kidney Disease. Seminars in nephrology 2018; 38:369-382. http://www.ncbi.nlm.nih.gov/pubmed/?term=30082057  

Reviews

  1. Radaelli G, Sausen G, Cesa CC et al. Secondary Dyslipidemia In Obese Children - Is There Evidence For Pharmacological Treatment? Arquivos brasileiros de cardiologia 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30156604
  2. Bakhai S, Bhardwaj A, Sandhu P, Reynolds JL. Optimisation of lipids for prevention of cardiovascular disease in a primary care. BMJ open quality 2018; 7:e000071. http://www.ncbi.nlm.nih.gov/pubmed/?term=30167469
  3. Putra RA, Effendi JS, Permadi W et al. Role of statin as inducer of Hmox-1 system in treatment of preeclampsia. Cell Mol Biol (Noisy-le-grand) 2018; 64:1-4. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084810
  4. Vassy JL, Chun S, Advani S et al. Impact of SLCO1B1 pharmacogenetic testing on patient and healthcare outcomes: A systematic review. Clinical pharmacology and therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30137643
  5. Vincent J. Lipid Lowering Therapy for Atherosclerotic Cardiovascular Disease: It Is Not So Simple. Clinical pharmacology and therapeutics 2018; 104:220-224. http://www.ncbi.nlm.nih.gov/pubmed/?term=30117592
  6. Langlois MR, Nordestgaard BG. Which Lipids Should Be Analyzed for Diagnostic Workup and Follow-up of Patients with Hyperlipidemias? Current cardiology reports 2018; 20:88. http://www.ncbi.nlm.nih.gov/pubmed/?term=30120626
  7. Alkhalil M. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, reality or dream in managing patients with cardiovascular disease. Current drug metabolism 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30112987
  8. Mantsiou C, Tziomalos K. Strategies to achieve low-density lipoprotein cholesterol targets in high-risk patients. Current medical research and opinion 2018:1-5. http://www.ncbi.nlm.nih.gov/pubmed/?term=30086667
  9. Pasnoor M, Barohn RJ, Dimachkie MM. Toxic myopathies. Current opinion in neurology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30080718
  10. Liao JK, Oesterle A. The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia. Current vascular pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30124154
  11. Vonbank A, Drexel H, Agewall S et al. Reasons for Disparity in Statin Adherence Rates between Clinical Trials and Real World Observations. A Review. European heart journal. Cardiovascular pharmacotherapy 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30099530
  12. Rana R, Sharma R, Kumar A. Repurposing of Existing Statin drugs for treatment of Microbial Infections: How much Promising? Infectious disorders drug targets 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30081793
  13. Bajnok L. [Newer evidences and recommendations in lipidology]. Orvosi hetilap 2018; 159:1303-1309. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078359
  14. Bahrami A, Parsamanesh N, Atkin SL et al. Effect of statins on toll-like receptors: a new insight to pleiotropic effects. Pharmacol Res 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30120976
  15. Streja E, Streja DA, Soohoo M et al. Precision Medicine and Personalized Management of Lipoprotein and Lipid Disorders in Chronic and End-Stage Kidney Disease. Seminars in nephrology 2018; 38:369-382. http://www.ncbi.nlm.nih.gov/pubmed/?term=30082057

Safety and side effects

  1. Balestrino M, Adriano E. Statin-induced myopathy prevented by creatine administration. BMJ case reports 2018; 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30150340
  2. Feng P, Zhao L, Guo F et al. The enhancement of cardiotoxicity that results from inhibiton of CYP 3A4 activity and hERG channel by berberine in combination with statins. Chemico-biological interactions 2018; 293:115-123. http://www.ncbi.nlm.nih.gov/pubmed/?term=30086269
  3. Eljaaly K, Alshehri S, Bhattacharjee S et al. Contraindicated drug-drug interactions associated with oral antimicrobial agents prescribed in the ambulatory care setting in the United States. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30107284
  4. Vassy JL, Chun S, Advani S et al. Impact of SLCO1B1 pharmacogenetic testing on patient and healthcare outcomes: A systematic review. Clinical pharmacology and therapeutics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30137643
  5. Dein E, Manno R, Syed A et al. Ranolazine-induced Elevation of Creatinine Kinase in the Absence of Statin Usage. Cureus 2018; 10:e2832. http://www.ncbi.nlm.nih.gov/pubmed/?term=30131925
  6. Pasnoor M, Barohn RJ, Dimachkie MM. Toxic myopathies. Current opinion in neurology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30080718
  7. Choi Y, Lee S, Jang IJ, Yu KS. Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers. Drug design, development and therapy 2018; 12:2301-2309. http://www.ncbi.nlm.nih.gov/pubmed/?term=30087555
  8. Mast N, Bederman IR, Pikuleva IA. Retinal Cholesterol Content is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol. Drug metabolism and disposition: the biological fate of chemicals 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30115644
  9. Bostanitis I, Tsalidou M. Atorvastatin induced gynecomastia in a dyslipidemic patient. A case report. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30145234
  10. McPheeters CM, Wiedmar JA, Pinkston CM, Weant KA. Implications of Statin Use on Vasopressor Therapy in the Setting of Septic Shock. Hospital pharmacy 2018; 53:152-156. http://www.ncbi.nlm.nih.gov/pubmed/?term=30147135
  11. Riaz R, Merchant AZ, Ul Haq MS et al. Statins everyday versus alternate days: Is there a difference in myalgia rates? Indian Heart J 2018; 70:492-496. http://www.ncbi.nlm.nih.gov/pubmed/?term=30170642
  12. Verdoia M, Nardin M, Negro F et al. Impact of statin therapy on the immature platelet count in patients with coronary artery disease: A single centre cohort study. Int J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30150123
  13. Yagi S, Kondo D, Ise T et al. Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome. J Atheroscler Thromb 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30135329
  14. Leite GAA, Figueiredo TM, Pacheco TL et al. Reproductive outcomes in rat female offspring from male rats co-exposed to rosuvastatin and ascorbic acid during pre-puberty. Journal of toxicology and environmental health. Part A 2018:1-20. http://www.ncbi.nlm.nih.gov/pubmed/?term=30081759
  15. Zhang X, Hong S, Yen R et al. A system to monitor statin-induced myopathy in individual engineered skeletal muscle myobundles. Lab on a chip 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30112530
  16. Wang Y, Jin Y, Yun X et al. Co-administration with simvastatin or lovastatin alters the pharmacokinetic profile of sinomenine in rats through cytochrome P450-mediated pathways. Life sciences 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30096386
  17. Carvalho AAS, Silva VGD, Vieira TF et al. Proposed cut-off for reactivity of anti-HMGCR and anti-SRP antibodies in patients statin-exposed and statin-unexposed. Medicine (Baltimore) 2018; 97:e11858. http://www.ncbi.nlm.nih.gov/pubmed/?term=30170376
  18. Ciric D, Martinovic T, Petricevic S et al. Metformin exacerbates and simvastatin attenuates myelin damage in high fat diet-fed C57BL/6 J mice. Neuropathology : official journal of the Japanese Society of Neuropathology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30123961
  19. Soko ND, Chimusa E, Masimirembwa C, Dandara C. An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C. Pharmacogenomics J 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30100615
  20. Bahrami A, Parsamanesh N, Atkin SL et al. Effect of statins on toll-like receptors: a new insight to pleiotropic effects. Pharmacol Res 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30120976

Stroke and CNS

  1. Ramanan VK, Przybelski SA, Graff-Radford J et al. Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults. Journal of Alzheimer's disease : JAD 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30149450
  2. Texakalidis P, Giannopoulos S, Jonnalagadda AK et al. Preoperative Use of Statins in Carotid Artery Stenting: A Systematic Review and Meta-analysis. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 2018:1526602818794030. http://www.ncbi.nlm.nih.gov/pubmed/?term=30101624
  3. Ziff OJ, Banerjee G, Ambler G, Werring DJ. Statins and the risk of intracerebral haemorrhage inpatients withstroke:systematic review and meta-analysis. Journal of neurology, neurosurgery, and psychiatry 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30150320
  4. Cheng ZJ, Dai TM, Shen YY et al. Atorvastatin Pretreatment Attenuates Ischemic Brain Edema by Suppressing Aquaporin 4. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30093197
  5. Pan ML, Hsu CC, Chen YM et al. Statin Use and the Risk of Dementia in Patients with Stroke: A Nationwide Population-Based Cohort Study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30087076
  6. Howard G, Schwamm LH, Donnelly JP et al. Participation in Get With the Guidelines-Stroke and Its Association With Quality of Care for Stroke. JAMA neurology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30083763
  7. Rozani V, Gurevich T, Giladi N et al. Higher serum cholesterol and decreased Parkinson's disease risk: A statin-free cohort study. Movement disorders : official journal of the Movement Disorder Society 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30145829

Triglycerides/HDL

  1. Nichols GA, Philip S, Reynolds K et al. Comparison of Medical Care Utilization and Costs Among Patients With Statin-Controlled Low-Density Lipoprotein Cholesterol With Versus Without Hypertriglyceridemia. Am J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30086877
  2. Langlois MR, Nordestgaard BG. Which Lipids Should Be Analyzed for Diagnostic Workup and Follow-up of Patients with Hyperlipidemias? Current cardiology reports 2018; 20:88. http://www.ncbi.nlm.nih.gov/pubmed/?term=30120626
  3. Tada H, Kawashiri MA, Nomura A et al. Serum triglycerides predict first cardiovascular events in diabetic patients with hypercholesterolemia and retinopathy. Eur J Prev Cardiol 2018:2047487318796989. http://www.ncbi.nlm.nih.gov/pubmed/?term=30160521

Trials

  1. Donald Harvey R, Aransay NR, Isambert N et al. Effect of multiple-dose osimertinib on the pharmacokinetics of simvastatin and rosuvastatin. Br J Clin Pharmacol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30171779
  2. Nicholls SJ, Lincoff AM, Bash D et al. Assessment of Omega-3 Carboxylic Acids in Statin Treated Patients with High Levels of Triglycerides and Low Levels of High Density Lipoprotein Cholesterol: Rationale and Design of the STRENGTH Trial. Clin Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30125052
  3. Bae JC, Min KW, Kim YH et al. Efficacy and safety of fixed-dose comBination therApy with gemigLiptin (50 mg) and rosuvAstatiN (20 mg) Compared with Each monotherapy in patients with type 2 diabetes and dyslipidaemia (BALANCE): A multicentre, randomized, double-blind, controlled, phase 3 trial. Diabetes Obes Metab 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084112
  4. Tani S, Matsuo R, Hirayama A. Does administration of eicosapentaenoic acid increase soluble thrombomodulin level in statin-treated patients with stable coronary artery disease? Heart Vessels 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30143885
  5. McPheeters CM, Wiedmar JA, Pinkston CM, Weant KA. Implications of Statin Use on Vasopressor Therapy in the Setting of Septic Shock. Hospital pharmacy 2018; 53:152-156. http://www.ncbi.nlm.nih.gov/pubmed/?term=30147135
  6. Verdoia M, Nardin M, Negro F et al. Impact of statin therapy on the immature platelet count in patients with coronary artery disease: A single centre cohort study. Int J Cardiol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30150123
  7. Probstfield JL, Boden WE, Anderson T et al. Cardiovascular outcomes during extended follow-up of the AIM-HIGH trial cohort. J Clin Lipidol 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30131256
  8. Krysiak R, Szkrobka W, Okopien B. Different Effects of Atorvastatin on Cardiometabolic Risk Factors in Young Women With and Without Hyperprolactinemia. Journal of clinical pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30129670
  9. Alghofaily M, Tordik P, Romberg E et al. Healing of Apical Periodontitis after Nonsurgical Root Canal Treatment: The Role of Statin Intake. Journal of endodontics 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078575
  10. Kulik A, Abreu AM, Boronat V, Ruel M. Intensive versus moderate statin therapy and early graft occlusion after coronary bypass surgery: The Aggressive Cholesterol Therapy to Inhibit Vein Graft Events randomized clinical trial. The Journal of thoracic and cardiovascular surgery 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30122341
  11. Gupta A, Mackay J, Whitehouse A et al. Long-term mortality after blood pressure-lowering and lipid-lowering treatment in patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Legacy study: 16-year follow-up results of a randomised factorial trial. Lancet 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30158072
  12. Calfee CS, Delucchi KL, Sinha P et al. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. The lancet. Respiratory medicine 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30078618
  13. Baptista LC, Verissimo MT, Martins RA. Statin combined with exercise training is more effective to improve functional status in dyslipidemic older adults. Scandinavian journal of medicine & science in sports 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30137683

Women and elderly

  1. Putra RA, Effendi JS, Permadi W et al. Role of statin as inducer of Hmox-1 system in treatment of preeclampsia. Cell Mol Biol (Noisy-le-grand) 2018; 64:1-4. http://www.ncbi.nlm.nih.gov/pubmed/?term=30084810
  2. Krysiak R, Szkrobka W, Okopien B. Different Effects of Atorvastatin on Cardiometabolic Risk Factors in Young Women With and Without Hyperprolactinemia. Journal of clinical pharmacology 2018. http://www.ncbi.nlm.nih.gov/pubmed/?term=30129670
  3. Leite GAA, Figueiredo TM, Pacheco TL et al. Reproductive outcomes in rat female offspring from male rats co-exposed to rosuvastatin and ascorbic acid during pre-puberty. Journal of toxicology and environmental health. Part A 2018:1-20. http://www.ncbi.nlm.nih.gov/pubmed/?term=30081759
 
 
 
 
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